1. Crate Gxt 212 Amp
2. Crate Gxt 212 Manual Dexterity 2
3. Crate Gx 212 Manual Dexterity Activities
4. Crate Amps
5. Crate Gxt 212 Manual Dexterity Test

• Work Station - Get the lowest price on Work Station, online at AllegroMedical.com.
• Jul 28, 2011  Let's talk Crate solid state NO. Anna_Laurel, Jan 23, 2010. Anna_Laurel, Jan 23, 2010 #2. Art_z, Seanrg and fretless like this. Jan 23, 2010 #3. Rockon1 Member. Messages: 11,823. I just repaired a '95 Crate GX-212+ last night. All four input jack pins had come loose from the (flimsy) PCB. This time I simply resoldered them (removed old.

Jun 08, 2013  I hoping someone may have more info on this used Crate amp I bought this week --- it is a Crate GXT 100 Dual Triode with a single 12' Celestion speaker. What I am really looking for is an downloadable owners manual or specs. It is very easy, but requires a slight amount of manual dexterity and good lighting to put on the two thumb wheel nuts. Smaller hands help. It can be set up in less than 30 minutes. That is one very large crate delivered to your home but only inside the front door or garage or whatever,) and that's it. As to the chair itself: I've only just. Crate GXT-100 combo guitar amplifier, Crate GXT-100, Crate GXT 100, Crate GXT100, GXT-100, GXT 100, GXT100 Product reviews Crate GXT-100 combo guitar amplifier Write a review.

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Publication number

CN102573631A

CN102573631ACN2010800429642ACN201080042964ACN102573631ACN 102573631 ACN102573631 ACN 102573631ACN 2010800429642 ACN2010800429642 ACN 2010800429642ACN 201080042964 ACN201080042964 ACN 201080042964ACN 102573631 ACN102573631 ACN 102573631A

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CN

China

Prior art keywords

test

frame

Chinese (zh)

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S.N.勒

霍夫曼-拉罗奇有限公司

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Critical

Application filed by 霍夫曼-拉罗奇有限公司filedPriority to PCT/EP2010/005688prioritypatent/WO2011035867A2/en

Criticalpatent/CN102573631A/en

Critical

Criticalpatent/CN102573631B/en

Links

• Abstract239000010839body fluidSubstances0Title3
• Abstract4
• Abstract1

Classifications

• A—HUMAN NECESSITIES
• A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
• A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
• A61B5/1411—Devices for taking blood samples by percutaneous method, e.g. by lancet
• A—HUMAN NECESSITIES
• A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
• A61B5/15—Devices for taking samples of blood
• A61B5/150015—Source of blood
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/150007—Details
• A61B5/150061—Means for enhancing collection
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/150007—Details
• A61B5/150183—Depth adjustment mechanism using end caps mounted at the distal end of the sampling device, i.e. the end-caps are adjustably positioned relative to the piercing device housing for example by rotating or screwing
• A—HUMAN NECESSITIES
• A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
• A61B5/15—Devices for taking samples of blood
• A61B5/150175—Adjustment of penetration depth
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/150007—Details
• A61B5/150274—Manufacture or production processes or steps for blood sampling devices
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/150007—Details
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/150007—Details
• A61B5/150381—Design of piercing elements
• A61B5/150419—Pointed piercing elements, e.g. needles, lancets for piercing the skin comprising means for capillary action
• A—HUMAN NECESSITIES
• A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
• A61B5/15—Devices for taking samples of blood
• A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
• A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/150007—Details
• A61B5/150381—Design of piercing elements
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/150007—Details
• A61B5/150381—Design of piercing elements
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/150007—Details
• A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/150007—Details
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
• A61B5/15103—Piercing procedure
• A61B5/15109—Fully automatically triggered, i.e. the triggering does not require a deliberate action by the user, e.g. by contact with the patient's skin
• A—HUMAN NECESSITIES
• A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
• A61B5/15—Devices for taking samples of blood
• A61B5/15101—Details
• A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
• A—HUMAN NECESSITIES
• A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
• A61B5/15—Devices for taking samples of blood
• A61B5/15101—Details
• A61B5/15128—Means for controlling the lancing movement, e.g. 2D- or 3D-shaped elements, tooth-shaped elements or sliding guides comprising 2D- or 3D-shaped elements, e.g. cams, curved guide rails or threads
• A—HUMAN NECESSITIES
• A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
• A61B5/15—Devices for taking samples of blood
• A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
• A—HUMAN NECESSITIES
• A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
• A61B5/15—Devices for taking samples of blood
• A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
• A61B5/15149—Arrangement of piercing elements relative to each other
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
• A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
• A61B5/15159—Piercing elements stocked in or on a disc
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
• A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
• A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
• A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
• A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
• A—HUMAN NECESSITIES
• A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
• A61B5/15—Devices for taking samples of blood
• A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
• A61B5/150083—Means for enhancing collection by vibration, e.g. ultrasound
• Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
• Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
• Y10T29/49—Method of mechanical manufacture
此外，还存在对也有效地将小的体液试样从刀传输到测试条以消除对体液的任何浪费的多功能一次性单元的需要。 Further, there is a need for multiple disposable unit also efficiently transfer the body fluid sample from a small knife to the test strip to eliminate any waste of body fluids.[0007] 用于集成的一次性盒中的刀的精确切缝型式保证了在对皮肤或者组织进行切缝期间收集合适量的体液试样。 [0007] The precise slit pattern for the integrated disposable blade cartridge to ensure the appropriate amount of body fluid sample collected during the skin or tissue lancing.用于刀的精确切缝型式也保证了在对皮肤或者组织切缝期间切割合适数量的毛细血管。 Precise slit pattern for the knife also ensures the capillaries to the skin during lancing or cutting tissue suitable number.例如，如果切割太少的毛细血管，那么体液试样可能不是足够的大量以产生准确的测试结果。 For example, if too little cutting capillaries, the body fluid sample may not be large enough to generate accurate test results.如果切割太多的毛细血管，那么收集了过大量的体液试样，且用户可能经历比获得合适体液试样所必需经历的疼痛更大程度的疼痛。 If too much cutting capillaries, then a large number of collected body fluid sample, and the user may experience greater pain than necessary to obtain a suitable sample of body fluid subjected to pain.已经使用了刀和刀进入方式的各种构造来尝试解决这些问题。 Various configurations have been used knives and knife into the way to try to solve these problems.一个构造是具有直的进入方式的大体直的刀。 A substantially straight blade is configured with a straight entry mode.关于具有直的进入方式的直的刀的一个问题在于：刀的深的穿刺深度，这导致了许多毛细血管被切割，并且导致了用户的极大程度的疼痛。 One problem with a straight knife straight into the way of that: deep penetration depth of the knife, which has led to many capillaries are cut, and leads to a great degree of user pain.另一构造是具有旋转进入方式的弯曲刀， 这也可能导致过大的伤口和流体试样，以及导致对用户而言不必要的疼痛。 Another configuration is a curved blade having a rotational entry mode, which may also result in excessive and wound fluid sample, and cause unnecessary pain for the user.

[0008] 因而，在该领域中存在对改进的需要。 [0008] Accordingly, a need exists for improvements in the art.

发明内容 SUMMARY

[0009] 一方面涉及一种通过将部件嵌入或者放置入框架中来组装的集成盒。 [0009] In one aspect relates to a member or by embedding the assembled frame placed into the integration cassette.该集成盒包括：测试环，所述测试环具有化学物的连续条，使得当该测试环被定位在所述框架中时，该测试环能够分段成多个测试段。 The integrated cartridge comprising: a test loop, the loop having a continuous strip test chemicals, such that when the test loop is positioned in the frame, the test ring can be segmented into a plurality of test sections.该集成盒也包括：刀轮，所述刀轮的刀缘具有从所述刀缘径向向内延伸的多个刀。 The integrated cartridge also comprises: cutter wheel, the knife edge of the cutter wheel having a plurality of knife blade extending radially from the rim inwardly.所述刀中的每一个具有腿部、接触所述测试段和将体液试样沉积到所述测试段上的接触部、和大体上横过所述腿部延伸的刀尖。 Each of the blade having a leg portion contacting the test section and the body fluid sample is deposited into the contact portion on the cutting edge of the test section, and extending substantially across the leg.所述集成盒包括框架，所述框架具有装蛋箱(或分格箱）形状，其具有多个室，以方便将刀轮和测试环的组件嵌入到所述框架上和将所述测试环分段成多个测试段，使得在所述框架中所述刀中的每一个定位成紧接一个测试段。 The integrated cartridge including a frame, said frame having an egg crate (or bins box) shape, having a plurality of chambers to facilitate embedding the knife wheel and components of the test to the test frame and said ring segmented into a plurality of test sections, such that in each of the frame located immediately after a test section of said blade.

[0010] 另一方面涉及一种组装集成的一次性盒的方法。 [0010] Another aspect relates to a method of assembling an integrated disposable cassette method.所述方法包括：通过将刀轮嵌入到框架上来组装集成的一次性盒。 The method comprising: embedding cutter wheel to the frame assembly up integrated disposable cartridge.所述刀轮的边缘具有多个径向向内延伸的刀，且所述框架具有限定了多个室的多个轮辐。 Said knife edge blade wheel having a plurality of radially inwardly extending, and the frame having a plurality of spokes defining a plurality of chambers.刀中的每一个都被定位在所述室的一个内。 Each blade are positioned on one of said inner chamber.

[0011] 另一方面涉及一种使用刀自动收集体液试样和将体液试样传输到测试条的方法。 [0011] Another aspect relates to a method of using a knife, and the automatic collection of body fluid sample body fluid sample to the test strip.一种集成的一次性盒包括：框架；刀轮，所述刀轮具有从边缘径向向内延伸的多个刀；以及测试环，所述测试环具有多个测试段，其中所述多个刀接触所述多个测试段。 An integrated disposable cartridge comprising: a frame; cutter wheel, said wheel having a plurality of cutter blade extending radially inwardly from an edge; and a test ring, said ring having a plurality of test test sections, wherein said plurality of contacting said plurality of test blade segments.接着，通过旋转所述刀中的一个离开所述多个测试段，从而利用该刀在组织中形成切口。 Next, out of the plurality of test sections of the blade by rotating one, so that the blade is formed using an incision in the tissue.体液试样利用所述刀上的毛细槽收集，并且该刀通过将其朝向所述多个测试段旋转来从组织中的切口退出。 Capillary groove on the collected body fluid sample with the blade, and the tool by which the plurality of test sections toward the rotary to exit from the incision in tissue.通过使该刀接触测试段来释放所述体液试样，从而将该刀上的毛细槽中的体液试样传输到所述测试段中的一个。 By making the blade section releases the contact with the test body fluid sample, such that the transmission of body fluid sample on the capillary grooves to a knife in the test section.

[0012] 再一方面涉及微取样器轮。 [0012] Still another aspect relates microsampler wheel.微取样器轮包括：基部、多个刀、和多个肋。 Microsampler wheel comprising: a base, a plurality of knives, and a plurality of ribs.所述多个肋和所述多个刀从所述基部径向向外延伸，并且所述多个肋和所述多个刀彼此交替。 The plurality of ribs and a plurality of said blade extending radially outwardly from said base portion, and the plurality of ribs alternate with each other and said plurality of knives.每个刀包括被构造成在皮肤中形成切口的弯曲刀尖。 Each cutter includes configured to form an incision in skin bent tip.所述刀中的每个也被构造成绕所述基部旋转，使得刀的旋转曲率与刀尖的曲率相似。 Each of the blade is also configured to rotate about the curvature of the rotating base, so that the rotation of blade tip curvature is similar.所述多个肋中的每个都定位成用于确定刀尖的穿刺深度的参考平面。 Each of the plurality of ribs are positioned in the reference plane for determining the penetration depth of the tool tip.

[0013] 另外的形式、目的、特征、方面、益处、优点和实施例将从本文所提供的详细说明和附图而变得显而易见。 [0013] Further forms, objects, features, aspects, benefits, advantages, embodiments and the accompanying drawings and from the detailed description provided herein, will become apparent from the embodiments.

附图说明[0014] 图1是集成的一次性盒的分解立体图； 图2是图1的盒的俯视立体图； 图3是结合到图1的盒中的刀轮的仰视立体图； 图4是图3的刀轮的俯视图； 图5是图3的刀轮的侧视图； 图6是图1的盒的放大的剖视图； 图7是图1的盒中所使用的框架的立体图； 图8是装载到刀驱动器机构中的图1的盒的仰视立体图； 图9是图8的机构的剖视图； 图10是结合了切缝帽的图8的机构的俯视立体图； 图11是从集成的一次性盒的顶部观察的该集成的一次性盒的分解立体图； 图12是从集成的一次性盒的底部观察的图11的该集成的一次性盒的分解立体图； 图13是结合到图11的盒中的刀轮和测试环的俯视立体图； 图14是结合到图11的盒中的刀轮和测试环的俯视立体图； 图15是结合到图11的盒中的刀轮、盖阻挡件和驱动器的俯视立体图； 图16是结合到图11的盒中的刀轮、盖阻挡件 BRIEF DESCRIPTION [0014] FIG. 1 is an exploded perspective view of an integrated disposable cassette; FIG. 2 is a top perspective view of the cartridge of FIG. 1; FIG. 3 is incorporated into a bottom perspective view of the cutter wheel cartridge of FIG. 1; FIG. 4 is a diagram a plan view of the cutter wheel. 3; FIG. 5 is a side view of a cutter wheel of FIG. 3; FIG. 6 is an enlarged sectional view of the cartridge of FIG. 1; FIG. 7 is a perspective view of the frame of the cartridge of FIG. 1 is used; FIG. 8 is loaded a bottom perspective view of the box cutter drive mechanism of FIG. 1; FIG. 9 is a cross-sectional view of the mechanism of FIG. 8; FIG. 10 is a combination of a top perspective view of the mechanism of the lancing cap of FIG. 8; FIG. 11 is an integrated disposable cartridge an exploded perspective view of the integrated disposable cassette is viewed from the top; FIG. 12 is an exploded perspective view viewed from the bottom of the integrated disposable cassette of the integrated disposable cassette of FIG. 11; FIG. 13 is bonded to the cartridge 11 in FIG. the cutter wheel and testing a top ring perspective view; FIG. 14 is a top perspective view of a cassette incorporated into FIG. 11 cutter wheel and test ring; FIG. 15 is coupled to the cutter wheel cartridge of FIG. 11, the cover block member and the drive top perspective view; FIG. 16 is coupled to the cutter wheel cartridge of FIG. 11, the cover block member和驱动器的俯视立体图； 图17是图16的刀轮、盖阻挡件和驱动器的侧视图； 图18是处于闭合位置中的盖阻挡件的俯视图； 图19是处于打开位置中的图18的盖阻挡件的俯视图； 图20是根据另一实施例的微取样器轮的俯视立体图； 图21是图20的微取样器轮的剖视图； 图22是包括测试元件的图20的微取样器轮的剖视图； 图23是图22的刀和毛细管的局部正视图； And a top perspective view of a driver; FIG. 17 is a diagram showing the cutter wheel 16, a side view of the lid stopper member and the driver; FIG. 18 is a top view of the closed position of the lid stopper member; FIG. 19 is a cover in an open position in FIG. 18 top view showing the blocking; FIG. 20 is a top perspective view of the micro sampler wheel according to another embodiment; Figure 21 is a cross-sectional view microsampler wheel of FIG. 20; FIG. 22 is a micro sampler wheel comprises a test element of FIG. 20 cross-sectional view; FIG. 23 and FIG. 22 is a blade partial front view of the capillary;

图M是根据另一实施例的、包括靠近刀尖定位的测试元件的微取样器轮的剖视图； 图25是图M的刀和毛细管的局部正视图； FIG M according to another embodiment, including a cross-sectional view of the test microsampler wheel positioned near the tip element; FIG. 25 is a view of the knife and the M partial front view of the capillary;

图26是根据另一实施例的、包括靠近刀尖定位的测试元件的微取样器轮的剖视图； 图27是图沈的刀和毛细管的局部正视图； 图观是根据另一实施例的、微取样器轮的俯视立体图； 图四是图观的微取样器轮的俯视立体图； 图30是图观的微取样器轮的俯视立体图； 图31是图观的微取样器轮的俯视立体图； 图32是图观的微取样器轮的俯视立体图； FIG 26 is another embodiment of the embodiment, including a cross-sectional view of the test microsampler wheel positioned near the tip element; FIG. 27 is a diagram sink blade and capillaries partial front view; FIG concept according to another embodiment, a top perspective view of the micro sampler wheel; Figure IV is a top perspective view of View microsampler wheel; FIG. 30 is a top perspective view of View microsampler wheel; FIG. 31 is a top perspective view of View microsampler wheel; FIG 32 is a top perspective view of FIG microsampler wheel concept;

图33是从集成的一次性盒的顶部观察的该集成的一次性盒的分解立体图； 图34是结合到图33的盒中的测试环和测试环框架的仰视立体图； 图35是图33的集成的一次性盒的俯视立体图； 图36是图33的集成的一次性盒的仰视立体图； 图37是结合到图33的集成的一次性盒的剖视图中的驱动器的立体图； 图38是图37的机构的侧视图； FIG 33 is an exploded perspective view of the disposable cassette of the integrated viewed from the integrated top of the disposable cartridge; FIG. 34 is incorporated into a bottom perspective view of the cartridge of FIG. 33 in the test loop and the test ring frame; FIG. 35 is a diagram 33 a top perspective view of an integrated disposable cassette; FIG. 36 is integrated in a bottom perspective view of FIG. 33 of the disposable cartridge; FIG. 37 is coupled to the perspective view of a cross-sectional view of the disposable cartridge integrated in FIG. 33 in the driver; FIG. 38 is a diagram 37 a side view of the mechanism;

图39是驱动器处于部分致动位置中的图37的机构的立体图；图40是驱动器处于完全致动位置中的图37的机构的立体图； 图41是根据另一实施例的刀框架、刀轮和测试环的俯视立体图； 图42是描绘了处于初始位置中的刀的图41的机构的立体图； 图43是描绘了处于完全致动位置中的刀的图42的机构的立体图； 图44是描绘了处于最终位置中的刀的图42的机构的立体图； 图45是根据另一实施例的刀框架、刀轮和测试环的立体图，其描绘了处于初始位置中的刀； FIG 39 is a perspective view of a mechanism part actuated position of FIG. 37 drives are; FIG. 40 is a drive is a perspective view of the mechanism fully actuated position of FIG. 37; FIG. 41 is a cutter frame to another embodiment, the cutter wheel and a top perspective view of a test ring; FIG. 42 is a graph depicting a perspective view of the mechanism in the initial position of the knife of FIG. 41; FIG. 43 is a graph depicting a perspective view of the mechanism in a fully actuated position of the knife in FIG. 42; FIG. 44 is It depicts a perspective view of the mechanism in the final position of the knife of FIG. 42; FIG. 45 is a cutter frame to another embodiment, a perspective view of the cutter wheel and ring test, depicting the knife in an initial position;

图46是描绘了处于完全致动位置中的刀的图45的机构的立体图； 图47是描绘了处于最终位置中的刀的图45的机构的立体图； 图48、49、50、51、52和53是关于致动刀和将体液试样传输到测试段的各种技术的示意性图示； FIG 46 is a graph depicting a perspective view of the mechanism in a fully actuated position of the knife of FIG. 45; FIG. 47 is a perspective view depicting the mechanism in the final position of the knife of FIG. 45; FIG 48,49,50,51,52 and it is about 53 and the activated tool body fluid sample to schematically illustrate the various techniques of the test section;

图M是根据一个实施例的便携式计量器系统的立体图； FIG M is a perspective view of a portable meter system of the embodiment;

图55是在罩打开的情况下的图M的机构中被装载的刀框架、刀轮和测试环的俯视 FIG 55 is a blade mechanism of FIG frame M in a case of opening the cover is loaded, a top view of the cutter wheel and ring test

图； Figure;

图56是顶盖被移除的情况下的图M的机构的俯视立体图； 图57是顶盖和底盖被移除的情况下的图56的机构的仰视立体图； 图58是在下印刷电路板被移除的情况下的图57的机构的仰视立体图； 图59是在上印刷电路板被移除的的情况下的图58的机构的局部俯视立体图； 图60是图59的机构的局部俯视立体图； FIG 56 is a top perspective view of the mechanism M in the case of FIG cover removed; FIG. 57 is a bottom perspective view of the mechanism of FIG. 56 in the case where the top and bottom covers removed; FIG. 58 is a printed circuit board in the next a bottom perspective view of the mechanism of FIG. 57 in the case removed; local means of FIG. 59 is a diagram in a case where the printed circuit board is removed to 58 a top perspective view; FIG. 60 is a partial mechanism of FIG. 59 is a top view FIG perspective;

图61是在释放臂被移除的情况下的图60的机构的局部俯视立体图； 图62是图61的机构的局部俯视图； 图63是图62的机构的局部分解仰视图； 图64是上印刷电路板、下印刷电路板和电池的仰视立体图； 图65是显示器、上印刷电路板、下印刷电路板和电池的俯视立体图； 图66是在框架和刀框架被移除的情况下的图61的机构的俯视立体图； 图67是图59的机构的部分俯视立体图； 图68是图59的机构的部分俯视立体图； 图69是图59的机构的部分俯视立体图； FIG 61 is a partial mechanism of FIG case where the release arm is removed 60 top perspective view; FIG. 62 is a partial top plan view of the mechanism of FIG. 61; FIG. 63 is a partially exploded bottom view of the mechanism of FIG. 62; FIG. 64 is a a bottom perspective view of a printed circuit board, the printed circuit board and the battery; FIG. 65 is a display, a top perspective view of the printed circuit board, the printed circuit board and the battery; FIG. 66 is a diagram in the case where the frame and the tool frame removed of a top perspective view of the mechanism 61; FIG. 67 is a partial top view of the mechanism of Figure 59 a perspective view; FIG. 68 is a partial top view of the mechanism of Figure 59 a perspective view; FIG. 69 is a partial top view of the mechanism of Figure 59 a perspective view;

图70是曲柄轴、曲柄、翻转连杆、阻尼器、弹簧电机、第四齿轮和启动齿轮的立体图； 图71是根据一个实施例的便携式计量器系统的立体图； FIG 70 is a crankshaft, crank, connecting rod flip damper, a spring motor, a fourth gear perspective view and a starting gear; FIG. 71 is a perspective view of a portable meter system according to one embodiment;

图72是在初始位置中顶盖和底盖被移除的情况下的图71的机构的局部俯视立体图； 图73是在浅穿刺深度设置的初始位置中、顶盖和底盖被移除的情况下的图71的机构的局部俯视立体图； FIG 72 is a partial mechanism of FIG. 71 in the case where the top and bottom covers are removed in an initial position, a top perspective view; FIG. 73 is a shallow penetration depth in the initial position settings, the top and bottom covers removed FIG 71 is a partial mechanism of the case where a top perspective view;

图74是在浅穿刺深度设置的完全延伸位置中、顶盖和底盖被移除的情况下的图71的机构局部俯视立体图； FIG 74 is a fully extended position shallower penetration depth setting, the mechanism of FIG. 71 in the case where the top and bottom covers removed partial top perspective view;

图75是在浅穿刺深度设置的最终位置中、顶盖和底盖被移除的情况下的图71的机构的局部俯视立体图； FIG 75 is a shallow penetration depth in the end position setting, the local mechanism in the case of FIG. 71 top and bottom covers removed top perspective view;

图76是在深穿刺深度设置的初始位置中、顶盖和底盖被移除的情况下的图71的机构的局部俯视立体图；图77是在深穿刺深度设置的完全延伸位置中、顶盖和底盖被移除的情况下的图71的机构的局部俯视立体图； FIG 76 is a deep penetration depth setting an initial position, a local mechanism in the case of FIG. 71 top and bottom covers removed top perspective view; FIG. 77 is in the fully extended position disposed deep penetration depth, the top cover FIG mechanism 71 and partially in the case of a top cover removed perspective view;

图78是在深穿刺深度设置的最终位置中、顶盖和底盖被移除的情况下的图71的机构的局部俯视立体图； The final position of FIG. 78 is disposed in a deep penetration depth, the local mechanism in the case of FIG. 71 top and bottom covers removed top perspective view;

图79是图76的机构的局部俯视立体图； 图80是具有底盖的图73的机构的局部俯视立体图； 图81是具有底盖的图76的机构的局部俯视立体图； 图82是触发器系统的立体图； 图83是图82的机构的立体图； 图84是图82的机构的立体图； 图85是图82的机构的立体图。 FIG 79 is a partial mechanism of FIG. 76 is a top perspective view; FIG. 80 is a partially with FIG bottom cover mechanism 73 is a top perspective view; FIG. 81 is a partially mechanism having a bottom cover of FIG. 76 is a top perspective view; FIG. 82 is a trigger system perspective view; FIG. 83 is a perspective view of the mechanism of FIG. 82; FIG. 84 is a perspective view of the mechanism of FIG. 82; FIG. 85 is a perspective view of the mechanism 82 of FIG.

具体实施方式 Detailed ways

[0015] 为了促进对本发明原理的理解，现在将参照附图中所示的实施例，并且将用具体的语言来对这些实施例进行描述。 [0015] To promote an understanding of the principles of the present invention is now illustrated in the embodiment with reference to the drawings, and specific language will be used to describe these embodiments.但是，必须理解，并不旨在由此限制本发明的保护范围。 However, it must be understood that is not intended to thereby limit the scope of the present invention.与本发明相关的领域中的普通技术人员通常能想到所描述的实施例中的任何替代和进一步的修改以及对如此处所描述的本发明的原理的任何进一步的应用。 Field relevant to the present invention, one of ordinary skill would normally occur to any further applications of any alterations and further modifications in the embodiments and principles of the invention as described herein for the embodiment described.本发明的一个实施例将被详细地显示，但是对相关领域中普通技术人员而言显而易见的是：与本发明不相关的一些特征可以为了简洁的目的而不进行显示。 One embodiment of the present invention will be shown in detail, but to those of ordinary skill in the relevant art are apparent: some features are not relevant to the present invention can not be displayed for purposes of brevity.

[0016] 关于附图在具体描述中的任何方向性参照(例如，上或者下，或者顶部或底部)，都只是为了描述的方便，其本身不会将本发明或者本发明的任何部件限制到任何特定的位置或者空间取向。 [0016] For any directional references (e.g., upper or lower, or top or bottom) in the detailed description of the drawings, are merely for convenience of description, the present invention does not itself, or any member of the present invention is limited to any particular position or spatial orientation.

[0017] 一个实施例涉及一种独特的集成的一次性盒或盘，以及涉及用于便宜地制造该盒或者盘的技术，该技术依靠该盒或盘的设计。 [0017] One embodiment relates to a unique integrated disposable cassette or disc, and relates to the design of the cassette or disc inexpensively manufacturing technique, the technique relies on the cassette or disc.该独特的盒利用独特的“嵌入（drop-in)”或者“模块化”设计，该“嵌入”或者“模块化”设计允许刀轮上的多个刀在盘形框架的试样室中对齐。 This unique cartridge using a unique 'embedded (drop-in)' or 'modular' design, the 'embedding' or 'modular' design allows a plurality of knives on a cutter wheel is aligned in the sample chamber of a disc-shaped frame .该独特的嵌入设计消除了对多个刀进行单独的对齐和放置的需要。 This unique design eliminates the need for embedding a plurality of individual knife alignment and placement.测试环也定位在框架上，使得试样室在测试环上形成多个测试元件。 Test rings are also positioned on the frame, the sample chamber is formed such that a plurality of test elements on the test ring.必须理解，刀轮、框架和测试环均单独制造，然后进行组装以形成集成的一次性盒。 It must be understood, the cutter wheel, the frame and test ring are manufactured separately and then assembled to form an integrated disposable cartridge.在一种形式中，刀轮、框架和测试环在所述盒的组装之后被灭菌。 In one form, the lancet wheel, and the test ring frame are sterilized after assembly of the cartridge.在另一形式中，刀轮、框架和测试环被单独灭菌。 In another form, the cutter wheel frame and the test loops are sterilized separately.在对皮肤或者组织进行切缝之前，定位在所述盒的外部上的一个或多个密封箔或片维持所述刀的无菌和所述测试元件的湿度。 Before the skin or tissue lancing locating one or more sealing foils or sheets on the exterior of the cartridge to maintain sterility and humidity of the test element of the knife.所述盒保护其他人以免在对皮肤或者其他组织切缝之后不经意地接触使用过的刀。 The protective cartridge to prevent others in the skin or other tissue after lancing inadvertent contact with the used blade.所述盒包括单独的、分开的室，以在对皮肤或者组织进行切缝之前保持每个测试元件上的化学物的湿度。 The cartridge comprises a single, separate chambers to keep the humidity of chemical on each of the test element before the skin or tissue lancing.刀（或刺血针)的独特形状和框架上的测试元件的放置使得体液试样在紧随已经发生切缝和采样循环之后能够从刀的毛细管自动地传输到测试元件。 The test element is placed on the frame and the unique shape of the knife (or lancet) such that the body fluid sample can be transmitted immediately after the lancing and sampling cycles have occurred from the capillary knife automatically to the test element.体液试样的自动传输使得能够进行关于体液试样的切缝、采样和测试的“一步式”操作。 Automatic transmission enables the body fluid sample 'step' operation with respect to the slit of the body fluid sample, and the test sample.此外，刀构造成收集小量的体液，例如小于0. 1微升，并且将该小量的体液传输到测试段，用于在没有对体液的相当程度的损失的情况下进行分析。 In addition, the knife configured to collect a small amount of body fluid, for example less than 0.1 microliters, and the transmission of a small amount of bodily fluid to the test section, for analysis without loss of body fluids considerable case.必须理解，该一步式操作和小尺寸的盒以及相关联的计量器为用户提供了随时随地（on-the-go)的方便。 It must be understood that a one-step and a small size cassette and associated meter provides users with convenience wherever (on-the-go) a.

[0018] 第二实施例也涉及独特的集成的一次性盒或者盘，以及涉及用于便宜地制造所述盒或者盘的技术。 [0018] The second embodiment also relates to a unique integrated disposable cassette or disc, and to a cartridge for inexpensively manufacturing the disc, or technical.该实施例中的所述盒利用了独特的刀轮设计，其包括与多个肋交替的多个微针或者刀。 The cartridge in this embodiment utilizes the unique design of the cutter wheel, which comprises a plurality of ribs alternating with a plurality of micro needle or blade.该盒包括测试元件盘，所述测试元件盘具有与多个刀相邻定位的多个测试元件。 The disc cartridge includes a test element, the test element disc having a plurality of test elements positioned adjacent a plurality of blade.刀轮和测试元件盘分开制造，然后组装在一起以形成所述盒。 Cutter wheel disc and the test element are manufactured separately and then assembled together to form said cassette.刀轮和测试元件盘一起限定了多个单独的切缝和测试事件。 The test element and lancet wheel disc defining a plurality of separate lancing and testing incident.刀具有独特的内嵌弹簧形状，并且刀尖在切缝期间形成了稍微呈圆形的路径。 The tool has a unique built-spring shape, and the tip is formed somewhat circular path during lancing.刀的独特形状提供了下述状况，即：在对皮肤或者组织进行切缝之后，刀弹回或者返回到其原始的切割前位置。 The unique shape of the knife provided the following conditions, namely: the skin or tissue after lancing blade spring back or return to its original position before cutting.此外，多个刀中的每一个都包括弯曲的刀尖，其对应于在刀的切缝循环期间在挠曲和缩回的过程中由刀尖轨迹形成的圆形路径的曲率。 Further, each of the plurality of knives includes a curved tip, which corresponds to the curvature of the circular path of the knife during a cycle of the slit formed by the cutting edge in the trajectory deflection and retraction process.与弯曲的轨迹路径匹配的刀的弯曲形状模拟了在大部分常用的切缝系统中典型的直线运动。 The curved shape of the curved blade matching simulated trajectory path typical in most conventional lancing linear motion system.对刀尖施力以在穿刺和缩回期间沿循曲线路径的驱动机构顺应刀臂的半径长度的自然弯曲或挠曲，从而增强了对该一次性盒的设计和制造的简化。 Urging tip to conform to the natural radius of bending or flexing in the length of the knife arm and the drive mechanism to follow a piercing curved path during retraction, thereby enhancing simplifying the design and manufacture of disposable cartridges.必须理解，被污染的刀返回到切割前或者未挠曲位置，从而保护其他人以防止其自身被使用的刀意外污染。 It must be understood to be contaminated before cutting or knife to return to the undeflected position, so as to protect other people against accidental contamination which is itself a knife used.每个刀尖都包括尺寸设定成能通过毛细作用收集体液试样的微毛细管。 Each tip comprises a capillary micro-sized to by capillary action to collect a body fluid sample.毛细管定位在刀尖的前面或者后面上，并且毛细管可以从刀尖沿着刀延伸不同的长度。 Capillary positioned on the front or back of the nose, and capillaries may extend along a different length from the blade tip.多个测试元件与刀上的毛细管相邻定位，使得随着刀尖返回到其切割前位置，毛细管中的体液试样从毛细管传输到测试元件。 A plurality of test elements with a capillary tube positioned adjacent the knife, such as a cutting tip returns to its forward position, the body fluid sample in the capillary is transferred from the capillary to the test element.

[0019] 根据一个实施例的盒20显示在图1、图2中。 [0019] According to a cartridge 20 of the embodiment shown in FIG. 1 and FIG 2.盒20构造成对皮肤进行切缝以形成切口，从该切口收集体液试样、分析体液试样、以及被调配（indexed)用于后续的切缝。 Cartridge 20 configured to lancing skin to form an incision, the incision to collect body fluid sample from the analysis of body fluid sample, and a formulation (an indexed) for a subsequent slit.盒20对多个刀和多个测试元件形成无菌环境，并且盒20在对皮肤或者组织切缝之前对多个测试元件的每一个都独立地保持化学物的低湿度。 Cartridge 20 is formed of a plurality of knives sterile environment and a plurality of test elements, and the cartridge 20 before lancing the skin or tissue on each of the plurality of test elements are individually held low humidity chemicals.盒20的单独元件或者模块部件被单独制造，然后组装成最终的形式。 Separate elements or modules member cartridge 20 is manufactured separately and then assembled into the final form.例如，在一个实施例中，盒20包括25个或者更多的切缝和测试模块，通过组装成5或者6个部件来形成盒20。 For example, in one embodiment, the cartridge 25 or 20 including more lancing and testing modules, formed by assembling into a 5 or 6 member cartridge 20.此外，不需要用户输入来将体液试样从刀传输到测试条，因为盒20在皮肤中形成切口之后自动地执行此任务。 In addition, no user input is transmitted to the body fluid sample to the test strip from the lancet, because this task is performed automatically after the cartridge notch 20 is formed in the skin.在切缝和测试之后，盒20还存储被使用的刀和测试元件，以防止计量器污染和/或者包含在盒20中的单独刀和测试元件之间的交叉污染。 After lancing and testing, and the blade cartridge 20 also stores the test elements are used to prevent cross-contamination between the knife and the test element the individual meter contamination and / or contained in the cartridge 20.如图所示，盒20是能够通过盒20的旋转来进行调配的盘形或者圆形，从而在盒20被存储在计量器中时最小化其尺寸。 As illustrated, the cartridge 20 is able to perform a circular disc-shaped or formulated by the rotation of the cartridge 20 so that when the cartridge 20 is stored in the meter to minimize its size.必须理解，盒20可以在其他实施例中具有不同的整体形状。 It must be understood, the cartridge 20 may have a different overall shape in other embodiments.例如，盒20可以是椭圆形、方形、或者矩形，此处只是提及一些形状作为示例。 For example, the cartridge 20 may be oval, square, or rectangular, shape here as an example just to mention some.

[0020] 盒20包括刀轮22和测试环沈，刀轮22具有多个刀对，用于对皮肤进行切缝和收集体液试样，测试环26具有连续的测试区域，该连续的测试区域被分为多个测试段观，用于在测试环沈被组装到框架30时分析体液试样。 [0020] The cartridge 20 includes a cutter wheel 22 and ring test Shen, cutter wheel 22 having a plurality of knives, for lancing skin and collecting a body fluid sample, the test ring 26 having a continuous test area, the test area continuous concept is divided into a plurality of test sections, for being assembled to the frame 30 in the body fluid sample analysis test loop sink.盒20也包括框架30，所述框架30限定多个室或者舱室32，用于以无菌方式存储单独的刀M。 20 also includes a cartridge frame 30, the frame 30 defines a plurality of chambers or compartments 32 for storage in a sterile manner separate knife M.如以下更为详细描述的那样，盒20 可以包括可破坏的无菌片40，以密封单独的刀24。 As described in more detail above, the cartridge 20 may include sterile breakable sheets 40, 24 to seal the individual knives.多个室32将测试段中的每一个28与单独的刀M对齐。 Each individual blade 28 is aligned with a plurality of chambers 32 M in the test section.框架30与装蛋箱的设计相似，利用将刀轮22装入到多个室32中的嵌入或者模块化设计，框架20的类似装蛋箱的设计允许将刀轮22快速地与框架30组装到一起。 And frame 30 is similar to an egg crate design, similar to the use of an egg crate design of the cutter wheel 32 is loaded into the plurality of chambers 22 embedded or modular design, the frame 20 allows the cutter wheel 22 fast with the frame 30 is assembled together.框架30也限定多个开口34，所述开口34的尺寸设定成接纳驱动器36。 The frame 30 also defines a plurality of openings 34, the size of the opening 34 of the driver 36 is set to receive.每个室32与框架30上的开口34中的一个对齐。 Each chamber 32 is aligned with the opening 34 in the frame 30 a.驱动器36被设定尺寸和构造成延伸通过开口34中的一个并且进入室32的对应的一个中，以接合和移动刀M来在皮肤中形成切口。 Driver 36 is sized and configured to extend through an opening 34 and into a corresponding compartment 32, to engage and move the knife M to form an incision in skin.驱动器36在功能中可以是半自动或者全自动的，并且驱动器36可以是如下所描述的调配和/或致动系统的一部分。 Drive 36 may be a function in the semiautomatic or fully automatic, and the driver 36 may be formulated as described below and / or a portion of the actuation system.驱动器36包括尖端或锐端，以穿透放置在开口34之上的第二无菌片40，如下所述。 Drive 36 includes a tip or a sharp end to pierce second sterile sheet 34 is placed over the opening 40, as described below.盒20包括定位成覆盖和密封框架30的多个室32的一侧的第一无菌片38。 20 includes a first cartridge positioned to the side of the sterile cover sheet and the sealing frame 32 of a plurality of chambers 30, 38.盒20也包括定位成覆盖和密封框架30的多个开口34的第二可破坏的无菌片40。 Box 20 also includes a sterility sheet 40 is positioned to cover and seal the plurality of breakable second frame 34 of the opening 30.测试环沈被构造成覆盖和密封框架30的多个室32的剩余侧。 Shen test ring is configured to cover and seal the remaining sides 32 of the frame 30 of a plurality of chambers.在多个室32和多个开口34上的第一无菌片38、第二无菌片40以及测试环沈的组合保持多个刀M的无菌并且控制多个测试段观所经受的湿度。 A first plurality of chambers in the sterility sheet 32 ​​and a plurality of openings 34, 38, 40 and second sterile sheet composition remains sterile test loop sink plurality of knives M and controls the plurality of test sections humidity experienced Concept .用于第一无菌片38和第二无菌片40的示例材料包括塑料、金属、纸和/或者其他材料。 Examples of materials for the first sheet 38 and second sterile sterility sheet 40 include plastic, metal, paper and / or other materials.在一个实施例中，第一无菌片38和第二无菌片40各自均由具有小于12微米厚度的镀铝聚对苯二甲酸乙二醇酯制造。 In one embodiment, the sterility sheet 38 of the first sheet 40 and second sterile by each aluminum having a thickness of less than 12 microns polyethylene terephthalate manufacture.此外，在该实施例中，测试环沈由具有小于125微米的厚度的、镀聚乙烯的聚对苯二甲酸乙二醇酯制造。 Further, in this embodiment, a test ring made by Shen ester having a thickness of less than 125 microns, polyethylene coated polyethylene terephthalate.必须理解，第一无菌片38、第二无菌片40和测试环沈可以由其他材料所制造。 It must be understood, the first sterility sheet 38, sheet 40 and second sterile test ring sink may be fabricated from other materials.

[0021] 如图3、图4、图5和图6中所示，刀轮22包括刀缘23，所述刀缘23具有多个从刀缘23径向向内延伸的刀M。 [0021] As shown in FIG 3, FIG 4, FIG 5 and FIG 6, cutter wheel 22 includes cutter edge 23, said blade having a plurality of knife edge 23 extending radially inward from the blade edge 23 M.换言之，多个刀M从刀缘23朝向刀轮22的中心延伸。 In other words, a plurality of cutter knives M 23 toward the center of the wheel 22 extends from the edge of the knife.

[0022] 每个刀M具有柔韧性腿部42、接触部分44和刀尖46。 [0022] M each blade having a flexible leg portion 42, the contact portion 44 and tip 46.腿部42大体是直的，但是， 在另一种形式中，腿部42可以是曲线的或者弯曲的，或者另外设计成提供弹簧状的连杆。 A generally straight leg portion 42, however, in another form, the leg portion 42 may be curved or bent, or otherwise designed to provide a spring-like link.腿部42从刀缘23延伸到接触部分44。 The knife edge 42 extends from the leg portion 23 to the contact portion 44.接触部分44在腿部42和刀尖46之间形成第一角θ，如图6中所示。 A first contact portion 44 formed an angle θ between the leg 42 and the tip 46, as shown in FIG. 6.在一个实施例中，第一角θ是大约90度的角。 In one embodiment, the first angle θ is approximately 90 degrees.在其他实施例中，第一角θ可以是在0度和270度之间的另一角度。 In other embodiments, the first angle θ may be another angle between 0 degrees and 270 degrees.刀M被构造成使得接触部分44被定位成接触一个测试段观。 M is configured such that the blade contact portion 44 is positioned to contact a test section concept.腿部42与框架30的壁50的边缘形成第二角β，如下面将更为详细地描述。 Edge of the frame legs 42 and 30 of the wall 50 forms a second angle β, as will be described in more detail below.如图6中所示，第二角β是锐角。 As shown in FIG. 6, the second angle β is acute.

[0023] 刀尖46限定毛细槽48，其尺寸设定成通过毛细作用抽吸体液试样从而收集体液试样。 [0023] The tip 46 defines a capillary groove 48, which is sized to so as to collect a body fluid sample suction body fluid sample by capillary action.在一个实施例中，毛细槽48涂布有亲水材料以增强槽48的毛细作用。 In one embodiment, capillary groove 48 is coated with a hydrophilic material to enhance the capillary action of the groove 48.毛细槽48可以位于刀尖46的前侧或者后侧。 Capillary groove 48 may be located on the front side or the rear side of the cutting edge 46.毛细槽48可以是敞开的、封闭的、或者敞开和封闭的毛细管的组合，以便在其中抽吸体液试样。 Capillary groove 48 may be open, closed, or a combination of open and closed capillaries, so that the suction body fluid sample therein.典型地，毛细槽48位于刀尖46的内侧面上并且是敞开的毛细管。 Typically, the capillary 48 is located in the groove 46 and the inner surface of the tip is open capillary.必须理解，敞开的毛细管更加易于制造，这是因为所述敞开的毛细管能够更容易地形成。 It must be understood, open capillary easier to manufacture, since the open capillary can be more easily formed.例如，可以通过蚀刻刀尖46的表面以及移除材料来产生敞开的毛细管从而形成所述敞开的毛细管。 For example, open capillary can be produced by etching the surface of the cutting edge 46 and removing material to form the open capillary.此外，敞开的毛细槽收集从切口下的皮肤表面之下抽吸的体液。 In addition, open capillary grooves collecting aspirant from beneath the skin incision surface of the lower body fluid.毛细槽48从刀尖46延伸到接触部分44中，使得当接触部分44接触测试段观时，容纳在毛细槽48中的体液试样通过流体接触而释放到测试段28上。 Capillary groove 48 extends from tip 46 to the contact portion 44, such that when the concept of the contact portion 44 contact with the test section, housed in the body fluid sample capillary groove 48 is released to the test section 28 by the fluid contact.多个刀M中的毛细槽48可以通过冲压、蚀刻、雕刻、或者它们的包括其他技术的组合来制造。 A plurality of capillary grooves 48 in tool M may be manufactured by stamping, etching, engraving, or combinations thereof including other techniques.

[0024] 具有多个刀M的刀轮22可以由单件材料制造，例如金属、塑料、或者它们的包括其他材料的组合。 [0024] The cutter wheel 22 having a plurality of tool M may be manufactured by a single piece of material, such as metal, plastic, or combinations thereof comprise other materials.在一个实施例中，刀轮22通过蚀刻、冲压或者激光切割金属板并且移除金属板的一部分以暴露出多个刀M而形成。 In one embodiment, the cutter wheels cut metal plate 22 is formed by etching, punching or laser cutter and removed to expose the plurality of portion of the metal plate M.毛细槽48通过蚀刻、激光切割、或者形成多个刀尖46来暴露毛细槽48，同时随着多个刀M的形成而形成，或者在形成刀M之后来形成。 Capillary groove 48 by etching, laser cutting, or cutting edge 46 is formed to expose a plurality of capillary groove 48, simultaneously with the formation of M is formed a plurality of knives, the knife is formed or later formed of M.多个刀M的每个在接触部分44处被弯曲以形成第一角θ，并且多个刀M的每个在边缘23 处被弯曲以形成第二角β。 Each M in the plurality of blade contact portion 44 is bent to form a first angle θ, and each of the plurality of knives M at the edge 23 is bent to form a second angle β.多个刀M的每个从边缘23辐射状地延伸到刀轮22的中心。 23 extending radially from the edge to the center of each cutter wheel 22 of a plurality of knives M.在另一实施例中，刀轮22可以通过将多个刀M附接到边缘23来制造。 In another embodiment, the cutter wheel 22 may be formed by attaching a plurality of knife edges 23 M manufactured.必须了解，在其他实施例中，刀轮22通过其他制造技术来形成。 It must be appreciated that in other embodiments, cutter wheel 22 is formed by other manufacturing techniques.

[0025] 如前面所提及且如图1中所示，测试环沈包括多个测试段观，用于测试体液或者生物流体，例如来自切口的血液、间质液以及其他流体。 [0025] As previously mentioned and shown in Figure 1, comprises a plurality of test test ring concept Shen segments for testing body fluids or biological fluids, such as blood from the incision, interstitial fluid and other fluids.用于图1、图2的实施例的测试段28将参照光学测试条来描述，但是必须认识到，测试段观可以其他方式来分析体液试样，作为示例提及的一些技术，例如通过电流测定法、库伦测定法、或者反射率光度测定法。 For FIGS. 1 and 2 of the test section 28 of the embodiment described with reference to an optical test strip, but it must be recognized that the concept of test section may otherwise be analyzed body fluid sample, mentioned as an example of some techniques, such as by current assay, Coulomb assay, or reflectance photometry.必须认识到，光学测试条可以通过电荷耦合装置（CCD )和/或者颜色捕获装置来分析，并且直方图读取器可以用来显示该测试结果。 It must be recognized that the test strip can be optically and / or by a charge coupled device color capture device (CCD) to analyze the histogram and the reader can be used to display the test results.

[0026] 在所示的实施例中，多个测试段观采用了安装在或者施加到膜上的化学物的连续的条或者环的形式。 [0026] In the embodiment shown, the concept of a plurality of test sections takes the form of a continuous strip or ring is attached to the film or applying chemicals.在图1中，测试环沈包括印刷到其上的标记线四以区分单独的测试段观，但是在其他实施例中，标记线四是可任选的。 In FIG 1, test loop to sink comprises a printed marking line on which the four separate concept to distinguish the test section, but in other embodiments, four marking line is optional.每个测试段28都位于室32中的一个内，并且与刀M中的一个的接触部分44相邻和/或接触地定位。 32 in a section 28 are located in each test chamber and in contact with the knife of one of M adjacent portion 44 and / or positioned in contact.在切缝和测试事件之前，刀M的接触部分44和测试段观之间的摩擦可能损坏测试段观上的化学物并且影响对体液试样的分析。 Before lancing and testing event, the contact friction between the knife and the test concept M segment portion 44 may damage the chemicals on the test section and impact analysis of the concept of a body fluid sample.在该实施例中，多个测试段观包括薄的可溶解层，以便在切缝和测试事件之前保护多个测试段观上的化学物并且防止由刀M的接触部分44与多个测试段观上的化学物的摩擦或碾擦所导致的测试错误。 In this embodiment, a plurality of test sections includes a thin concept soluble layer in order to protect the plurality of test chemicals on the concept of segments before lancing and testing event and to prevent contact of the blade portion 44 with a plurality of M test sections Rolling friction rub test error or chemicals on the resulting View.在切缝和测试事件期间，该薄的可溶解层不会与化学物相干涉或者影响对体液试样的分析结果。 During lancing and testing event, the thin dissolvable layer does not interfere or affect the analysis results of the body fluid sample with chemicals.在另一实施例中，每个测试段观不接触接触部分44，而是可破坏的突起49定位在刀M和测试段28之间以使接触部分44从测试段观升离。 In another embodiment, each segment organoleptic test does not contact the contact portion 44, but destructible projection 49 is positioned between the knife and the test section 28 M so that the contact portion 44 is lifted off from the concept of the test section.可破坏的突起49保持在位，直到驱动器36接合刀M的腿部42时为止。 It can damage the projection 49 is held in place until the driver 36 engages knife 42 until the leg M.测试环沈被构造成覆盖和密封框架30的一侧和多个室32的对应一侧。 Shen test ring is configured to correspond to the side cover and seal the side of the frame 30 and a plurality of chambers 32.在一个实施例中，测试环沈包括以条形码或者射频识别（RFID)芯片形式的化学物批次编码（lot coding),以便为多个测试段观以传统格式存储有关化学物批次的标定(或校准）的信息。 In one embodiment, the test loop sink includes a bar code or radio frequency identification (RFID) chip in the form of chemical batch code (lot coding), in order to test a plurality of memory segments to the conventional concept of calibration related chemical format batch ( or calibration) information.

[0027] 如图1、图2和图7中所显示，框架30包括多个轮辐或者壁50，所述轮辐或者壁50 被构造成限定多个室32，其中每个所述室32的尺寸设定成容纳刀M中的一个。 [0027] As shown in FIG 1, FIG 2 and FIG. 7 shows the frame 30 or wall 50 comprises a plurality of spokes, the spokes or wall 50 is configured to define a plurality of chambers 32, wherein a size of each of the chamber 32 into a set of M receive knife.多个壁50 隔离多个刀M并保持多个刀M的无菌。 A plurality of spacer walls 50 and a plurality of knife holding M M sterile plurality of knives.此外，由于刀M返回到其在室32中的原始的切口形成前位置，所以多个壁50通过防止被使用和未使用（无菌)的刀之间的接触还防止了对无菌的刀M的污染。 Further, since the return to the original M knife slit 32 in its forward position in the chamber is formed, so that a plurality of wall 50 by preventing contact between the knife was used and unused (sterile) also prevents the blade of the sterile M pollution.框架30是圆形的，而每个室32是梯形或者楔形的。 Frame 30 is circular, while each chamber 32 is wedge-shaped or trapezoidal.在一种形式中， 框架30大致是38毫米的直径，3-5毫米高，并且包括25个室以存储25个刀M和25个测试段观。 In one form, the frame 30 is approximately 38 mm in diameter, 3-5 mm high and comprises 25 to storage chamber 25 and the knife 25 M test View segments.在其他形式中，框架30和室32可以不同地成形。 In other forms, the frame 30 and the chamber 32 may be shaped differently.例如，框架30和/或者室32可以具有矩形、椭圆形和/或者三角形的形状。 For example, the frame 30 and / or the chamber 32 may have a rectangular, oval and / or triangular shape.

[0028] 如图2、图7中所示，框架30也包括位于框架30中心附近的多个内部传动装置52。 [0028] As shown in FIG 2, as illustrated in frame 30 of FIG 7 also includes a plurality of internal gearing 52 located near the center of the frame 30.每个内部传动装置52与室32中的一个相邻定位。 A 32 located adjacent each chamber 52 and the internal gear.传动装置52紧邻室32的放置使得主轴或者其他接合机构来接合传动装置52从而旋转框架30，以便使后续的室32以及对应的开口34与驱动器36成一直线。 A transmission chamber 52 disposed adjacent to the spindle 32 so that engagement or other engagement mechanism 52 to rotate the gear frame 30, so that the subsequent chamber 32 and a corresponding opening 34 of the driver 36 in a straight line.传动装置52可以定位在框架30上的其他位置处，且传动装置52可以不同地构造以在其他实施例中接合其他旋转机构。 Transmission means 52 on the frame 30 may be positioned at other locations, and the transmission means 52 may be variously configured to engage the other rotation mechanism in other embodiments.多个内部传动装置52中的每个形状是三角形的形状，然而在其他实施例中，多个内部传动装置52可以不同地成形。 Each shape of the plurality of internal gear 52 is triangular in shape, however, in other embodiments, the plurality of internal gearing 52 can be shaped differently.例如，多个内部传动装置52可以具有圆形、矩形和/或者卵形的形状。 For example, a plurality of internal gear 52 may have a circular, rectangular and / or oval.在另一示例中，多个内部传动装置52调配盒20，以便提供仅一个途径将盒20插入到计量器66中，如以下讨论的那样。 In another example, the plurality of internal gearing 52 deployment cartridge 20, only a way to provide the cartridge 20 is inserted into the meter 66, as discussed below.

[0029] 框架30还包括在外部的框架边缘53以及在内部的毂M，如图2、图7中所示。 [0029] The frame 30 further includes the edge of the outer frame 53 and the inside of the hub M, FIG. 2, FIG. 7.框架边缘53限定多个开口34，使得每个开口34对应室32中的一个。 Frame edge 53 defines a plurality of openings 34, 34 such that each opening corresponds to a chamber 32 in the.每个开口34的形状是圆形的，但是在其他实施例中，开口34可以不同地成形。 The shape of each opening 34 is circular, in other embodiments, the opening 34 can be shaped differently.作为示例来提及一些形状，例如， 开口34中的每个可以具有卵形、椭圆形、和/或者矩形的形状。 Mentioned as examples of some shape, an oval and / or rectangular shape, for example, each of the openings 34 may have an oval.在另一示例中，每个开口34 是敞开到框架30的底部的，以便对框架30提供更容易的模制。 In another example, each opening 34 is open to the bottom frame 30 so as to provide for easier molding of the frame 30.此外，每个开口34的尺寸设定成接纳驱动器36。 In addition, each size of the opening 34 of the driver 36 is set to receive.轮毂M的形状是圆形的，用于将框架30安装到主轴或者其他可旋转机构上。 M shape of the hub is circular, for the frame 30 is mounted on the spindle or other rotating mechanism.毂M可以在其他实施例中不同地成形。 M may be hub shaped differently in other embodiments.

[0030] 在一个实施例中，框架30由填充了干燥剂的塑料构造，该填充了干燥剂的塑料被模制成盘形框架。 [0030] In one embodiment, the frame 30 is filled by the plastic structure desiccant, the desiccant filled plastic is molded into a disk-shaped frame.在其他的实施例中，框架30可以由例如金属、木材、陶瓷、塑料、其他材料和/或者其复合物制造。 In other embodiments, the frame 30 may, other materials and / or composites thereof, for example, made from metal, wood, ceramic, plastic.在另一实施例中，框架30包括添加到每个室32中的单独的干燥剂楔形块或者干燥剂颗粒。 In another embodiment, the frame 30 includes a desiccant added to separate the wedge block 32 or the desiccant particles in each chamber.此外，框架30可以由其他技术来构造，例如通过胶粘、焊接、或者用于附接的一些其他机制来将多个壁50和多个内部传动装置52附接到毂54。 Further, the frame 30 may be constructed by other techniques, for example, a plurality of internal gear 50 and a plurality of wall 52 is attached to the hub 54 by gluing, welding, or some other mechanism for attachment.在一种形式中，框架30使用在线电子束（e-beam)灭菌工艺来灭菌。 In one form, the frame 30 using an electron beam-line (e-beam) sterilized sterilization process.框架30也能够以其他方式进行灭菌，例如，经由伽马辐射或紫外光灭菌技术。 Frame 30 can be sterilized in other manner, e.g., via UV light or gamma radiation sterilization techniques.此外，框架30也可以在各组装阶段中的任一个处进行灭菌。 Further, a frame 30 may be at any stage in the assembly is also sterilized.

[0031] 如图8、图9和图10中所示，盒20被装载到计量器66中。 [0031] FIG. 8, as shown in FIGS. 9 and 10, the cartridge 20 is loaded into the meter 66.计量器66可以被构造成显示体液试样的分析结果。 Meter 66 may be configured to display the results of the analysis of body fluid sample.计量器66包括致动机构60。 Meter 66 comprises an actuating mechanism 60.在一个实施例中，致动机构60 接合且移动驱动器36，以接合刀M中的一个。 In one embodiment, the actuating mechanism 60 engages and moves driver 36 in order to engage a blade of M.在另一实施例中，致动机构60调配框架30， 以将驱动器36定位成与未使用的刀M的开口34相邻。 In another embodiment, the deployment actuator 60 frame moving mechanism 30, the opening 34 to drive knife 36 is positioned adjacent M unused.正如应当认识到的那样，在一个实施例中，致动机构60接合和移动驱动器36，并且致动机构60还调配框架30。 As it should be appreciated, in one embodiment, the actuating mechanism 60 and the movement of the driver 36 engages, and the actuating mechanism 60 further deployment frame 30.尽管计量器66未整体上显示，但是必须理解的是，计量器66覆盖和封装盒20、驱动器36和致动机构60。 Although shown on the meter 66 is not integral, it must be understood that the meter cover 66 and the sealing case 20, the drive mechanism 36 and the actuator 60.计量器66可以是各种形状，作为示例来提及一些形状，例如矩形、三角形、圆形和/或者椭圆形。 Meter 66 may be of various shapes, as examples refer to some shapes such as rectangular, triangular, circular and / or elliptical.计量器66可以由各种材料制造，例如塑料、金属和/或者其他材料。 Meter 66 may be manufactured from various materials, such as plastic, metal, and / or other materials.

[0032] 在图10所示的实施例中，计量器66包括在切缝期间靠着切口放置的切缝帽62。 [0032] In the embodiment illustrated in FIG. 10, the meter 66 includes a cutout positioned against the lancing cap 62 during lancing.切缝帽62限定了切口位置开口64。 Lancing cap 62 defines an opening 64 of the incision site.如所应当理解的那样，用户将待切缝的合适的身体部位放置在切口位置开口64上，并且刀尖46穿过切口位置开口64以在用户中形成切口。 Suitable parts of the body as will be appreciated by the user to be placed in slit 64 on the slit opening position, and the position of the cutting edge 46 through the incision 64 to form an incision in the user opening.切缝帽62形成渐缩的圆形，但是可以在其他实施例中不同地成形。 Lancing cap 62 is formed a tapered circular, but may be shaped differently in other embodiments.例如，切缝帽62可以是金字塔形、U形、卵形、圆形、或者一些其他形状。 For example, lancing cap 62 may be pyramid-shaped, U-shaped, oval, circular, or some other shape.切口位置开口64的形状也是圆形的，但是可以在其他实施例中不同地成形。 The shape of the notch position of the opening 64 is circular, but may be shaped differently in other embodiments.切缝帽62可以由各种材料形成，例如塑料、金属和/或者其他材料。 Lancing cap 62 may be formed of various materials, such as plastic, metal, and / or other materials.在一个实施例中，切缝帽62被构造成调整刀尖46的穿刺深度。 In one embodiment, the lancing cap 62 is configured to adjust the depth of lancing tip 46.在一个示例中，切缝帽62被螺纹连接到计量器66中。 In one example, the lancing cap 62 is connected to the metering screw 66.螺纹接合允许切缝帽62相对于计量器66移动，以控制刀尖46的穿刺深度。 Threaded engagement allows lancing cap 62 to move relative to the meter 66, 46 to control the penetration depth of the tip.

[0033] 在另一实施例中，切缝帽62被构造成检测用户开始切缝所需的力。 [0033] In another embodiment, the lancing cap 62 is configured to detect a user starts the force required to shear joints.切缝帽62还能够将通过切缝帽62的皮肤屈曲控制至已知的变化程度或者深度。 Lancing cap 62 can be further controlled to a known degree of flexion changes or through the skin depth of the lancing cap 62.此外，切缝深度可以通过驱动器36接合刀M的行进量来控制，其中驱动器36的运动范围由用户来设定。 Further, the slit depth may be controlled by the amount of travel of the knife 36 engages a drive M, wherein the range of motion of the driver 36 is set by the user.此外， 驱动器36能够以线性径向运动、具有偏心形状的旋转运动、或者使柔韧性腿部42升举或下降的翻倾运动来进行移动。 Further, the driver 36 can be a linear radial movement, with a rotating motion of the eccentric shape, the flexibility of the legs 42 or to the lifting or lowering movement of the tilting movement is performed.

[0034] 为了使用盒20，用户将待切缝的身体部位(最可能是手指）放在切口位置开口64 之上。 [0034] In order to use the cartridge 20, the user will be slit parts of the body (most likely a finger) is placed above the opening incision 64.驱动器36被致动以刺穿第二无菌片40、通过对应的开口34并进入室32。 Drive 36 is actuated to pierce second sterile sheet 40, through the corresponding opening 34 and into the chamber 32.驱动器36 继续移动到室32中，并且驱动器36接合起作用的刀M的腿部42。 Driver 36 continue to move into the chamber 32, and the engagement leg portion 36 of the M 42 function knife drive.随着驱动器36接合腿部42，驱动器36将力施加到腿部42，以沿着垂直于框架30的方向移动刀尖46。 As the leg portion 36 engages the driver 42, the driver 36 applies a force to the leg portion 42 to tip 46 to move the frame 30 along the vertical direction.随着刀尖46移动，刀尖46穿透第一无菌片38并且继续进入到已经被放置在切口位置开口64之上的用户的皮肤内。 With the movement of tip 46, tip 46 penetrates the first sterility sheet 38 and proceeds to the incision site has been placed over the opening 64 in the skin of the user.在一个实施例中，当刀尖46形成切口时，来自切口的体液试样通过毛细作用沿着毛细槽48朝向接触部分44行进，从而毛细槽48在刀尖46位于用户的皮肤内时从切口收集体液试样。 In one embodiment, the notch 46 is formed when the tip, body fluid sample from the incision contact portion 44 toward the groove 48 travels along the capillary by capillary action, the capillary groove 48 so that nose 46 is located within the skin of the user from the notch collecting body fluid sample.在驱动器36到达其最大延伸位置后，驱动器36停止并且使其运动路径反向。 After the driver 36 reaches its maximum extended position, the driver 36 is stopped and reversed so that the path of movement.当驱动器36使其运动路径反向时，施加到腿部42的力减小并且刀尖46从切口缩回。 When the driver 36 so that the reverse path of movement, the force applied to the leg portion 42 is reduced and the tip 46 is retracted from the incision.在另一实施例中，毛细槽48在刀尖46返回到其在室32中的原始位置时收集体液试样，如下面将描述的那样。 In another embodiment, the capillary channel 48 to collect body fluid sample 46 when the tip 32 is returned to its original position in the chamber, as will be described below.随着驱动器36继续使其行进方向反向，该运动可以被减慢，以便允许刀尖46在刀尖46返回到其位于室32中的原始位置之前有足够的时间来填充毛细槽48。 As driver 36 continues to reverse the direction of travel so that the movement may be slowed to allow sufficient time prior to tip 46 to the return chamber 32 which is located in the original position in the capillary tip to fill the 46 slots 48.由于每个刀M的弹性属性，所以刀尖46自身弹回到其位于室32中的原始位置。 Since the elastic properties of each knife M, so that tip 46 itself spring back to the chamber 32 which is located in the original position.在一个实施例中，如果通过刀尖46所形成的第一切口深度太浅从而难以为测试段观提供足够量的体液试样以产生准确的测试结果，那么刀尖46可以在致动机构60旋转框架30之前如上所述地在皮肤中形成第二切口。 In one embodiment, if the depth of the first notch formed by the cutting edge 46 is too shallow it becomes difficult to provide a sufficient amount of body fluid sample to produce a test period concept accurate test results, the tip 46 may be actuated mechanism rotating frame 60 is formed as described above prior to a second incision in skin 30.在其最终的歇置位置中，起作用的刀M的接触部分44 接触测试段观，并且体液试样通过刀M的接触部分44和测试段观上的化学物之间的优先毛细管作用从毛细槽48释放到测试段观上。 Rest in its final set position, the acting portion 44 contacts the contact blade M concept test section, and the body fluid sample by capillary action between the priority chemical M on the contact blade portion 44 and the test section from the capillary View groove 48 is released to the test section View.刀M保持在其最终的歇置位置中，其中接触部分44靠着测试段观歇置。 M knife is held in its final rest position is set, wherein the contact portion 44 against the concept of the test section rest position.对于下一次测试，致动机构60通过内部传动装置52或者另一调配机构来旋转框架30。 For the next test, the actuating mechanism 60 through the internal gear 52 or another deployment mechanism 30 to rotate the frame.致动机构60缩回驱动器36且旋转框架30，以将下一个对应的开口34和下一个未使用或者无菌的刀M与驱动器36对齐。 Retraction of the actuating mechanism 60 drives the rotation frame 36 and 30, next to the opening 34 and corresponding to the next unused or sterilized knife 36 is aligned with the driver M.

[0035] 根据一个实施例的盒120显示在图11、图12、图13、图14、图15、图16、图17、图18和图19中。 [0035] According to one embodiment of the cartridge 120 shown in FIG 11, FIG 12, FIG 13, FIG 14, FIG 15, FIG 16, FIG 17, FIG 18 and FIG 19.盒120与盒20相似，因此为了简洁起见，盒120中与盒20相似的特征将不再讨论。 Cartridge 120 is similar to cartridge 20, so for brevity, the cartridge 120 and the cartridge 20 similar features will not be discussed.与盒20相似，盒120包括第一无菌片138，所述第一无菌片138定位成覆盖和密封框架130的多个室132的一侧。 20 is similar to the cartridge, the cartridge 120 includes a first sheet 138 sterile, sterility of the first side plate 138 positioned to cover and seal the plurality of chambers 130 of the frame 132.但是，盒120包括第二无菌片140，所述第二无菌片140定位成覆盖和密封多个开口134以及覆盖和密封多个室132的另一侧。 However, the cartridge 120 comprises a second sterile sheet 140, the second sterile sheet 140 positioned to the other side of the opening 134 and the chamber 132 to cover and seal a plurality of a plurality of covered and sealed.在另一形式中，测试环1¾和第二无菌片140被构造成覆盖和密封多个室132的相同侧。 In another form, and a second sterile test ring 1¾ sheet 140 is configured to cover and seal the same side of the plurality of chambers 132.在一个实施例中，第二无菌片140由具有25微米厚度的铝箔制造，第二无菌片140被热封在框架130之上以单独地密封每个室132。 In one embodiment, the second sterile sheet of aluminum foil 140 having a thickness of 25 microns by the second sterile sheet 140 is heat-sealed over the frame 130 to individually seal each chamber 132.

[0036] 刀轮122与刀轮22相似。 [0036] The cutter wheel 122 is similar to the cutter wheel 22.与刀轮22相似，刀轮122包括刀缘123，刀缘123具有多个从刀缘123径向向内延伸的刀124。 Similar to cutter wheel 22, wheel 122 includes a knife edge knife 123, knife edge 123 having a plurality of knife edges 123 that extend radially inwardly from the blade 124.与刀轮22相似，每个刀IM包括柔韧性腿部142、 接触部分144和刀尖146。 22 is similar to the cutter wheel, each blade comprising a flexible IM leg portion 142, the contact portion 144 and tip 146.但是，每个刀124的接触部分144是弯曲的，并且尺寸设定成在刀1¾是歇置时歇置在盖阻挡件156上。 However, the contact portion 144 of each blade 124 is curved and sized to rest on the knife is set at 1¾ rest stopper member 156 opposite the lid.此外，当致动刀时，接触部分144配合在盖阻挡件156的窗口157内，如下所描述地。 Further, when the activated tool, mating contact portions 144 of the cover block 157, as described below window member 156.柔韧性腿部142的弹性力将力施加到盖阻挡件156，以相对于测试段1¾挤压盖阻挡件156，直到刀IM通过驱动器136来致动时为止。 Flexible leg 142 will force the elastic force to the lid stopper member 156 with respect to the test section 1¾ pressing lid stopper member 156, until such time as the knife through the IM driver 136 is actuated.每个刀124也限定了尺寸设定成接纳驱动器136的槽147，如下将更详细地描述。 Each blade 124 also defines sized to receive the drive bay 147 136, as described in more detail.与刀尖46相似， 刀尖146限定了毛细槽148。 Similar to the tip 46, tip 146 defines a capillary groove 148.

[0037] 测试环1¾与测试环沈相似，但是多个测试段1¾是采用了安装在或者施加到膜上的化学物的连续环的形式。 [0037] and the test loop test loop 1¾ Shen similar, but uses a plurality of test sections 1¾ form a continuous loop mounted to the film or applying chemicals.在一种形式中，化学物涂层被施加到由具有250微米厚度的聚对苯二甲酸乙二醇酯所形成的膜。 In one form, the chemical coating is applied to the film made of polyethylene terephthalate having a thickness of 250 microns being formed.测试环126附接到第二无菌片140。 Test ring 126 is attached a second sheet 140 sterile.如图13、图14中所显示地，限定了多个窗口157的多个盖阻挡件156定位在多个刀124的接触部分144之下的测试环1¾上。 13, shown in FIG. 14, a plurality of windows 157 define a plurality of barrier cover member 156 is positioned below the test loop 1¾ plurality of the contact portion 144 of the knife 124.多个盖阻挡件156通过在刀124的致动之前消除测试环1¾和刀124 之间的接触来保护和覆盖测试环126上的化学物。 A plurality of lid stopper member 156 by eliminating the contact between the test ring 124 and 1¾ knife blade 124 prior to actuation of the protective cover and the chemicals on the test ring 126.此外，每个盖阻挡件156被构造成覆盖一个测试段128，测试段128由多个分度线129限定。 In addition, each lid stopper member 156 is configured to cover a test section 128, the test section 128 is defined by a plurality of dividing line 129.当刀IM通过驱动器136来致动时， 驱动器136滑动通过刀IM的槽147并且结合盖阻挡件156，以跨越测试段1¾来推动盖阻挡件156，由此将窗口157定位在框架窗口161 (如下所描述）和测试段1¾之上。 When the knife IM by the driver actuated 136, the driver 136 slides through knife IM slot 147 and binds the lid stopper member 156 to span the test section 1¾ to push the lid stopper member 156, thereby the window 157 positioned in the frame window 161 ( as described above) and the test section 1¾.在所显示的实施例中，驱动器136还将盖阻挡件156推到由干燥剂材料制造的对应楔形件159下。 In the embodiment shown, the driver 136 will cover the stopper member 156 pushed to the corresponding wedge member 159 made of a desiccant material.刀1¾在皮肤中形成切口，并且相似地收集体液试样至刀对，如上所述。 1¾ blade forming an incision in the skin and collecting a body fluid sample to similarly knife pairs, as described above.在刀1¾形成切口且收集体液试样之后，接触部分144通过窗口157和框架窗口161 (如下所描述）接触测试段1¾并且将体液试样沉积到测试段1¾上。 1¾ knife an incision and thereafter collecting a body fluid sample, the contact portion 144 through the window 157 and the window frame 161 (as described below) and contacted with the test section 1¾ depositing a body fluid sample to the test section 1¾.

[0038] 在所示的实施例中，盒120包括由干燥剂材料制造的多个楔形件159。 [0038] In the embodiment shown, the cartridge 120 includes a plurality of wedges 159 manufactured by the desiccant material.每个楔形件159被定位在框架130的每个室132中，相邻于刀尖146。 Each wedge 159 is positioned in chamber 132 of each frame 130, 146 adjacent to the tip.

[0039] 框架130与框架30相似。 [0039] The frame 130 and the frame 30 is similar.框架130包括限定多个室132的多个壁150。 Frame 130 comprises a plurality of wall 132 defines a plurality of chambers 150.框架130 包括限定多个开口Π4的上边缘153。 Frame 130 includes an upper edge defining a plurality of openings 153 Π4.每个开口134与对应的室132连接。 Each opening 134 is connected with a corresponding chamber 132.如所理解地， 由于开口134中的每一个与所述室132中的一个连接，所以简化了框架130的制造。 As will be appreciated, since each of the one connecting opening 134 of the chamber 132, thus simplifying the manufacture of the frame 130.在所示的实施例中，每个开口Π4具有半圆形形状，但是在其他实施例中，开口134不同地成形。 In the embodiment shown, each opening has a semicircular shape Π4, in other embodiments, openings 134 are shaped differently.框架130也包括下边缘155，所述下边缘155限定多个框架窗口161，用于允许刀124的接触部分144和测试段1¾之间的接触，在所述测试段1¾中，来自接触部分144的体液试样通过窗口157和框架窗口161被传输到测试段128。 Frame 130 also includes a lower edge 155, lower edge 155 of the window 161 defines a plurality of frames, for 1¾ allow contact between the contact blade portions 144 and 124 of the test section, said test section 1¾, the contact portion 144 from 161 is a body fluid sample to the test section 128 through the window 157 and the window frame.在所示的实施例中，下边缘155大体上是平坦的。 In the illustrated embodiment, the lower edge 155 is substantially flat.在其他的实施例中，下边缘155是弯曲的。 In other embodiments, the lower edge 155 is curved.

[0040] 在该实施例中，框架130由聚丙烯制造且由注塑成形技术所构造。 [0040] In this embodiment, the frame 130 made of polypropylene and manufactured by the injection molding technique configuration.在其他实施例中，框架130由如上所述的其他材料和其他技术来制造。 In other embodiments, the frame 130 be made of other materials as described above, and other techniques.

[0041] 框架130也包括多个与内部传动装置52相似的内部传动装置152。 [0041] The frame 130 also comprises a similar plurality of inner transmission device 152 inside the drive device 52.框架130也包括在框架130的内部或者中心上的毂154。 Frame 130 also includes a hub 154 on the interior or the center of the frame 130.毂154与毂M相似。 M is similar to the hub 154 and the hub.

[0042] 如前所述，集成的一次性盒或者盘的第二实施例包括微取样器轮200和测试环或者多个测试段210。 [0042] As described above, the second embodiment of the integrated disposable cassette or disc comprises microsampler wheel 200 and the ring test section 210 or a plurality of test.如所理解地，微取样器轮200上的刀和多个测试段210以交替的方式来取向，如下所描述。 As appreciated, the knife wheel 200 micro-sampler 210 and a plurality of test sections are oriented in an alternating manner, as described below.微取样器轮200的一个实施例图示在图20和图21中。 A micro-sampler 200 according to the illustrated embodiment wheel 21 in FIG. 20 and FIG.微取样器轮200切缝皮肤以形成切口并从所述切口收集体液试样。 Microsampler wheel 200 cut slits the skin to form an incision and collect body fluid sample from the incision.体液试样从微取样器轮200传输到多个测试段210中的一个，其中体液试样被分析。 Microsampler transmitted from a plurality of wheel 200 to a test section 210, wherein the body fluid sample is a body fluid sample is analyzed.

[0043] 微取样器轮200包括与多个微针或者刀204交替的多个肋202。 [0043] microsampler wheel 200 includes a plurality of micro needle or blade 204 alternately a plurality of ribs 202.微取样器轮200 也包括：基部206，多个肋202和多个刀204从所述基部206延伸；以及第一圆柱体208，所述第一圆柱体208被构造成驱动多个刀204中的每个以在皮肤中形成切口。 Microsampler wheel 200 also includes: a base 206, a plurality of ribs 202 and a plurality of knife 204 extends from the base portion 206; and a first cylinder 208, the first cylinder 208 is configured to drive a plurality of knives 204 each notch is formed in the skin to.

[0044] 每个肋202用作相邻的刀204所用的引导件或者参考平面，以确定刀尖226的穿刺深度，如下所描述地。 [0044] Each rib 202 adjacent knife 204 is used as a guide or a reference plane, to determine the depth of the puncture tip 226, as described below.多个肋202的每个是梯形形状的，但是在其他实施例中，每个肋202 可以不同地成形，例如多边形或者卵形，如果要提及一些形状作为示例的话。 Each of the plurality of ribs 202 are trapezoidal shape, in other embodiments, each rib 202 can be differently shaped, for example polygonal or oval, if you want to mention some examples, as the shape of words.此外，多个肋202的每个大体上是扁平的，这有助于让微取样器轮200能够形成整体上简洁的形状。 Further, each of the plurality of ribs 202 are substantially flat, This helps microsampler wheel 200 can be formed on the whole simple shape.此夕卜，每个肋202用作参考平面或者表面，从所述参考平面或者表面可以确定对应的刀尖226 的穿刺深度。 Bu this evening, each rib 202 is used as a reference plane or surface, it may determine the depth of the corresponding puncture tip 226 from the reference plane or surface.

[0045] 每个刀204包括从基部206朝向第一腿构件222延伸的腿部220。 [0045] Each blade 204 includes a leg portion extending from the base 220 222 206 member towards the first leg.第一腿构件222 跨在腿部220和每个刀204的第二腿构件2¾之间。 A first leg member 222 spanning between each blade and the leg portion 220 of the second leg member 204 2¾.第二腿构件2¾跨在第一腿构件222 和每个刀204的刀尖2¾之间。 The second leg member between 2¾ 2¾ cross member 222 and the first leg 204 of each blade tip.如图21中所示，腿部220从基部206延伸，并且与基部206 形成第一角a。 Shown in Figure 21, leg portion 220 extending from the base 206, and forms a first angle with the base 206.第一角α是锐角。 The first angle α is an acute angle.腿部220大体上是直的。 Leg portion 220 substantially straight.第一腿构件222与腿部220 形成第二角S。 A first leg member 222 forming a second angle with the leg portion 220 S.第二角度是钝角，如图所示。 The second angle is an obtuse angle, as shown in FIG.第一腿构件222大体上是直的。 A first leg member 222 is substantially straight.第二腿构件2¾与刀尖2¾形成第三角Y。 2¾ and second leg member is formed of a triangular tip 2¾ Y.第三角γ是钝角。 Third angle γ is obtuse.第二腿构件2¾大体上是直的。 2¾ second leg member are substantially straight.在另一实施例中，第一腿构件222和/或者第二腿构件2M是弯曲的。 In another embodiment, the first leg 222 and / or the second leg member is curved member 2M.[0046] 如图21中所示，刀尖2¾是弯曲的。 [0046] As shown in FIG. 21, the cutting edge is curved 2¾.刀尖226的曲率对应于在刀204的致动和缩回期间刀204所沿循的圆形路径的半径。 Curvature of tip 226 corresponds to the radius of the circular path during actuation and retraction of the knife 204 along which the knife 204.此外，刀尖226的曲率对应于当刀尖2¾在用户的皮肤中形成切口且此后从用户的皮肤中缩回时刀204的运动的曲率。 In addition, the curvature of tip 226 corresponds to a tip 2¾ an incision in the skin of the user, and thereafter the knife is retracted from the skin of the user 204 motion curvature.在另一实施例中， 刀尖2¾是直的。 In another embodiment, 2¾ tip is straight.

[0047] 每个刀204也包括毛细槽228，毛细槽2¾的尺寸设定成从切口或者皮肤表面通过毛细管作用抽吸体液。 [0047] Each blade 204 also includes a capillary groove 228, 2¾ capillary groove is set to be the size of the incision from the skin surface or a body fluid drawn by capillary action.在一个实施例中，毛细槽2¾包括亲水涂层，以沿着毛细槽2¾朝向第二腿构件2M抽吸体液。 In one embodiment, the hydrophilic coating comprises a capillary groove 2¾, toward the second leg member along the capillary grooves 2¾ 2M suction bodily fluids.毛细槽2¾从刀尖2¾延伸到第二腿构件224，如图22、图23 中所示。 2¾ capillary groove extending from the tip of the second leg member 224 to 2¾, 22, 23 shown in FIG.在一些实施例中，毛细管槽2¾从刀尖2¾延伸到第二腿构件2M并进入到第一腿构件222中。 In some embodiments, the capillary channel extending from the tip 2¾ 2¾ to 2M and the second leg member into a first leg member 222.如图22、图23中所示，毛细槽2¾被定位在刀尖226的前侧上。 22, as shown in FIG. 23, 2¾ capillary grooves are positioned on the front side 226 of the tip.在其他的实施例中，毛细槽2¾可以对应于测试段210的放置而定位在刀尖2¾的前侧或者后侧上。 In other embodiments, the capillary grooves may correspond to 2¾ test section 210 is placed and positioned on the front or back side of the nose 2¾.刀尖226的前侧对应于刀204的最远离基部206的面。 The front side of the cutting edge 226 of the blade 204 corresponds to the most remote from the surface of the base 206.刀尖226的后侧对应于刀尖226的与基部206最近的面。 206 nearest the rear surface of the cutting edge 226 corresponding to the tip 226 with the base.

[0048] 如图23中所示，毛细槽2¾形成敞开的取样通道以通过毛细管作用收集体液试样。 [0048] As shown in FIG. 23, open capillary grooves formed 2¾ sampling channels to collect the body fluid sample by capillary action.在另一实施例中，毛细管槽2¾是封闭的。 In another embodiment, the capillary grooves 2¾ is closed.如所理解，当与封闭的毛细管或者通道相比较时，敞开的毛细管槽2¾具有这样的优点：刀204能够以蚀刻工艺更容易地生产。 As will be appreciated, when compared with closed capillary or channel, open capillary grooves 2¾ has the advantage that: a knife etch process 204 can be more easily produced.在刀204中形成毛细槽228的其他示例包括尖点（sharp point)、激光束、或者从刀204移除材料以产生敞开的毛细槽228的其他形式或者机构。 Other examples include cusps (sharp point), the laser beam in the capillary grooves 228 formed in the knife 204, knife 204 or be removed from the material to produce other forms or bodies open capillary groove 228.当刀尖2¾被定位在皮肤内时，形成毛细槽2¾的任何技术都导致了自动的体液收集。 2¾ when the tip is positioned within the skin, the capillary grooves formed 2¾ any technique have led to the automatic collection of body fluids.此外，与封闭的毛细管相比，敞开的毛细管更容易收集位于切口周围的皮肤表面上的体液试样。 Further, as compared with closed capillary, open capillary easier to collect the body fluid sample on the surface of the skin around the incision.

[0049] 如图20中所示，基部206形状是圆形的。 [0049] As shown in FIG. 20, the base 206 is circular in shape.基部206可以在其他实施例中不同地成形，例如矩形、卵形或者方形。 Base 206 can be shaped differently in other embodiments, such as rectangular, oval or square.如下所描述，肋202、刀204和基部206可以从一块材料形成。 As described below, the ribs 202, 204 and knife 206 may be formed from a base material.在其他形式中，肋202和/或者刀OM可以单独地制造，然后附接到基部206。 In other forms, the ribs 202 and / or knife OM may be separately manufactured and then attached to the base 206.在一个实施例中，轮200被装载到构造成显示分析结果的计量器中。 In one embodiment, wheel 200 is loaded into a meter configured to display the analysis result.此外，在该实施例中，轮200是固定的，且基部206附接到计量器的壳体，使得计量器的壳体或者外部绕轮200旋转，以暴露未使用的刀204。 Further, in this embodiment, wheel 200 is fixed, and the base portion 206 is attached to the housing of the meter, so that the metering device or the external housing 200 is rotated about the wheel, to expose blade 204 unused.但是，在另一实施例中，基部206绕其中心旋转以暴露壳体中的未使用刀204。 However, in another embodiment, the base 206 is rotated to expose an unused blade housing 204 about its center.

[0050] 如图20、图21中所示，第一圆柱体208与刀204的腿部220相邻定位。 [0050] As shown in FIG 20, shown in Figure 21, a first cylinder 208 and the leg portion 220 positioned adjacent the blade 204.第一圆柱体208形状大体上是圆形的，并且在一个实施例中沿着刀204的腿部220朝向刀尖2¾滚动或者旋转，或者在另一实施例中，第一圆柱体208沿着腿部220的表面朝向刀尖2¾滑动。 The first cylinder 208 is substantially circular in shape, and in one embodiment 204 of the knife 220 along the leg portions toward the tip 2¾ scrolling or rotating, or in another embodiment, first cylinder 208 along the surface of the leg portion 220 toward the tip 2¾ slide.如所理解，第一圆柱体208将力施加到腿部220以沿着离开第一圆柱体208的方向移动刀204。 As appreciated, the first cylinder 208 to apply a force to the leg portion 220 in a direction away from the first cylinder 208 of the blade 204 moves.刀204通过第一圆柱体208的力的移动导致了刀尖2¾沿循着圆形路径来在用户中形成切口，如前所描述地。 Blade 204 by moving the first cylinder 208 results in a force along the tip 2¾ follow a circular path to form an incision in the user, as previously described.在第一圆柱体208的移动或者运动范围的结束处，第一圆柱体208反向且朝向基部206移动。 In the end of the first cylinder or the range of motion of the mobile 208, a first cylinder 208 to move toward the base 206 and the reverse.在其他实施例中，刀204的致动通过其他形式发生，例如驱动器、弹簧、或者另一机械或者电气机构。 In other embodiments, the knife 204 is actuated by the occurrence of other forms, such as drives, springs, or other mechanical or electrical means.对刀204的致动的这些其他形式将也迫使弯曲的刀尖2¾沿循圆形的运动。 These other forms of actuator blade 204 will be forced to follow a curved tip 2¾ circular motion.可以通过将第一圆柱体208沿着腿部220行进的距离、第一圆柱体208的直径和刀204的几何形状相互关联来跟踪刀尖226的切缝型式。 By the first leg portion 220 from the cylinder 208 to travel along the first cylinder 208 and the diameter of the blade geometry of the track 204 correlates tip 226 of slit type.

[0051 ] 在已经通过刀尖2¾形成切口之后，刀尖2¾通过弹回到其原始的切口形成前位置以及通过接触测试段210中的一个来将体液试样传输到测试段210从而从用户的皮肤移除。 [0051] After the incision has been formed by 2¾ tip, tip 2¾ by elastic forming position and back to its original incision by contacting a test section 210 of a body fluid sample to the test section 210 so that the user skin removed.当第一圆柱体208反向且朝向基部206移动时，刀尖226的曲率保证了：当刀尖2¾从切口缩回时，刀尖2¾将沿循其在切口期间所形成的相同的圆形路径。 When the first counter 208 and cylinder 206 moves toward the base, the curvature of tip 226 ensures that: when the tip is retracted from the incision 2¾, 2¾ tip will follow the same circle along which are formed during the cut- path.不必需要额外的致动器来将刀尖2¾从切口缩回，而是当第一圆柱体208返回到其原始位置时，刀204的弹性属性让刀尖2¾弹回到其由肋202所参考的原始位置。 Does not necessarily require an additional actuator to tip 2¾ retracted from the incision, but when the first cylinder 208 is returned to its original position, the resilient nature of the blade so that the cutting edge 204 springs back to its 2¾ referenced by the ribs 202 the original position.而且，当刀204弹回到其原始的切口形成前位置时，包含在毛细槽228中的体液试样在第二腿构件2M或者刀尖2¾接触测试段210时被传输到测试段210，如下所描述。 Further, when the blade 204 springs back to its original position before the incision is formed, comprising a body fluid sample in the capillary channel 228 is transmitted in the second leg member 2M or when the contact tip 2¾ test section 210 to the test section 210, the following Described.处在其原始位置中的刀204将保证随后的用户不会被污染的刀尖2¾意外地击中。 In its original position in the knife 204 will ensure that subsequent users will not be 2¾ accidentally hit the tip of contamination.

[0052] 在图21所示的实施例中，第二圆柱体212与第一圆柱体208相邻或者靠近定位， 以用作在第一圆柱体208的致动期间用于第一圆柱体208的止动机构。 [0052] In the embodiment illustrated in FIG. 21, the second cylinder 212 with first cylinder 208 is positioned adjacent to or near to serve during actuation of the first cylinder 208 of the cylinder 208 for the first stop mechanism.在所示的实施例中，第二圆柱体212形状大体上是圆形的，具有平坦表面230定位成接触腿部220。 In the embodiment shown, the second cylinder 212 is substantially circular in shape, having a planar surface 230 positioned to contact the leg portion 220.在其他实施例中，第二圆柱体12可以是另外的形状。 In other embodiments, the second cylinder 12 may be another shape.例如，第二圆柱体可以是矩形、三角形、或者卵形，如果要提及一些形状作为示例的话。 For example, the second cylinder may be rectangular, triangular, or oval, as if to mention some examples of the shape of words.第二圆柱体212形成了用于第一圆柱体208的止动件，以限制第一圆柱体208和刀204的运动。 The second cylinder 212 forms a stop for first cylinder 208 to limit movement of the first cylinder 208 and the knife 204.在另一实施例中，第二圆柱体212在刀204的致动以及刀尖2¾从切口缩回期间接触腿部220。 In another embodiment, the second leg portion 220 contacts the cylinder 212 and the actuator tip is retracted from the incision during 2¾ knife 204.例如，在致动期间，当第一圆柱体208也将力施加到腿部220时，第二圆柱体212将力施加到腿部220。 For example, during actuation, a first cylinder 208 when a force is applied to the leg portion 220, the second cylinder 212 to apply a force to the leg portion 220.在该实施例中，第二圆柱体212和腿部220之间的接合保证了刀尖2¾从形成在用户的皮肤中的切口中缓慢地抽出。 In this embodiment, the engagement between the cylinder 212 and a second leg portion 220 to ensure that the tip is slowly withdrawn from a 2¾ slit is formed in the skin of the user.在将刀尖2¾从切口移除以及刀尖2¾运动到其原始位置期间，第二圆柱体212控制刀尖226的速度。 In the nose and removed from the incision during the movement 2¾ 2¾ tip to its original position, the second cylinder 212 controls the speed of the tip 226.第一圆柱体208和第二圆柱体212的组合保证了刀尖2¾将沿循特别规定的切缝和速度型式。 Combination of the first cylinder 208 and second cylinder 212 ensures that the slit type of special provisions and the speed of the cutting edge to follow a 2¾.在一个实施例中，第一圆柱体208和第二圆柱体212的组合保证了刀尖2¾迅速地形成切口且刀尖2¾从切口缓慢地缩回。 In one embodiment, the combination of the first cylinder 208 and second cylinder 212 ensures that the tip 2¾ rapidly an incision tip and retracted from the incision 2¾ slowly.在另一实施例中，第一圆柱体208在没有第二圆柱体212的情况下控制刀尖226的速度。 In another embodiment, the tip speed of the first cylinder 208 226 in the absence of the second cylinder 212 of the control.

[0053] 在一个实施例中，微取样器轮200由单件材料通过冲压金属板来形成多个肋202 和多个微针或者刀204并且移除任何多余的材料而形成。 [0053] In one embodiment, the micro-sampler wheel 200 from a single piece material and a plurality of ribs 202 a plurality of micro-needle or blade 204 is formed by stamping a metal plate and is formed to remove any excess material.在另一实施例中，微取样器轮200 通过蚀刻或者弯曲金属板来形成多个肋202和多个微针或者刀204而形成。 In another embodiment, the wheel 200 micro-sampler 202 and a plurality of micro-needles or a knife to form a plurality of ribs 204 are formed by etching or bending a metal plate.在其他实施例中，微取样器轮200可以通过将多个肋202和多个刀204附接到基部206而形成。 In other embodiments, the micro-sampler 200 may be formed by a plurality of wheels 202 and a plurality of ribs 204 attached to the base blade 206 is formed.微取样器轮200可以由金属制造，例如不锈钢、钛、或者镍、塑料和/或者其他材料。 Microsampler wheel 200 may be manufactured from a metal, such as stainless steel, titanium, or nickel, a plastic, and / or other materials.

[0054] 多个测试段210与如上所述的测试段观相似，此后为了简洁的目的，细节将不再重复。 [0054] The plurality of test sections 210 as described above and the concept is similar to the test section, then for purposes of brevity, the details will not be repeated.多个测试段210靠近多个刀204定位，使得一个测试段210靠近每个毛细槽2¾定位。 A plurality of test sections 210 near the plurality of blade 204 is positioned, such that a test section 210 is positioned adjacent each capillary groove 2¾.多个测试段210可以定位成靠近第二腿构件224(如图22中所示)、在刀尖2¾前面(如图M中所示)、或者刀尖226的后面(如图沈中所示)。 A plurality of test sections 210 may be positioned close to the second leg member 224 shown in (shown in FIG. 22), in front of 2¾ tip (as shown in FIG. M), or behind the tip 226 (as shown in Shen ).

[0055] 现在将参照刀204和测试段210的各种构造。 [0055] Referring now to the knife 204 and the test section 210 of various configurations.如图22中所示，测试段210靠近第二腿构件2M定位以分析体液试样。 As shown in FIG. 22, the test section 210 is positioned close to the second leg member 2M to analyze body fluid sample.在该实施例中，毛细槽2¾定位在刀204的前侧上，如图23中所示。 In this embodiment, the capillary groove 2¾ positioned on the front side of the knife 204, shown in Figure 23.为了形成切口，第一圆柱体208沿着腿部220旋转且将力施加到腿部220， 以便绕基部206的边缘旋转刀204。 To form the notch, a first cylinder 208 and the force is applied to the leg portion 220 along the leg 220 is rotated so as to rotate about a knife edge 204 of the base 206.在如图22中所示的实施例中，第二圆柱体212将力施加到腿部220以协助第一圆柱体208绕基部206的边缘旋转腿部220。 In the embodiment shown in FIG. 22, the second cylinder 212 applies a force to the first leg portion 220 to assist in cylinder 208 rotates about the leg edge 220 of the base 206.如所理解，第二圆柱体212是可任选的。 As will be appreciated, the second cylinder 212 is optional.当腿部220绕基部206的边缘旋转时，刀尖2¾沿循着圆形路径来在用户中形成切口。 When the leg portion 220 is rotated about the edge of the base 206, 2¾ tip along a circular path to follow an incision in the user.当刀尖2¾形成切口时，毛细槽228收集体液试样。 When the notch is formed 2¾ tip, the capillary channel 228 to collect a body fluid sample.毛细槽228中的体液试样首先在大体上平行于皮肤中的切口的方向上流入刀尖226中。 Groove 228 in the body fluid sample in the capillary tip 226 first flows in a direction substantially parallel to the skin incision.在该实施例中，体液试样继续流入第二腿构件224的毛细管228中。 In this embodiment, the body fluid sample continues to flow into the capillary 228 in the second leg member 224.当体液试样流入第二腿构件224中时， 流动的方向改变了第三角度Y。 When the body fluid sample into the second leg member 224, changing the direction of flow of the third angle Y.在一种形式中，第三角度Ύ大致是90度，因此体液试样的流动从刀尖2¾到第二腿构件2¾将方向改变了90度。 In one form, the third angle is substantially 90 degrees Ύ, thus the flow of body fluid sample 2¾ a direction change by 90 degrees from the cutting edge to the second leg member 2¾.第一圆柱体208和第二圆柱体212反向，使得力从腿部220移除并且刀尖2¾从皮肤缩回。 The first cylinder 208 and second cylinder 212 is reversed, so that the retraction force is removed from the leg portion 220 and 2¾ tip from the skin.当第一圆柱体208和第二圆柱体212反向时，刀204弹回或者移动通过刀204的原始的切口形成前位置，使得第二腿构件224接触测试段210。 When the first cylinder 208 and second cylinder 212 is reversed, spring back or moving blade 204 is formed from the original position before the incision knife 204, 224 such that the second leg member 210 in contact with the test section.当第二腿构件2M接触测试段210时，体液试样从毛细槽2¾传输到测试段210。 2M second leg member when contacted with the test section 210, the body fluid sample from the capillary channel to the test section 210 2¾.在该实施例中，毛细槽2¾延伸到第二腿构件224中对应的距离，使得当第二腿构件2M接触测试段210时，毛细槽228中的体液试样被传输到测试段210中。 In this embodiment, the capillary groove extending 2¾ distance to the second leg member 224 corresponding to the second leg member such that when contacted with the test section 210 2M, the body fluid sample in the capillary grooves 228 are transmitted into the test section 210.测试段210分析该体液试样。 Test section 210 analyzes the body fluid sample.

[0056] 如图24、图25中所示，毛细槽2¾被定位在刀尖226的前侧上，并且同样地，测试段210被定位成靠近刀尖2¾的前侧。 [0056] 24, as shown in FIG. 25, 2¾ capillary grooves are positioned on the front side of the tip 226, and similarly, the test section 210 is positioned near the front side of the tip 2¾.第一圆柱体208、第二圆柱体212以及刀204与参照图22、图23描述的实施例相似，除非在此有不同的描述。 A first cylinder 208, second cylinder 212 and the blade 204 with reference to FIG. 22, FIG. 23 similar to the embodiment described herein, unless described differently.刀尖2¾被致动以在皮肤中形成切口，毛细槽2¾从切口收集体液试样。 2¾ tip is actuated to form an incision in the skin, capillary groove 2¾ collected body fluid sample from the incision.在该实施例中，体液试样在毛细槽228中沿着大体上平行于皮肤中的切口的方向流动。 In this embodiment, the body fluid sample in the capillary grooves 228 in a direction parallel to the incision in the skin along substantially flow.当刀尖2¾从皮肤中的切口缩回之后，刀204移动到其原始的切口形成前位置，并且刀尖2¾接触测试段210。 When the tip 2¾ retracted from the incision in the skin, the knife 204 is moved to its original position before the incision is formed, and a contact tip 210 2¾ test section.当刀尖2¾接触测试段210时， 来自毛细槽228的体液试样沉积在测试段210上。 When the contact tip 2¾ test section 210, a body fluid sample from the capillary grooves 228 on the test segment 210 is deposited.

[0057] 在另一实施例中，如图沈和图27所示，毛细槽2¾位于刀尖226的后侧或者背侧上。 [0057] In another embodiment, as shown in Figure sink and, 2¾ capillary groove located on the rear side of the cutting edge 226 or the back side 27.如图所示，刀尖2¾可以包括从刀尖226的后侧上的毛细管槽2¾延伸通过刀尖2¾ 至刀尖226的前侧的第二毛细槽229。 As shown, the tip may include a 2¾ 2¾ capillary grooves extending from the tip 226 on the back side of the second capillary groove by the front tip 226 of the nose to 2¾ 229.利用该额外的毛细槽229，测试段210可以定位成与刀尖2¾的后侧相邻或者与其前侧相邻。 With this additional capillary groove 229, the test section 210 may be positioned adjacent to the rear side of the nose adjacent its 2¾ or front side.第一圆柱体208、第二圆柱体212和刀204与参照图22、图23所描述的实施例相似，除非在此有不同的描述。 A first cylinder 208, second cylinder 212 and the tool 204 described with reference to FIG. 22, FIG. 23 is similar to the embodiments described, unless differently described herein.刀尖2¾在皮肤中形成切口，并且毛细槽2¾从该切口收集体液试样。 2¾ tip forming an incision in the skin and collecting a body fluid sample capillary groove 2¾ from the incision.在该实施例中，体液试样沿着大体上平行于皮肤中的切口的方向在毛细槽228中流动。 In this embodiment, the body fluid sample 228 along generally parallel to the direction of flow in capillary grooves cut in the skin.在一个实施例中，随着刀尖2¾返回到其原始切口形成前位置，刀尖226的后侧接触与刀尖226的后侧相邻定位的测试段210，且毛细槽228中的体液试样被沉积到测试段210上。 In one embodiment, as the tip 2¾ returned to its original position before the notch is formed, the rear tip in contact with the rear side 226 of tip 226 is positioned adjacent to the test section 210, and the fluid sample in the capillary grooves 228 the test sample is deposited on the segment 210.如所理解，毛细槽229的存在保证了体液试样将沉积到测试段210上，不管毛细槽2¾是位于刀尖226的前侧上还是后侧上，也不管测试段210 被定位成相邻于刀尖226的后侧还是前侧。 As will be appreciated, the presence of the capillary grooves 229 ensures that the body fluid sample is deposited onto the test section 210, regardless of the capillary groove 2¾ is located on the front side or the rear side of the tip 226, regardless of the test section 210 is positioned adjacent tip 226 to the rear side or front side.

[0058] 第三实施例也涉及与上述第二实施例相似的集成的一次性盒或者盘。 [0058] The third embodiment also relates to the above-described second embodiment, similar to the integrated disposable cartridge or disk.该第三实施例中的盒也利用独特的刀轮设计，该刀轮设计包括与多个肋交替的多个微针或者刀。 The cartridge of the third embodiment also utilizes a unique embodiment of the cutter wheel design, the design comprising a cutter wheel and a plurality of alternating ribs plurality of micro-needle or blade.该实施例中的刀与前述实施例中的刀相似。 Examples knife blade of this embodiment is similar to the previous embodiment.刀和多个肋以交替的方式附接到基部，并且构造在初始的切口形成前位置中。 Alternating knives and a plurality of ribs attached to the base and configured to form a front position in the initial incision.刀和多个肋被构造成绕基部旋转。 Knives and a plurality of ribs are configured to rotate about the base.当第一驱动机构压靠着刀和与该刀相邻的一个或多个肋时，在穿刺和缩回期间第一驱动机构迫使刀尖绕基部旋转。 When the first driving mechanism is pressed against the knife blade and an adjacent one or more ribs, the first puncturing and retraction force drive means during rotation of the base about the cutting edge.第二驱动机构对与刀紧邻的一个或多个肋施力，以便当肋绕基部旋转时接触切口位置附近的皮肤，且由此形成这样的参考平面，其中刀的穿刺深度从所述参考平面相对于相邻的一个或多个肋进行测量。 Second driving means for the knife and the immediately adjacent one or more ribs is biased so as to contact the base when the rotation of the skin around the ribs near the incision site, and thereby forming such a reference plane, wherein the blade penetration depth from the reference plane with respect to the one or more ribs adjacent measurements.一个或多个肋相对于刀的位置允许用户独立于刀的致动和运动来调节刀的穿刺深度。 One or more ribs with respect to the position of the knife blade to allow the user independent actuation and movement of the blade to adjust the penetration depth.例如，刀的致动和运动是通过将第一驱动机构压靠着一个或多个肋以及所述刀而确定，而所述穿刺深度则是通过将第二驱动机构压靠着一个或多个肋而确定所述穿刺深度。 For example, blade actuation and movement is determined by the first driving mechanism is pressed against one or more ribs and the knives, and by the puncturing depth is the second drive mechanism is pressed against one or more determining the penetration depth of ribs.当一个或多个肋的取向随着第二驱动机构的确定而改变时，刀的穿刺深度很容易调节。 When one or more ribs with determining the orientation of the second driving means is changed, the blade penetration depth is easily adjustable.此外，当第二驱动机构压靠和释放一个或多个肋以相对于皮肤产生肋的泵送作用时， 第二驱动机构的独特和雅致形状使得一个或多个肋将额外的体液传输到皮肤。 Further, when the second driving mechanism is pressed against the ribs and releasing one or more pumping action with respect to the skin of the ribs, elegant and unique shape of the second driving means such that one or more additional ribs fluid transfer to the skin .

[0059] 根据另一实施例的微取样器轮300显示在图观、图四、图30、图31和图32中。 [0059] In FIG concept, Figure IV, Figure 30, microsampler wheel according to another embodiment of the display 300 in FIG. 31 and FIG. 32.微取样器轮300与微取样器轮200相似，因此为了简洁的目的，与微取样器轮300相似的微取样器轮200中的特征将不再讨论。 Microsampler wheel 200 is similar to the micro sampler wheel 300, so for brevity, the micro-features 200 and 300 similar to the sampler wheel microsampler wheel will not be discussed.与微取样器轮200相似，微取样器轮300包括与多个刀304交替的多个肋302。 Similar microsampler wheel 200, wheel 300 includes a micro-sampler 304 and a plurality of alternating blade plurality of ribs 302.也与微取样器轮200相似，微取样器轮300包括多个肋302和多个刀304从其延伸的基部306。 Microsampler also similar to wheel 200, microsampler wheel 300 includes a plurality of ribs 302 and the base 304 a plurality of knives 306 extending therefrom.多个肋302的每个包括附接到基部306的第一端330和构造成接触用户的皮肤S的第二端332。 Each of the plurality of ribs attached to the base 306 includes a first end 330 and configured to contact the user's skin S 302 the second end 332.在该实施例中，在特定的刀304的致动之前，与该刀相邻的一对肋302大体上平行于刀304的腿部320。 In this embodiment, before a specific knife 304 is actuated, the blade adjacent pair of ribs 302 is substantially parallel to the leg portion 320 of the knife 304.微取样器轮300也包括第一圆柱体308 和第二圆柱体312。 Microsampler wheel 300 also includes a first cylinder 308 and second cylinder 312.第一圆柱体308与第一圆柱体208相似地构造。 The first cylinder 308 is configured similarly to the first cylinder 208.第二圆柱体312包括一对圆柱体或者辊子，所述一对圆柱体或者辊子被定位成使得每个辊子接触单独的肋302。 The second cylinder 312 includes a pair of cylinders or rollers, the pair of cylinders or rollers are positioned such that each roller 302 contacts the individual ribs.第二圆柱体312的辊子横跨位于它们之间的一个刀304，使得第二圆柱体312的单独的辊子被定位成避免与刀304接触。 A second cylindrical roller 312 is positioned across a knife 304 between them, so that the rollers separate second cylinder 312 is positioned to avoid contact with the knife 304.在该实施例中，第二圆柱体312的单独的辊子中的每个包括弯曲部分314和大体上平坦的部分316。 In this embodiment, a separate second cylinder rollers 312 each includes a curved portion 314 and a generally planar portion 316.在其他实施例中，第二圆柱体312可以是另外的形状。 In other embodiments, the second cylinder 312 may be another shape.尽管未显示，但在一些实施例中，微取样器轮300也包括如前所述的多个测试段。 Although not shown, in some embodiments, microsampler wheel 300 also includes a plurality of test sections as previously described.

[0060] 如图观中所示，刀304中的一个的刀尖3¾也定位成与用户的皮肤S相邻或者与其接触。 [0060] As shown in FIG concept, one of 3¾ blade tip 304 is also positioned adjacent to the user's skin S, or contact therewith.在所示的实施例中，挤出环（expression ring) 400被定位在指尖上，但是在其他实施例中，对微取样器轮300形成切口、挤出体液试样和收集体液试样而言，挤出环400不是必需的。 In the embodiment shown, the extrusion ring (expression ring) 400 is positioned on the fingertip, in other embodiments, micro-incision sampler wheel 300 is formed, and an extrusion body fluid sample while the collected body fluid sample Yan, extrusion ring 400 is not necessary.此外，微取样器轮300被构造成用于除了手指之外的用户的其他身体部位上，换言之，微取样器轮300被构造成用于替代性部位的测试。 Further, microsampler wheel 300 is configured for other body parts in addition to a finger of the user, in other words, microsampler wheel 300 is configured for alternate site testing.在该初始的开始位置中，第二圆柱体312的大体上平坦的部分316接触一对肋302。 In the initial start position, the second cylinder 312 is a substantially flat portion 316 contacts the pair of ribs 302.在该实施例中，一对肋302大体上平行于定位在它们之间的刀304的腿部320。 In this embodiment, the pair of ribs is substantially parallel to the leg portion 302 positioned therebetween knife 304 320.在其他实施例中，一对肋302可以被定位在刀304 上方或者下面。 In other embodiments, the pair of ribs 302 may be located above or below the cutter 304.

[0061] 如图四中所示，旋转第二圆柱体312，使得第二圆柱体312的弯曲部分314接触一对肋302的每个的第二端332，并且将其压靠于用户的皮肤S。 [0061] As shown in FIG. Fourth, the rotation of the second cylinder 312, so that the second cylindrical portion 314 of each of the curved second end 332 of the contact 302 of the pair of ribs 312, and which is pressed against the user's skin S.弯曲部分314关于肋302的取向便利于第二圆柱体312的旋转，以由此在切缝、挤出和取样期间调节肋302的取向。 Curved portion 314 on alignment ribs 302 to facilitate the rotation of the second cylinder 312 to thereby cut seam, and adjusting the orientation of the ribs 302 sampling during extrusion.一对肋302和用户的皮肤S之间的初始接触是可以从其测量刀尖3¾的穿刺深度的皮肤参考位置。 Initial contact between the ribs 302 and the user's skin S is one pair from the reference position for measuring skin penetration depth of the tip of 3¾.在一些实施例中，第二圆柱体312被旋转以进一步将一对肋302压靠在用户的皮肤S，以将体液挤出到切口部位。 In some embodiments, the second cylinder 312 is further rotated to the pair of ribs 302 is pressed against the user's skin S, the body fluid to be extruded into the incision site.在其他实施例中，第二圆柱体312前后旋转，从而导致一对肋302相对于用户的皮肤S的泵送作用，以进一步方便将体液挤出到切口部位。 In other embodiments, the second cylinder 312 rotates back and forth, resulting in a pair of ribs 302 with respect to the pumping action of the user's skin S, the body fluid to further facilitate extruded into the incision site.

[0062] 如图30中所示，刀304被致动以在皮肤中形成切口。 [0062] As shown in FIG. 30, the knife 304 is actuated to form an incision in the skin.第一圆柱体压靠着一对肋302和刀304的腿部320，以便绕基部306旋转刀304并且迫使刀尖3¾进入用户的皮肤S。 A first pair of ribs is pressed against the cylindrical body 302 and leg portions 320 of the blade 304 to about 306 and the base 304 forces the rotating blade tip into the user's skin S. 3¾刀尖326的穿刺深度通过刀304的几何形状、靠着用户的皮肤S的一对肋302的取向、以及第一圆柱体308沿着一对肋302行进的距离和/或者直到第一圆柱体308接触第二圆柱体312来确定。 And / or from the cylinder until the first penetration depth 326 of the tip by the geometry of the knife 304, the alignment rib 302 against a user's skin S, and the first cylinder 308 along a pair of ribs 302 travels 308 contacts second cylinder 312 is determined.在该形式中，当第一圆柱体308沿着一对肋302和腿部320滚动时，刀尖3¾ 绕基部306旋转以在皮肤S中形成切口。 In this form, when the cylinder 308 rolls along the first pair of ribs 302 and leg portions 320, 306 of the base rotating about 3¾ tip to form an incision in the skin S.当第一圆柱体308接触第二圆柱体312时，停止刀尖3¾在皮肤S中的穿刺。 When the first cylinder 308 in contact with the second cylinder 312 is stopped when the piercing tip in the skin S of 3¾.在另一实施例中，第一圆柱体308只沿着刀304的腿部320滚动，以绕基部306旋转刀304并对刀尖3¾施力使其进入用户的皮肤S。 In another embodiment, the first cylinder 308 to roll along the leg 304 of the blade 320 to about 306 and the base 304 of the rotating blade tip 3¾ urging it into the user's skin S.在再一实施例中， 第一圆柱体308被构造成压靠与腿部320相邻的一对肋302，或者构造成沿着与腿部320相邻的一对肋302滚动。 In another embodiment, first cylinder 308 is configured to press against the leg portions 320 of the adjacent pair of ribs 302, or configured to roll along the leg 320 adjacent pair of ribs 302.在任一实施例中，当刀304绕基部306旋转时，刀尖3¾沿循圆形路径在用户的皮肤S中形成切口。 In either embodiment, the base portion 306 when the knife 304 rotates about 3¾ tip along an incision in the skin S of the user in a circular path.

[0063] 如图31中所示，刀304与上述刀204相似地收集体液试样。 As shown in FIG. 31 [0063], the knife 304,204 similarly collected body fluid sample with the cutter.但是，一对肋302的每个的第二端332压靠着皮肤S。 However, the second end 332 of each of the pair of ribs 302 is pressed against the skin S.如前所述，在另一实施例中，第二圆柱体312前后旋转，以便导致靠着用户的皮肤S的一对肋302的泵送作用。 As described above, in another embodiment, before and after the rotation of the second cylinder 312, so as to cause the pumping action of the pair of ribs 302 against the skin S of the user.该泵送作用方便将体液挤出到切口部位，从而方便在刀304中对体液的采样。 The extruded body fluid pumping action to facilitate the incision site, thereby facilitating the sampling of body fluids in the tool 304.

[0064] 第一圆柱体308开始从第二圆柱体312移动或者滚回到其初始开始位置，如图32 中所示。 [0064] The first cylinder 308 from the second roller or cylinder 312 moves back to its initial starting position, as shown in FIG 32.当第一圆柱体304返回到其原始位置时，刀304绕基部306旋转并弹回到其切口形成前位置。 When the first cylinder 304 to return to its original position, the lancet 304 about the rotation base 306 and springs back to its slit forming position.由于第二圆柱体312由分开一定距离的两个辊子或者构件构造，所以刀304 弹回且行进通过两个辊子或者构件之间所形成的间隙。 Since the second cylinder 312 separated by a distance of two rollers or member configured, so blade 304 springs back and travels through the gap formed between two rollers or members.如前所提及和上面所描述的那样， 刀304接触测试段以将体液试样传输到测试段，与刀204相似。 As previously mentioned and as described above, blade 304 contacting the body fluid test section to transfer sample to the test section, similar to the knife 204.第二圆柱体312被旋转，使得弯曲部分314从一对肋302脱离接合，从而一对肋302绕基部306朝向其初始的切口形成前位置旋转。 The second cylinder 312 is rotated, so that the curved portion 314 is disengaged from the pair of ribs 302, so that the pair of ribs 302 around the base 306 toward its initial position before the rotation notch is formed.尽管未示出，但是第二圆柱体312将继续旋转到其原始的切口形成前位置， 直到大体上平坦的部分316接触所述一对肋302。 Although not shown, but will continue to rotate the second cylinder 312 to its original position before the incision is formed, until it contacts a substantially flat portion 316 of the pair of ribs 302.

[0065] 根据一个实施例的盒420显示在图33、图34、图35、图36、图37、图38、图39和图40中。 In [0065] accordance with one embodiment of the cartridge 420 shown in FIG 33, FIG 34, FIG 35, FIG 36, FIG 37, FIG 38, FIG 39 and FIG 40.正如从这些图中所认识到的那样，盒420与图1、图2、图3、图4、图5、图6和图7中所显示的盒20共享了许多相同的特征。 As appreciated from the above figures, the cartridge 420 of FIG. 1, 2, 3, 4, 5, 6 and 7 the cartridge shown in FIG. 20 share many of the same features.因此，为了简洁，盒420中和盒20共同的特征将不再讨论。 Thus, for brevity, the cartridge 420 and the cartridge 20 common features will not be discussed.盒420具有测试环框架480 ；但是，盒20不具有测试环框架。 Cartridge ring 420 having a frame 480 test; however, the cartridge 20 has not tested the ring frame.与盒20相似，盒420 具有测试环426 ；但是，测试环4¾被安装到测试环框架480，如下面将更详细描述地。 20 is similar to the cartridge, the test cartridge 420 has a ring 426; however, the ring test test ring 4¾ is mounted to frame 480, as described in more detail below.也与盒20相似的是，盒420包括定位在刀框架430中的刀轮422。 20 is also similar to the cartridge, the cartridge 420 includes a frame 430 positioned in the tool in the cutter wheel 422.但是，刀轮422和刀框架430 分别与刀轮22和框架30稍微不同。 However, the cutter wheel 422 and frame 430 respectively cutter blade wheel 22 and the frame 30 is slightly different.在一个实施例中，盒20包括25个刀M、25个测试段28和25个室32。 In one embodiment, the cartridge 20 comprises a blade 25 M, 25 test sections 28 and 25 chambers 32.相比较而言，在一个实施例中，盒420包括50个刀424、50个测试段似8 和50个室432，其中，盒420具有比盒20大致大20%的直径。 In comparison, in one embodiment, the cartridge 420 comprises a blade 50 424,50 test sections like chambers 8 and 50 432, wherein the cartridge 420 has a substantially 20% larger than the diameter of the cartridge 20.

[0066] 盒420将体液试样从刀4¾传输到测试段428的方式与盒20不同。 [0066] The cartridge 420 from the body fluid sample to 4¾ knife embodiment 428 of the test section and the cartridge 20 are different.如下所解释地，盒420包括具有刀尖446的刀424，所述刀尖446在组织中形成切口，将来自切口的体液试样收集在毛细槽448中，以及当刀尖446接触测试段428时将体液试样传输到测试段428。 As explained below, the cartridge 420 comprises a blade 446 having a tip 424, the tip 446 forming an incision in tissue, a body fluid sample collected from an incision in the capillary grooves 448, and when the contact tip 446 test section 428 when the body fluid sample to the test section 428.换言之，刀尖446将体液试样传输到测试段428。 In other words, the tip 446 a body fluid sample to the test section 428.如所理解，体液试样不需要填充刀424的整个毛细槽448，以具有用来测试的足够大小的试样。 As will be appreciated, the knife body fluid sample need not fill the entire capillary grooves 424 448, to have a sufficient size for the sample tested.此外，由于体液试样不需要填充整个毛细槽448，所以实现了更高的测试成功率，以及需要用更小尺寸的体液试样来进行测试。 Further, since the body fluid sample need not fill the entire capillary groove 448, so to achieve a higher success rate testing, and the need to test a bodily fluid sample of smaller size.如前所述，盒20包括刀对，刀M具有刀尖46，刀尖46形成切口，体液试样收集在毛细槽48中，且当刀返回到其原始位置时，接触部分44接触测试段观以将体液试样传输到测试段观。 As described above, the cartridge 20 includes a blade pair having a blade tip 46 M, form an incision tip 46, a body fluid sample collected in capillary groove 48, and when the knife returns to its original position, the contact portion 44 in contact with the test section View to body fluid sample to the test section concept.在该构造中，接触部分44或者刀M的尾部将体液试样传输到测试段观。 In this configuration, the contact knife 44 or the tail portion M are transferred to the test body fluid sample View segment.

[0067] 与盒20相似，盒420包括如图33中所示的第一无菌片438。 [0067] Similar to the cartridge 20, the cartridge 420 includes a first sterility sheet shown in FIG. 33 438.当组装盒420时，第一无菌片438被定位成覆盖和密封测试环框架480的多个测试器开口482的一侧。 When assembled cassette 420, a first sterile sheet 438 is positioned to cover and seal the plurality of test test ring frame 480 of the opening 482 side.如上所述，盒420包括测试环框架480。 As described above, the cartridge 420 includes a frame 480 test ring.测试环框架480包括多个测试器开口482。 Ring test test frame 480 includes a plurality of openings 482.每个测试器开口482的尺寸设定成接纳刀尖446。 Each tester size of the opening 482 of tip 446 is set to receive.测试环框架480也包括多个窗口484和多个框架壁485，其中每个窗口484被定位在一对框架壁485之间。 Test ring frame 480 also includes a plurality of windows 484 and 485 a plurality of frame walls, wherein each window 484 is positioned between a pair of frame walls 485.当组装测试环框架480和刀框架430时，每个内窗口484被定位在刀框架430的一对刀壁434之间。 When assembled test ring frame 480 and the knife frame 430, each window 484 is positioned within the cutter frame 430 between a wall 434 on the knife.窗口484与测试段428紧邻的放置使得定位在盒420中心的光学装置或者其他装置能够通过窗口484中的一个观察到对应的测试段428。 Window test sections 428 and 484 immediately placed such that the optical device, or other device is positioned at the center of the cartridge 420 can be observed in the corresponding test section 428 through a window 484 a.在一个实施例中，接合机构可以接合框架壁485中的一个并旋转盒420，以将刀框架430中随后的室432和对应的测试器开口482定位成与驱动器436 对齐。 In one embodiment, the engagement mechanism may engage a wall of the frame 485 and rotates the cartridge 420 to the chamber 430 in the subsequent blade frame 432 and a corresponding opening 482 positioned to test driver 436 is aligned with.多个内窗口484的每个的形状是矩形的，但是窗口484可以在其他实施例中不同地构造。 Shape of each of the plurality of window 484 is rectangular, but the window 484 may be configured differently in other embodiments.多个内窗口484和多个框架壁485被定位成接纳测试环426。 A plurality of walls 484 and a plurality of window frame 485 is positioned to receive a test ring 426.

[0068] 测试环4¾包括限定了多个测试段428的多个分度线，如图34中所示。 [0068] 4¾ test loop comprising a plurality of reticle defining a plurality of test sections 428, as shown in Figure 34.测试环426附接到多个内窗口484和测试环框架480的多个框架壁485，使得每个分度线4¾与每个刀壁434对齐。 Ring 426 attached to a plurality of test windows within the plurality of frame walls 484 and 480 of the test ring frame 485, such that each of the reticle 434 is aligned with each blade 4¾ wall.此外，每个测试段似8定位在刀框架430的室432中的一个内，使得对应的窗口484与多个刀424中的一个对齐。 Further, each of the test sections like 8 is positioned in a chamber 432 within the cutter frame 430, such that the corresponding window 484 in alignment with a plurality of knives 424.

[0069] 如图33和图37中所示，刀轮422包括刀缘423，多个刀似4从刀缘423径向向内延伸。 As shown in [0069] 33 and 37, cutter wheel 422 includes a knife edge 423, a plurality of blade like a knife edge 4 extending radially inwardly from 423.每个刀4M包括柔韧性的腿部442、接触部分444和刀尖446。 Each blade comprises a 4M flexible legs 442, 444 and contact portion 446 tip.每个刀4M的接触部分444是弯曲的，并且尺寸设定成在刀似4处于歇置时歇置在刀框架430的多个壁架492中的一个上。 The contact portion 444 of each blade is curved 4M, and sized to rest on the knife-like 4 placed on the knife frame 492 a plurality of ledges 430 when in the rest position.此外，在该歇置位置中，刀尖446没有接触测试段428。 Further, in the rest position is set, there is no contact tip 446 test section 428.进一步地，当致动刀424 时，刀尖446配合在测试器开口482中，如下所述。 Further, when the knife actuator 424, the tip 446 with an opening 482 in the test device, as described below.每个刀似4也限定槽447，槽447的尺寸设定成接纳驱动器436的尖端438，如下更为详细地描述地。 Each blade groove 447 also defines like 4, the dimension of the slot 447 sized to receive the drive tip 438 436, as described in more detail.刀尖446限定毛细槽448。 Tip 446 defines a capillary groove 448.此外，在已经致动刀似4且处于最终的位置中之后，刀尖446靠着测试段4¾歇置，使得体液试样从毛细槽448传输到测试段428。 In addition, after 4 and has been activated tool like in the final position, the tip 446 against the test section 4¾ rest position, so that the body fluid sample from the capillary groove 448 to the test section 428.

[0070] 图33、图35和图36中的刀框架430构造成与如图1、图2中所示的框架30稍微不同。 [0070] FIG. 33, FIG. 35 and FIG blade frame and configured to 36430 in FIG. 1, the frame 30 shown in Figure 2 is slightly different.图33中的刀框架430包括限定多个室432的多个壁434。 Knife frame 33 defining a plurality of chambers 430 includes a plurality of walls 432 to 434.刀框架430包括边缘436， 所述边缘436的尺寸设定成接纳多个框架壁485以在刀框架430上定位测试环框架480。 Frame 430 includes a knife edge 436, the size of the edge 436 is sized to receive a plurality of frame walls 485 to 430 is positioned on the test ring frame 480 in the knife frame.刀框架430也包括多个壁架492。 Knife frame 430 also includes a plurality of ledges 492.每个壁架492的尺寸设定成接纳刀424的接触部分444。 The size of each ledge 492 is sized to receive the contact portion 444 of blade 424.壁架492的一个被定位在多个室432中的每个内。 A ledge 492 is positioned in each of the plurality of chambers 432.在所示的实施例中，多个壁架492中的每个大体上是平坦的。 In the embodiment shown, the ledges 492 in each of the plurality of substantially planar.多个开口494被定位在多个壁434和多个壁架492之间。 A plurality of openings 494 are positioned between a plurality of walls 434 and 492 a plurality of ledges.每个开口494的尺寸设定成接纳驱动器436。 Each size of the opening 494 is sized to receive drive 436.如图37、图38、图39和图40中所示，驱动器436包括锐端或尖端438以穿透放置在开口494之上的第二无菌片440，如下所描述。 37, 38, and 39 shown in FIG, 40, the drive 436 includes a sharp or pointed end 438 penetrates the opening 494 is placed over the second sterile sheet 440, as described below.尖端438进入刀424的槽447以致动刀424，如下所述。 438 into the tip 424 of the knife blade 424 such that the groove 447, as described below.

[0071] 如图33中所示，盒420包括定位成覆盖和密封刀框架430的多个室432的第二无菌片440。 [0071] As shown in FIG 33 includes a STB 420 positioned to cover and seal the plurality of lancet frame 430 second sterile chamber 440 of sheet 432.第一无菌片438、测试环4¾和第二无菌片440被构造成覆盖和密封多个测试器开口482、多个室432和多个内窗口484以形成气密的盒420。 The first sterility sheet 438, and a second sterile test ring 4¾ sheet 440 is configured to cover and seal the plurality of test openings 482, a plurality of chambers 432 and a plurality of windows 484 within cartridge 420 to form an air-tight.相似地，盒20的第一无菌片38、测试环沈和无菌片40构造成形成气密的盒20。 Similarly, the first cartridge 20 of sterility sheet 38, the test ring 40 is configured sink and the sterility sheet 20 to form a gas-tight box.

[0072] 为了使用盒420，用户在多个测试器开口482中的当前起作用的一个之上定位将被切缝的身体部位，最可能是手指。 [0072] To use the cartridge 420, the plurality of user tester 482 acting on a current opening of the body part to be positioned in the slit, most likely a finger.驱动器436被致动以穿透第二无菌片440、通过对应的开口494且进入室432。 Driver 436 is actuated to penetrate the second sterile sheet 440, through the corresponding opening 494 and into chamber 432.驱动器436继续移动到室432中，且驱动器436的尖端438接合起作用的刀424的槽447。 Driver 436 continues to move into the chamber 432, the tip 436 and the driver 438 engaging knife 424 acting groove 447.当驱动器436接合槽447时，驱动器436将力施加到腿部442以沿着垂直于框架430的方向移动刀尖446。 When the driver 436 engaging grooves 447, driver 436 applies force to the leg 442 to move in a direction perpendicular to the frame 430 along the nose 446.随着刀尖446移动，刀尖446穿透第一无菌片438并继续进入到用户的皮肤内，所述用户的皮肤已经被放置在起作用的测试器开口482 之上。 With the movement of tip 446, tip 446 penetrates the first sterility sheet 438 and continues into the user's skin, the skin of the user function has been placed over the opening 482 of the tester.在一个实施例中，当刀尖446形成切口时，来自切口的体液试样通过毛细作用沿着毛细槽448朝向接触部分444行进，从而毛细槽448在刀尖446位于用户的皮肤中时从切口收集体液试样。 In one embodiment, the notch 446 is formed when the tip, body fluid sample from the incision contact portion 444 travels along the groove 448 toward the capillary by capillary action, so that the capillary groove 448 is located at the tip 446 from the incision in the skin of the user collecting body fluid sample.在一个实施例中，合适的体液试样尺寸为大约90纳升（nanoliter)。 In one embodiment, a suitable body fluid sample dimensions of about 90 nanoliters (nanoliter).

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[0073] 在驱动器436达到其最大延伸位置之后，驱动器436停止并反向其运动路径。 [0073] After the driver 436 reaches its maximum extended position, the drive 436 to stop and reverse its path of movement.当驱动器436反向其运动路径时，施加到腿部442的力减小且刀尖446从切口缩回。 When the driver 436 reverse their path of movement, the force applied to the leg portion 442 is reduced and the cutting edge 446 is retracted from the incision.由于每个刀424的弹性属性，所以刀尖446自身弹回到室432中的其原始位置。 Due to the elastic properties of each blade 424, so that tip 446 itself spring back to its original position in the chamber 432.在该最终位置中， 起作用的刀424的刀尖446接触测试段428，且体液试样从毛细槽448通过刀424的刀尖446和测试段4¾上的化学物之间的优先毛细作用而释放到测试段4¾上。 In this final position, the blade tip 424 to function test section 428 of the contact 446, 448 and the body fluid sample from the capillary groove by preferential capillary action between the cutting edge 424 of the knife 446 and on the chemical composition and the test section 4¾ released into the test section 4¾.刀似4保持在其最终歇置位置中，其中接触部分444靠着壁架492歇置。 Like knife 4 is held in its final rest position is set, wherein the contact portion 444 rest against the ledge 492 is set.对于下一个测试，致动机构缩回驱动器436中且旋转测试环框架480，以将下一个对应的测试器开口482和下一个未使用或者无菌的刀4M与驱动器436对齐。 For the next test, the actuating mechanism 436 retracts the drive ring and the rotation of the test frame 480, next to the corresponding opening 482 and test the next unused or sterile knife 436 is aligned with the drive 4M.

[0074] 根据另一实施例的刀框架530、刀轮522和测试环5¾显示在图41、图42、图43和图44中。 [0074] According to another embodiment the knife frame 530, the cutter wheel 522 and 5¾ test ring shown in FIG. 41, FIG 42, FIG 43 and FIG 44.正如从这些图中所认识到的那样，刀框架530与如图33、图35、图36中所显示的刀框架430共享许多的特征。 As appreciated from the above figures, the knife frame 530 with a number of features 33, 35, the knife frame 430 shown in FIG. 36 shared FIG.因此，为了简洁起见，刀框架530中与刀框架430相似的特征将不再讨论。 Therefore, for the sake of brevity, the knife frame 530 will not be discussed with similar characteristics to the knife frame 430.与刀框架430不同的是，刀框架530具有多个壁架592，所述壁架592被构造成在致动之前将刀保持在屈曲的位置中。 Knife frame 430 except that the knife frame 530 has a plurality of ledges 592, the ledge 592 is configured prior to actuation of the knife held in a flexed position.由于刀的弹性和每个壁架592的构造，在刀已经从其对应的壁架592释放之后，刀弹回到其原始未屈曲构造且刀被升举以形成切口。 Due to the configuration of each blade and the resilient ledges 592, after the knife has its corresponding ledge 592 is released, the knife springs back to its original configuration and the knives are not bent to form an incision lift.换言之，从壁架592施加到刀上的张力被释放。 In other words, the ledge 592 is applied to the tension on the blade is released.在刀形成切口且刀返回到其对应的壁架592之后，刀尖接触测试段5¾并将体液试样传输到测试段528。 After forming the notch and the cutter blade returns to its corresponding ledge 592, 5¾ body fluid sample and contacting the cutting edge 528 to the test section the test section.与体液试样从刀的接触部分传输到测试段相比，体液试样从刀尖传输到测试段在体液试样被传输到测试段之前对体液试样需要更小的行进距离。 Compared with the transmission of body fluid sample from the contact portion of the blade to the test section, body fluid sample from the tip to the need to travel a smaller distance before testing the body fluid sample to the test section segments are in the body fluid sample.与刀的其他部分相比，来自刀尖的体液试样的传输导致了关于切缝和测试事件的更高的成功率。 Compared to other portions of the blade, from the tip of the body fluid sample transport results in a higher success rate of about lancing and testing events.在该实施例以及如图33、图34、图35、图36、图37、图38和图39中所示的实施例的一些临床试验中，关于体液试样到测试段的刀尖传输的成功率大于93%。 In this embodiment and embodiment 33, FIG 34, FIG 35, FIG 36, FIG. 37, several clinical trials of the embodiment shown in FIG. 38 and FIG. 39, the transfer tip body fluid sample to the test as shown on segment the success rate of greater than 93%.在一些实施例中，包括形成切口、收集体液试样和分析体液试样的总测试时间小于1秒。 In some embodiments, including forming an incision, total test time collection and analysis of a body fluid sample is a body fluid sample of less than 1 second.

[0075] 刀框架530包括限定多个室532的多个壁534。 [0075] The frame 530 comprises a cutter defining a plurality of chambers of the plurality of walls 534,532.刀框架530也包括多个壁架592。 Knife frame 530 also includes a plurality of ledges 592.每个壁架592的尺寸设定成接纳刀524的接触部分M4。 Each ledge 592 is sized to receive the blade contact portion M4 524.壁架592中的一个定位在多个室532的每个中。 A ledge 592 positioned in each of the plurality of chambers 532.在所示的实施例中，多个壁架592大体是矩形的。 In the illustrated embodiment, a plurality of ledges 592 is generally rectangular.每个壁架592也包括缺口593，所述缺口593构造成接纳刀尖讨6，如下面更详细地描述。 Each ledge 592 also includes a notch 593, the notch 593 is configured to receive a tip discuss 6, as described in more detail below.多个开口594被定位在多个壁534和多个壁架592之间。 A plurality of openings 594 are positioned between a plurality of walls 534 and a plurality of ledges 592.每个开口594的尺寸设定成接纳驱动器。 Each size of the opening 594 is sized to receive drive.

[0076] 刀轮522定位在刀框架530中，如图41中所示。 [0076] The cutter wheel 522 is positioned in the tool frame 530, as shown in FIG 41.刀轮522与如图33、图37中所示的刀轮422共享许多的特征。 And the cutter wheel 522 in FIG. 33, the cutter wheel shown in FIG. 37422 share many features.因此，为了简洁的目的，将不再讨论刀轮522和刀轮422中共同的特征。 Thus, for brevity, will not be a common feature of cutter 522 and cutter wheel 422 discussion.

[0077] 测试环5¾显示在图41中。 [0077] 5¾ test loop 41 is shown in FIG.测试环526与图33、图37中所示的测试环似6共享许多的特征。 Test ring 526 and FIG. 33, the test ring 37 shown in FIG. 6 like share many features.因此，为了简洁的目的，将不再讨论测试环5¾和测试环426中共同的特征。 Thus, for brevity, will not be a common feature test test ring 426 and ring 5¾ discussed.测试环5¾包括多个测试段528。 5¾ test ring segments 528 includes a plurality of test.测试环5¾定位在刀框架530上，使得每个测试段5¾被定位在刀框架530的一对壁534之间。 5¾ test loop is positioned on the knife frame 530, such that each of the test sections 5¾ is positioned between a pair of walls 534 of the tool frame 530.

[0078] 在初始位置中，刀尖546定位在缺口593中，使得接触部分M4靠着壁架592歇置， 以限制刀5M运动，直到驱动器接合刀524以将刀尖546从缺口593释放时为止。 [0078] In the initial position, the tip 546 is positioned in the notch 593, so that the contact portion M4 rest against the ledge 592 is set, in order to restrict movement of the knife 5M, until the driver blade 524 to engage the cutting edge 546 is released from the notch 593 until.在该初始位置中，每个壁架592朝向刀缘523延伸，以朝向柔韧性腿部542弯曲接触部分M4。 In this initial position, each of the ledges 592 extending toward the knife edge 523, leg portions 542 toward the flexible curved contact portion M4.随着刀5M从初始位置移动到切口形成位置，接触部分544经过缺口593和壁架592，并且刀尖546沿着垂直于刀框架530的方向移动。 As the blade moves from an initial position to a 5M slit forming position, the contact portions 544,592, 546 and tip blade frame 530 moves in a direction through the notch 593 and the vertical ledge.在接触部分544经过壁架592之后，由于每个刀524的弹性属性，接触部分544弹回到其原始构造。 After the contact portion 544 in the ledge 592, since the elastic properties of each blade 524, the contact portion 544 springs back to its original configuration.随着刀尖546移动，刀尖546穿刺用户的皮肤，该皮肤已经放置在对应的室532之上。 With the movement of tip 546, tip 546 piercing the user's skin, the skin has been placed over the corresponding chamber 532.在一个实施例中，当刀尖546形成切口时， 来自切口的体液试样通过毛细作用沿着毛细槽548朝向接触部分544行进，从而毛细槽548 在刀尖546位于用户的皮肤内时从切口收集体液试样。 In one embodiment, when the tip 546 form an incision, the incision from the body fluid sample by capillary action toward the contact portion 544 travels along the capillary grooves 548, 548 so that when the notch from the groove in the tip of the capillary 546 in the user's skin collecting body fluid sample.在驱动器或者其他机构到达其最终的延伸位置时，驱动器停止且反向运动路径。 When the drive or other mechanism reaches its final extended position, the drive stops and reverse motion path.当驱动器反向其运动路径时，施加到腿部542 上的力减小，且刀尖546从切口缩回。 When reverse drive of its path of movement, the force applied to the leg portion 542 is reduced, and the tip 546 is retracted from the incision.在其最终位置中，起作用的刀524的接触部分544靠着壁架592歇置，并且体液试样从毛细槽548传输到对应的测试段528。 In its final position, the contact acting portion 544 of the blade 524 rest against the ledge 592 is set, and the body fluid sample from the capillary grooves 548 corresponding to the test section 528.

[0079] 根据另一实施例的刀框架630、刀轮622和测试环6¾显示在图45、图46和图47 中。 [0079] According to another embodiment the knife frame 630, the cutter wheel 622 and the test ring shown in FIG 6¾ 45, 47 in FIG. 46 and FIG.如这些特征中所认识到的那样，刀框架630与图33、图35、图36中所示的刀框架430 共享了许多的特征。 As these features are recognized as the knife frame 630 in FIG. 33, FIG 35, FIG 36 the knife frame 430 shown in shared many features.因此，为了简洁的目的，将不再讨论刀框架630和刀框架430中相同的特征。 Thus, for brevity, will not be the same feature 430 knife blade frame 630 and the frame discussed.如下所讨论，刀框架630包括被构造成约束多个刀624的多个板条692，所述多个板条692被构造成约束多个刀624，使得多个刀6M在致动之前没有接触多个测试段628。 As discussed below, the knife frame 630 comprises a plurality of knives is configured to constrain the plurality of slats 624 to 692, the plurality of slats 692 is configured to constrain a plurality of knives 624, such that a plurality of 6M blade is not in contact prior to actuation plurality of test sections 628.有益地，多个板条692被构造成对刀尖646施加力，以在刀尖646已经收集体液试样之后，接触测试段和将体液试样传输到测试段。 Advantageously, a plurality of slats 692 tip 646 is configured to apply a force to the cutting edge 646 after the body fluid sample has been collected, a test section and contacting a body fluid sample to the test section.如上所提及地，将体液从刀尖进行传输与体液从刀的接触部分或者任何其他部分相比需要更小的血液行进距离。 As mentioned above, the body fluid from a body fluid tip transmitted requires less blood as compared to the travel distance from the contact portion or any other portion of the blade.

[0080] 刀框架630包括限定多个室632的多个壁634，如图45、图46、图47中所示。 [0080] The frame 630 includes a plurality of blade walls defining a plurality of chambers 632, 634, FIG. 45, 46, 47 shown in FIG.刀框架630也包括多个板条692。 Knife frame 630 also includes a plurality of slats 692.在多个室632中的每个内定位一对板条692。 Within each of the plurality of chambers 632 in position a slat 692.每个板条692 附接到壁634中的一个。 Each slat 692 is attached to a wall 634.在一对板条692的每个之间是板条开口694。 Between a pair of slats 692 are each slat opening 694.一对板条692也被设定尺寸且定位在壁634上，以在刀6M位于其初始位置时将刀624的刀尖646接纳在板条开口694中。 One pair of slats 692 are also sized and positioned in the upper wall 634, when the cutter to 6M in its initial position 624 of the knife tip 646 received in the opening 694 in the slat.一对板条692还被设定尺寸且定位成当刀6M处于其最终位置时约束刀624。 One pair of slats 692 is further sized and positioned to constrain 6M knife 624 when the knife is in its final position.在刀624已经被致动且歇置在最终位置中之后，一对板条692将一对突起645约束在一对板条692和刀框架630之间。 After the tool 624 has been actuated and is placed in the final rest position, the pair of slats 692 to a pair of projections 645 constrained between a pair of slats 692 and the frame 630 knife.在所示的实施例中，多个板条692的每个大体上是矩形的。 In the illustrated embodiment, each of the plurality of slats 692 are generally rectangular.多个板条692的每个与壁634的每个形成角Θ。 Each of the plurality of slats 692 each forms an angle Θ with the wall 634.角θ是锐角。 Angle θ is an acute angle.

[0081] 刀轮622被定位在刀框架630中，如图45中所示。 [0081] The cutter wheel 622 is positioned in the tool frame 630, as shown in FIG 45.刀轮622包括与图33、图37和图38中所示的刀轮422共同的许多个特征；因此，为了简洁起见，刀轮622和刀轮422中共同的特征将不再讨论。 Includes a cutter wheel 622 in FIG. 33, the cutter wheel 37 shown in FIG. 38 and FIG. 422 common to a plurality of features; thus, for the sake of brevity, the features common cutter wheel 622 and cutter wheel 422 will not be discussed.刀轮622包括刀缘623，所述刀缘623包括多个从刀缘623径向向内延伸的多个刀624。 Cutter wheel 622 includes a knife edge 623, a knife edge 623 of the blade comprises a plurality of a plurality of radially extending knife 623 from the edge 624 inwardly.每个刀拟4包括柔韧性腿部642、接触部分64和刀尖646。 Each knife comprises a flexible leg portion intended to 4 642, the contact portion 64 and the tip 646.每个刀624 的接触部分644包括一对突起645，所述突起645尺寸设定成在刀6¾处于初始位置中时歇置在刀框架630的一对板条692上。 The contact portion 644 of each blade 624 includes a pair of protrusion 645, the protrusion 645 sized to rest in the 6¾ knife placed on a pair of slats 692 of the knife frame 630 in the initial position.在刀624已经被致动且歇置在其最终的位置中时， 一对板条692将一对突起645约束在一对板条692和刀框架630之间。 When the lancet 624 has been actuated and is placed in its final rest position, the pair of slats 692 to a pair of projections 645 constrained between a pair of slats 692 and the frame 630 knife.每个刀6M也限定槽647，槽647尺寸设定成接纳驱动器的尖端。 Each slot 647 also defines knife 6M, groove 647 sized to receive the drive tip.在一个实施例中，刀尖646限定毛细槽(未示出）。 In one embodiment, the tip 646 defines a capillary groove (not shown).

[0082] 测试环拟6与如图41、图42和图44中所示的测试环5¾共享许多个相同的特征， 因此为了简洁的目的，测试环6¾和测试环5¾中共同的特征将不再进行讨论。 [0082] FIG. 6 is intended to test ring 41, the ring test 5¾ FIG. 42 and 44 share the same plurality of features, so for brevity, and the test loop test loop 6¾ 5¾ common features will not be further discussion.测试环6¾ 包括多个测试段628。 6¾ test ring segments 628 includes a plurality of test.测试环6¾被定位在刀框架630上，使得每个测试段6¾被定位在刀框架630的一对壁634之间。 6¾ test ring is positioned on the knife frame 630, such that each of the test sections 6¾ is positioned between a pair of walls 634 of the tool frame 630.

[0083] 在初始位置中，刀尖646定位在板条开口694中，使得一对突起645靠着一对板条692歇置以约束刀6M运动，直到驱动器接合刀6M以移动刀6M并将一对突起645从所述对板条692中释放时为止。 [0083] In the initial position, the tip 646 is positioned in the opening 694 in the strip, so that a pair of protrusions 645 rest against one pair of strips 692 is set to constrain the movement of the knife 6M, until the driver engages a knife blade to move 6M 6M and At the time of a pair of projections 645 is released from the slat 692.此外，在初始位置中，当一对突起645被靠着板条692推动时， 刀6M的弹性导致接触部分644弯曲。 Further, in the initial position, when the pair of projections 645 are driven against the strip 692, the resilient blade causes the contact portion 644 6M bent.随着驱动器将刀6M从初始位置移动到切口形成位置，接触部分644经过一对板条692且释放接触部分644上的压缩力。 As the knife drive 6M cutout from an initial position to a forming position, the contact portion 644 via a pair of slats 692 and releasing the compression force on the contact portions 644.由于每个刀M的弹性属性，所以刀尖646弹回到未压缩构造。 Since the elastic properties of each knife M, so that the cutting edge 646 springs back to an uncompressed configuration.当刀拟4从初始位置移动到切口形成位置时，刀尖646沿着垂直于刀框架630的方向移动。 When the knife 4 is moved from the initial position intended to position the incision is formed, in the direction of the blade tip 646 moves along the vertical frame 630.随着刀尖646移动，刀尖646穿刺已经放置在对应的室632之上的用户的皮肤。 With the movement of tip 646, the piercing tip 646 has been placed over the corresponding chamber 632 of the user's skin.在一个实施例中，当刀尖646形成切口时，来自切口的体液试样通过毛细作用沿着毛细槽朝向接触部分644行进，从而毛细槽在刀尖646处于用户的皮肤中时收集来自切口的体液试样。 In one embodiment, when the tip 646 form an incision, the incision from the body fluid sample by capillary action along the capillary toward the contact groove portion 644 travels to the capillary tip 646 is collected in the groove when the skin of the user from the incision body fluid sample.在驱动器或者其他机构达到其最终的延伸位置时， 驱动器停止且反向其运动路径。 When drive or other mechanism reached its final extended position, the drive stops and the reverse path of movement thereof.在驱动器反向其运动路径时，施加到腿部642上的力减小且刀尖646从切口缩回。 When reverse drive of its path of movement, the force applied to the leg portion 642 is reduced and the cutting edge 646 is retracted from the incision.由于刀624已经返回到未压缩构造，所以一对突起645滑动到一对板条692之后，以将刀6¾约束在最终的位置中且允许刀尖646接合测试段628。 Since the lancet 624 has been returned to the uncompressed configuration, the pair of projections 645 slide after a pair of slats 692, constrained to the knife 6¾ final position and allows the engaging tip 646 test section 628.在其最终位置中，刀6M靠着测试段6¾歇置，且体液试样从毛细槽或者刀尖646传输到对应的测试段似8。 In its final position, the knife against 6M 6¾ rest opposite the test section, and a body fluid sample from the capillary groove 8 like nose 646 or transmitted to the corresponding test section.

[0084] 图48A和图48B是在致动之前约束刀使得刀不接触测试段的一种技术的示意性图示。 [0084] FIGS. 48A and 48B are actuated before the knife so that the blade does not contact the constraint technique test section of a schematic illustration.如图48A中所示，刀靠着框架中的缺口歇置，使得框架的位置导致在刀中的压缩力。 As shown in FIG 48A, the knife gap against the rest of the frame is set so that the position of the frame results in a compressive force in the blade.在致动刀之后，刀从缺口释放且返回到未压缩状态。 After the activated tool, it is released from the knife gap and returns to an uncompressed state.然后，刀形成切口并且在刀尖中收集体液试样。 Then, the knife and form an incision in a body fluid sample collected in the tip.如图48B中所示，处于未压缩状态中的刀尖接触测试段以将来自刀的体液试样传输到测试段。 As shown in FIG. 48B, the cutting edge is in contact with the test section in the uncompressed state to the transmission of body fluid sample from the cutter to the test section.测试段的位置允许未压缩的刀接合测试段并将体液试样传输到测试段。 Position of the test section allows uncompressed knives engage and transport the sample fluid to the test section the test section.有益地， 刀不接触测试段，直到刀将体液试样传输到测试段时为止，因此测试化学物保持不活动。 Advantageously, the knife does not contact the test section, until the knife body fluid sample to the test section until the time, so the test chemicals remains inactive.刀的弹性允许其在从缺口释放之后返回到未压缩状态，因此不需要额外的机构来让刀返回到未压缩状态并将体液试样传输到测试段。 The elastic blade allows it to return to an uncompressed state after release from the notch, so no additional means to allow the knife to return to an uncompressed state and the sample transport body fluid to the test section.

[0085] 图49A和图49B是在致动之前约束刀使得刀不接触测试段的一种技术的示意性图示。 [0085] FIGS. 49A and 49B are actuated before the knife so that the blade does not contact the constraint technique test section of a schematic illustration.有益地，测试段上的测试化学物质保持不活动和未接触。 Advantageously, the test chemicals on the test section remains intact and untouched.如图49A中所示，刀靠着壁架歇置，使得壁架的位置导致刀中的压缩力。 As shown in FIG 49A, the knives rest against the opposing ledge, the ledge such that the position of the knife results in a compressive force.在致动刀之后，刀从壁架释放且返回到未压缩状态。 After the activated tool, tool holder is released from the wall and returns to an uncompressed state.然后，刀形成切口，并且将体液试样收集在刀尖中。 Then, forming an incision knife, and the body fluid sample is collected in the tip.如图49B中所示，未压缩状态中的刀尖接触测试段，以将体液试样从刀传输到测试段。 As shown in FIG. 49B, the contact tip of the test section uncompressed state, to the body fluid sample from the knife to the test section.有益地，不需要其他机构来让刀返回到未压缩状态和将体液试样传输到测试段。 Advantageously, no other means to allow the knife to return to an uncompressed state and a body fluid sample to the test section.测试段的位置允许未压缩的刀接合测试段并将体液试样传输到测试段。 Position of the test section allows uncompressed knives engage and transport the sample fluid to the test section the test section.

[0086] 图50A和50B是在致动之前约束刀又一种技术的示意性图示，从而使得刀没有接触测试段，因此测试段上的测试化学物保持不活动和未接触。 [0086] FIGS. 50A and 50B are constrained knife prior to actuation of a further schematic illustration of the technique, so that the blade is not in contact with the test section, the test chemicals on the test section remains intact and untouched.在如图50A中所示的第一位置中，第一带约束刀，使得所述带的位置在刀中产生压缩力，且刀屈曲或者弯曲。 In the first position as shown in FIG 50A, a first knife with constraints, such that the position of the belt compressive force is generated in the knife, and the knife bent or curved.接着，刀被致动，并且刀穿透第一带以在皮肤中形成切口并收集体液试样。 Subsequently, the knife is actuated, and the knife penetrates the first band to form an incision in the skin and collecting a body fluid sample.在致动期间，刀返回到其未压缩形状。 During actuation, the knife returns to its uncompressed shape.如图50B中所示，在收集体液试样之后，在刀返回到第一位置时刀尖接触第二带，所述第二带包括测试段。 As shown in Fig. 50B, after collecting a body fluid sample, upon return to the first position the knife cutting edge contacts the second tape, the second tape includes a test section.刀尖中的体液试样从刀尖传输到第二带上的测试段。 Body fluid sample is transferred from the tip of the nose section to the second tape test.

[0087] 图51A和图51B是在致动之前约束刀的又一种技术的示意性图示，使得刀没有接触测试段，因此测试段上的测试化学物保持不活动和未接触。 [0087] FIGS. 51A and FIG. 51B is a schematic representation of a further technique constraints prior to actuation of the knife, the knife so that there is no contact with the test section, the test chemicals on the test section remains intact and untouched.如图51A中所示，刀尖歇置在由软材料所制成的盖中，使得盖的位置在刀中导致了压缩力。 As shown in FIG 51A, a tip cap disposed in rest made of a soft material such that the position of the cover results in a compressive force in the knife.在致动刀之后，刀被驱动通过软盖，并且返回到未压缩状态。 After the activated tool, the knife is driven through the soft cover, and returns to an uncompressed state.在刀被驱动通过盖时，盖接着在刀尖形成切口时沿着刀的一部分往下滑并收集体液试样。 When the knife is driven through the cover, the cover then forming an incision in a portion of sliding down along the blade tip and collecting a body fluid sample.如图51B中所示，刀已经返回到其原始位置，且刀尖接触测试段以将来自刀的体液试样传输到测试段。 As shown in FIG 51B blade has returned to its original position, and the contact tip section to transmit a test body fluid sample from the blade to the test section.有益地，不需要其他机构来让弹性刀返回到未压缩状态和将体液试样传输到测试段。 Advantageously, no other means to make the elastic blade returns to an uncompressed state and a body fluid sample to the test section.测试段的位置允许未压缩的刀接合测试段并将体液试样传输到测试段。 Position of the test section allows uncompressed knives engage and transport the sample fluid to the test section the test section.

[0088] 图52A和图52B是在致动之前约束刀的又一种技术的示意性图示，使得刀没有接触测试段，因此测试段上的测试化学物质保持不活动和未接触。 [0088] FIGS. 52A and FIG. 52B is a schematic representation of a further technique constraints prior to actuation of the knife, the knife is not in contact such that the test section, the test chemicals on the test section remains intact and untouched.如图52A中所示，刀包括沿着轨行进的突起，使得轨的位置导致刀弯曲或者压缩。 As shown in FIG 52A includes a knife traveling along a projection of the rail, so that the track position causes the blade bending or compression.在致动刀之后，沿着轨驱动突起，直到突起清除该轨，由此释放刀上的压缩力且刀返回到未压缩状态。 After the activated tool, the drive projection along the track until the projection to clear the rail, thereby releasing the compressive force on the knife and the knife to return to an uncompressed state.在突起已经清除轨之后， 刀尖形成切口且收集体液试样。 After the protrusion has cleared the rail, forming an incision tip and collecting a body fluid sample.如图52B中所示，当刀返回到其原始位置时，刀尖接触测试段以将来自刀的体液试样传输到测试段。 As shown in FIG. 52B, when the blade is returned to its original position, the contact tip section to transmit a test body fluid sample from the blade to the test section.有益地，不需要其他机构来让弹性刀返回到未压缩状态和将体液试样传输到测试段。 Advantageously, no other means to make the elastic blade returns to an uncompressed state and a body fluid sample to the test section.测试段的位置允许未压缩的刀接合测试段和将体液试样传输到该测试段。 Position of the test section allows uncompressed blade engaging a test section and transmit the body fluid sample to the test section.

[0089] 图53A和图5¾是在致动之前约束刀的又一种技术的示意性图示，使得刀没有接触测试段，因此测试段上的测试化学物保持不活动和未接触。 [0089] FIGS. 53A and FIG 5¾ is a schematic illustration of a further technical constraints prior to actuation of the knife, the knife so that there is no contact with the test section, the test chemicals on the test section remains intact and untouched.如图53A中所示，刀处于弯曲的构造中，所述弯曲构造靠着刀框架的底层歇置。 As shown in FIG. 53A, the knife is curved configuration, the curved configuration of the frame against the bottom knife rest position.在一种形式中，底层是无菌片。 In one form, the bottom sheet is sterile.刀框架的底层被构造成使得驱动器能穿透所述底层。 The knife bottom frame is configured such that the driver can penetrate the bottom layer.在形成切口且收集体液试样之后，刀嵌入刀框架的底层，且然后刀接触测试段以将体液试样从刀传输到测试段。 After making an incision and collect body fluid sample, knife blade embedded in the bottom of the frame, and then contacted with the test blade segments from the cutter body fluid sample to the test section.



[0090] 根据一个实施例的便携式计量器系统1000显示在图54、图55、图56、图57、图58、 图59、图60、图61、图62、图63、图64、图65、图66、图67、图68、图69和图70中。 [0090] The portable meter system according to one embodiment 1000 shown in FIG 54, FIG 55, FIG 56, FIG 57, FIG 58, FIG 59, FIG 60, FIG 61, FIG 62, FIG 63, FIG 64, FIG 65 FIG 66, FIG 67, FIG 68, FIG 69 and FIG 70.尽管便携式计量器系统1000将参照便携式血糖测试装置来描述，但必须理解，计量器系统1000可以适于测试多种范围的生物流体和流体属性。 Although the portable meter system 1000 will be described, but it must be understood that the meter system 1000 may be adapted to biological fluids and fluid property testing various ranges with reference to a portable blood glucose testing device.参看图54、图55，计量器系统1000包括容纳刀框架130、刀轮122和测试环126的壳体1002。 Referring to FIG. 54, FIG. 55, the meter system 1000 includes a frame 130 accommodating a knife, the knife wheel 122 and the housing 126 of the test 1002 rings.为了简洁的目的，在计量器系统100中仅示意地显示了刀框架130，但是计量器系统1000将参照刀轮122和测试环1¾来进行描述。 For brevity, the metering system 100 only schematically shows the knife frame 130, but the meter system 1000 with reference to cutter wheel 122 and the test ring 1¾ be described.尽管便携式计量器系统1000将参照刀框架130、刀轮122和测试环来描述，但是必须理解的是，计量器系统1000可以适于上述列出的盒和/或刀框架、刀轮和测试环。 Although the portable meter system 1000 with reference to the knife frame 130, cutter wheel 122 and the ring test described, it must be understood that the system 1000 may be adapted to the meter box and / or the blade frame listed above, and the test ring cutter wheel .

[0091] 壳体1002包括前盖1004、门1006、和基部1008，如图54、图55中所示。 [0091] The housing 1002 includes a front cover 1004, gate 1006, and base 1008, as shown in FIG 54, FIG 55 FIG.前盖1004 具有用于显示测试结果以及其他信息的显示器1012。 1004 has a front cover and a display for displaying the test result of the additional information 1012.必须理解，计量器系统1000可以包括其他的输出装置，例如诸如扬声器。 It must be understood, the meter system 1000 may include other output devices, such as a speaker.显示器1012被定位成使得当计量器系统1000被用户的手握持时用户可以容易地观察显示器1012。 Display 1012 is positioned such that when the meter system user can easily observe the display 1012 when the user's hand 1000 is held.门1006包括压力杯1014，所述压力杯1014的尺寸设定成接纳用户的指尖。 Gate 1006 includes a pressure cup 1014, the size of the pressure cup 1014 is sized to receive the user's fingertips.压力杯1014由弹性类型的支撑塑料材料制造，以允许压力杯1014移动，以将来自用户的手指压力的力传输到计量器系统1000中的释放臂1020来发射刀124，如下面更为详细地描述。 Pressure cup 1014 for producing elastic plastic material type of support, to allow the pressure cup 1014 is moved to release the force transmission arm finger pressure from a user to a metering system to transmit 10001020 knife 124, as in more detail below ground description.压力杯1014被定位在刀框架130、刀轮122和测试环1¾ 之上，以关于每次切缝事件来推进刀框架130、刀轮122和测试环126。 Pressure cup 1014 is positioned above the knife frame 130, and cutter wheel 122 1¾ test ring, to lancing event on each frame 130 to propel the knife, the knife wheel 122 and test loop 126.压力杯1014限定开口1015，其中刀IM从所述开口1015出来以在皮肤中形成切口。 1014 1015 pressure cup defining an opening, wherein the opening blade 1015 out from IM to form an incision in skin.压力杯1014的背表面具有一对触发器接头1016，所述触发器接头1016定位成接合释放臂1020的一对突起1021以致动刀124，如下面将更为详细地描述。 The back surface 1014 of the pressure cup has a pair of trigger connector 1016, the connector 1016 triggers the release arm positioned to engage a pair of projections 1020 1021 124 so that the blade, as will be described in more detail below.在一个实施例中，门1006铰接地附接到基部1008， 以允许到计量器系统1000的内部的通路。 In one embodiment, the door 1006 is hingedly attached to the base 1008, to allow the system to meter the internal passage 1000.这样，使用过的刀框架130、刀轮122和测试环126可以用干净的或者新的刀框架、刀轮和测试环替换。 Thus, the used lancet frame 130, cutter wheel 122 and ring 126 can be tested with a clean knife or a new frame, and the test ring cutter wheel replacement.在其他实施例中，门1006可以通过另一机构附接到基部1008。 In other embodiments, the door 1006 may be attached to the base through another mechanism 1008.

[0092] 便携式计量器系统1000包括释放臂1020。 [0092] The portable meter system 1000 includes a release arm 1020.释放臂1020具有一对突起1021，所述突起1021构造成接触一对触发器接触接头1016。 Release arm 1020 has a pair of projections 1021, the projection 1021 is configured to contact one pair of flip-flops 1016 contact joint.释放臂1020包括定位成接合锁并由此释放发条驱动装置1050的触发器1062。 1020 comprises a release arm positioned to engage and thereby release trigger lock spring motor 1050 to 1062.便携式计量器系统1000也包括彼此相互作用的第一齿轮1022、第二齿轮1024、第三齿轮1026，以旋转刀框架130、刀轮122和测试环126，从而关于每次切缝事件推进刀框架130、刀轮122和测试环126。 The portable meter system 1000 also includes a first gear 1022 interact with each other, the second gear 1024 and third gear 1026 to rotate the knife frame 130, cutter wheel 122 and test loop 126, whereupon each lancing event advancement of the knife frame 130, cutter wheel 122 and test loop 126.齿轮10¾被安装到平台10¾ 上，在所述平台10¾中，还已经附接了刀框架130、刀轮122和测试环126。 It is mounted to the gear 10¾ 10¾ platform, the platform 10¾, the knife also has a frame 130 attached to cutter wheel 122 and test loop 126.第一齿轮1022通过第四齿轮IOM驱动，如下面更为详细地描述。 The first gear 1022 is driven by the fourth gear IOM, as described in more detail below.由于齿轮1022、IOM和10¾的相互作用，所以齿轮1022的旋转运动导致齿轮IOM和10¾旋转。 Since 1022, IOM 10¾ interaction and gear, the rotational motion of gear 1022 causes rotation of the gear 10¾ and IOM.

[0093] 便携式计量器系统1000具有下印刷电路板1030和上印刷电路板1032，所述下印刷电路板1030和上印刷电路板1032通过如图64、图65所示的电池1034来提供电力。 [0093] The portable meter system 1000 having a printed circuit board 1030 and the printed circuit board 1032, a battery 1034 provides power to the 64 shown, a printed circuit board 65 and the printed circuit board 1030 through 1032 in FIG.上印刷电路板1032连接到显示器1012。 On the printed circuit board 1032 is connected to display 1012.上印刷电路板1032包括边缘连接器1036。 The printed circuit board 1032 includes an edge connector 1036.下印刷电路板1030包括边缘连接器插座或者槽1038。 The printed circuit board 1030 includes an edge connector socket or slot 1038.边缘连接器插座1038典型地是用来与例如边缘连接器1036之类的阳电连接器一起使用的阴电连接器。 An edge connector socket 1038 is typically used for example, for use with an edge connector 1036 such male electrical connector female electrical connector.当组装时，边缘连接器1036 与边缘连接器插座1038配合，以将上印刷电路板1032连接至下印刷电路板1030。 When assembled, the connector edge 1036 with the edge 1038 with the socket connector to the printed circuit board 1032 is connected to the printed circuit board 1030.

[0094] 便携式计量器系统1000包括驱动第四齿轮1042的马达1040。 [0094] The portable meter system 1000 includes a drive motor 1040 of the fourth gear 1042.引动齿轮1044与第四齿轮1042和第五齿轮1046连接。 Priming gear 044 and fifth gear and the fourth gear 1042 is connected 1046.第四齿轮1042、引动齿轮1044和第五齿轮1046的放置使得马达1040根据齿轮1042、1044和1046的旋转方向能够具有至少两个功能。 Fourth gear 1042, gear 1044 and primer 1046 is placed such that the fifth gear motor 1042, 1044 and 1040 according to the direction of rotation of gear 1046 can have at least two functions.如果第四齿轮1042通过马达1040具有顺时针的旋转，那么刀框架130、刀轮122和测试环1¾ 将关于下一次切缝、采样和测试事件来旋转，这将在下面进行更详细地描述。 If the rotation of the fourth gear 1042 has a motor 1040 through clockwise, then the knife frame 130, and cutter wheel 122 on the test ring 1¾ next slit, sampling and testing events to rotate, which will be described in more detail below.如果第四齿轮1042通过马达1040具有逆时针的旋转，那么发条驱动装置1050被引动以驱动曲柄轴1070，并且在触发之后导致切缝、采样和测试事件，如下面将更为详细地描述。 If the fourth gear 1042 by the motor 1040 has a counterclockwise rotation, the spring motor 1050 is driven to priming the crank shaft 1070, and leads to the slit, and the test sample after triggering event, as will be described in more detail below.

[0095] 如图60、图61和图62中所示，便携式计量器系统1000包括施力弹簧1060。 [0095] As shown in FIG. 60, FIGS. 61 and 62, the portable meter system 1000 includes a biasing spring 1060.便携式计量器系统1000也包括连接到曲柄臂1072的曲柄轴1070。 The portable meter system 1000 also includes a crank arm connected to a crankshaft of 10,701,072.曲柄轴1070具有阻尼器止动突起1200，如图66中所示。 1070 crankshaft damper having a locking protrusion 1200, as shown in Figure 66.曲柄臂1072枢转地连接到翻倾连杆（tip up link) 1074。 1072 crank arm pivotally connected to the tilting rod (tip up link) 1074.翻倾连杆1074连接到接合刀124的驱动器136。 Tip up link 1074 connected to the driver 124 engages the knife 136.便携式计量器系统1000包括单向离合器1080，所述单向离合器1080延伸通过第五齿轮1046和蜗轮驱动器1090。 The portable meter system 1000 includes a one-way clutch 1080, the one-way clutch 1080 that extends through the fifth gear 1046 and worm drive 1090.便携式计量器系统1000具有第一轴承盖1092和第二轴承盖1094。 The portable meter system 1000 having a first bearing 1092 and second bearing cap 1094.第二轴承盖1094具有硬止动件1096。 A second bearing cap having a hard stop 1094 1096.

[0096] 如图63中所示，便携式计量器系统1000包括框架1100。 As shown in [0096] FIG. 63, the portable meter system 1000 includes a frame 1100.框架1100支撑电动机1040、曲柄轴1070、翻倾连杆1074、单向离合器1080和蜗轮驱动器1090。 Frame 1100 supports the motor 1040, the crank shaft 1070, tip up link 1074, the one-way clutch and worm drive 1080 1090.特别地，翻倾连杆1074枢转地安装到框架1100。 In particular, tip up link 1074 is pivotally mounted to the frame 1100.框架1100与下印刷电路板1030紧邻地定位。 The lower frame 1100 and the printed circuit board 1030 positioned in close proximity.

[0097] 图67、图68和图69显示了通过便携式计量器系统1000致动刀124。 [0097] Figure 67, Figures 68 and 69 show a portable meter system 1000 by actuator blade 124.曲柄轴1070、 曲柄臂1072、翻倾连杆1074、驱动器136和刀IM如图67所示处于初始位置中。 1070 crankshaft, the crank arm 1072, tip up link 1074, IM driver 136 and the knife in an initial position shown in FIG. 67.在图67 中，曲柄臂1072处于0度位置或者切口形成前位置。 In Figure 67, the crank arm 1072 is 0 degree position or a cut forming position.用户将手指靠着开口1015放置且朝向基部1008挤压压力杯1014。 User places a finger is placed against the opening and towards the base 1015 1008 1014 Extrusion pressure cup.压力杯1014被构造成允许压力杯1014运动，以传输来自手指压力的力，从而如下所述地致动刀124。 Pressure cup 1014 is configured to allow movement of the pressure cup 1014, to transmit the force from the finger pressure, so that knife actuator 124 as described below.压力杯1014压靠着释放臂1020，以将来自一对触发器接触接头1016的力传输到一对突起1021，以朝向基部1008移动释放臂1020。 Pressure cup 1014 is pressed against the release arm 1020 so as to contact force from the pair of flip-flop 1016 is transferred to the joint a pair of projections 1021, 1008 to move the release arm toward the base 1020.当释放臂1020移动时，触发器1062接合锁并且释放发条驱动装置1050以驱动曲柄轴1070和曲柄臂1072。 When the release arm 1020 moves, the trigger lock 1062 engages and releases spring motor 1050 for driving the crank shaft and the crank arm 1070 1072.

[0098] 如图68中所示，曲柄轴1070沿着逆时针方向与从柄臂1072的初始位置旋转曲柄臂107大致90度。 [0098] As shown in FIG, 1070 in the counterclockwise direction and the crank shaft from an initial position of rotation of the crank arm 107 of the lever arm 1072 is substantially 68 90 °.曲柄臂1072对应地以顺时针方向旋转或者枢转翻倾连杆1074。 Corresponding to the crank arm 1072 rotates in a clockwise direction or a tilting pivot link 1074.曲柄臂1072现在处于90度位置或切口形成位置。 The crank arm 90 is now at position 1072 or incision forming position.当翻倾连杆1074旋转时，驱动器136也以顺时针方向旋转，以将刀尖146旋转通过开口1015，从而在皮肤中形成切口并收集体液试样。 When the tip up link 1074 is rotated, the driver 136 in a clockwise direction to the rotary tip 146 through the opening 1015, thereby forming an incision in the skin and collecting a body fluid sample.刀尖146在几毫秒之内被升举到用户的手指中。 Lifting the cutting edge 146 is the user's finger in a few milliseconds.在一个实施例中，刀尖146可以在大约3-5 毫秒之内被升举到手指中。 In one embodiment, the tip 146 may be lifting the finger within about 3-5 milliseconds.曲柄轴1070的运动导致“快速进入（fast-in)”位置，其中与下面将说明的刀124的缩回相比、刀124在组织中快速地形成切口。 1070 causes movement of the crank shaft 'quick access (fast-in)' position, which will be described below in comparison with the retraction of the knife 124, knife 124 rapidly forming an incision in tissue.[0099] 如图69中所示，曲柄轴1070继续沿着逆时针方向从曲柄臂1072的切口形成位置旋转曲柄臂1072大约180度。 [0099] As shown, the crank shaft 1070 is formed in FIG. 69 position to continue rotation of the crank arm of the crank arm from the notch 1072 in the counterclockwise direction 1072 about 180 degrees.阻尼器止动突起1200接合框架1100以使刀IM缓慢地返回到其最终位置，其中刀尖146接触测试段124。 The damper stopper protrusions 1200 engage the frame so that a knife IM 1100 returns slowly to its final position, wherein the contact tip 146 test section 124.这导致“慢出（slow-out)”位置，其中当与形成切口的刀相比，刀1¾缓慢地返回到其最终的位置。 This results in 'a slow (slow-out)' position, wherein the knife is formed when compared with the incision, the knife 1¾ slowly returns to its final position.在一个实施例中，刀尖146形成切口所需的时间是刀尖146返回到其最终位置所需的时间的10到100倍快。 In one embodiment, the time required to form the tip 146 tip 146 is returned to the cutout 10 to 100 times the time required for its final position faster.曲柄臂1072现在处于离曲柄臂1072的初始位置成270度的位置。 Crank arm 1072 is now in the initial position of the crank arm from a position 1072 of 270 degrees.在该位置，体液试样从刀尖146传输到多个测试段128中的对应的一个。 In this position, body fluid sample from the tip 128 146-1 corresponding to a plurality of test sections.翻倾连杆1074沿着逆时针方向旋转以将驱动器136降低到刀框架130之下，从而清除刀框架，用于旋转到未使用的刀IM和后续的测试事件。 Tip up link 1074 rotates to the driver 136 in a counterclockwise direction to decrease below the knife frame 130, thereby removing the lancet frame, for rotating the knife and subsequent IM unused test event.

[0100] 曲柄轴1070在逆时针方向上从体液传输位置继续旋转曲柄臂1072大约90度到达初始位置，用于后续的切缝、取样和测试事件。 [0100] crankshaft 1070 in the counterclockwise direction from a transmitting position of the body fluid to continue rotation of the crank arm 90 is about 1072 the initial position for subsequent lancing, sampling and testing events.

[0101] 根据一个实施例的便携式计量器系统2000显示在图71、图72、图73、图74、图75、 图76、图77、图78、图79、图80、图81、图82、图83、图84和图85中。 [0101] The portable meter system according to one embodiment 2000 shown in FIG 71, FIG 72, FIG 73, FIG 74, FIG 75, FIG 76, FIG 77, FIG 78, FIG 79, FIG 80, FIG 81, FIG 82 FIG 83, FIG 84 and FIG 85.为了简洁起见，便携式计量器系统2000中和如图54、图55、图56、图57、图58、图59、图60、图61、图62、图63、 图64、图65、图66、图67、图68、图69和图70中所示的便携式计量器系统1000相同的特征将不再讨论。 For simplicity, the portable meter system 2000 in FIG. 54 and FIG 55, FIG 56, FIG 57, FIG 58, FIG 59, FIG 60, FIG 61, FIG 62, FIG 63, FIG 64, FIG 65, FIG 66 , FIG. 67, FIG. 68, the same features as the portable meter system shown in FIGS. 69 and 70 will not be discussed in 1000.现在看图71、图73，计量器系统200包括容纳刀框架130、刀轮122和测试环126的壳体2002。 Turning now to Figure 71, FIG. 73, the metering system 200 includes a frame 130 to accommodate a knife, the knife wheel 122 and the test ring housing 2002126.为简洁起见，在计量器系统2000中只示意地显示了刀框架130，但是计量器系统2000将参照刀轮122和测试环1¾进行描述。 For brevity, the metering system 2000 shown schematically in the knife frame 130, the meter system 2000 with reference to cutter wheel 122 and the test ring described 1¾.尽管便携式计量器系统2000将参照刀框架130、刀轮122、测试环1¾来进行说明，但是计量器系统2000可以适于上述列出的盒和/或者刀框架、刀轮和测试环。 Cassette and / or the knife frame, although the cutter wheel and the portable meter test ring system 2000 with reference to the knife frame 130, cutter wheel 122, a test ring 1¾ be described, but the system 2000 may be adapted to meter listed above.计量器系统2000包括电子触发系统和穿刺深度控制调节系统，而计量器系统100不包括这些特征。 Meter system 2000 includes an electronic triggering system and a penetration depth control adjustment system, the metering system 100 does not include these features.

[0102] 壳体2002包括前盖2004、门2006、和基部2008，如图71中所示。 [0102] 2004 housing 2002 includes a front cover, a door 2006, and base 2008, 71 as shown in FIG.前盖2004具有用于显示测试结果以及其他信息的显示器2012。 The front cover 2004 has a display 2012 displays the test results and other information is provided.必须理解，计量器系统2000可以包括其他的输出装置，例如诸如扬声器。 It must be understood, the meter system 2000 can include other output devices, such as a speaker.门2006包括定位在刀框架130、刀轮122和测试环1¾之上的开口2015。 Gate 2006 includes a frame 130 positioned in the blade, an opening 2015 on a cutter wheel 122 and the ring test 1¾.在致动时，刀尖146从开口2015出来以在皮肤中形成切口。 Upon actuation, the tip 146 out of the opening 2015 to form an incision in skin.计量器系统2000不包括为在其中触发切缝、取样和测试事件的压力杯。 2000 meter system in which the trigger does not include slitting, sampling and testing of pressure cup events.而是，计量器系统2000包括电力传感器(未示出)，所述传感器感测或者检测定位在开口2015之上的手指或者其他身体部位的存在。 Rather, the meter system 2000 includes a power sensor (not shown), the positioning sensor senses or detects the presence of a finger or other body part of 2015 over the opening.在开口2015上检测到手指力之后，马达2040再次启动并且发射刀124以完成切缝、取样和测试事件，如下面更为详细地描述。 After the finger is detected on the opening force 2015, the motor 2040 to start transmitting again and the knife 124 to complete the slit, sampling and testing event, as described in more detail below.

[0103] 便携式计量器系统2000包括用于调节用于切缝事件的多个刀124的每个的穿刺深度的轮2001。 [0103] The portable meter system 2000 comprises a wheel for adjusting a lancing depth of each of the plurality of knife slits 124 of 2001 events.轮2001被旋转以调节刀124中起作用的一个的穿刺深度至浅的深度设置或者深的深度设置，如下将更为详细地描述。 Wheel 2001 is rotated to adjust the piercing depth of a blade 124 to act in a shallow depth deeper depth setting or settings, will be described in more detail below.初始地，轮2001被安装到轴2200的第一端上， 使得刀124中的一个处于浅的深度设置，如图73中所示。 Initially, the wheel 2001 is mounted to a first end of the shaft 2200, so that a knife 124 disposed at a shallower depth, as shown in FIG 73.第一杆2202沿着轴2200的中点安装，所述第一杆2202限定第一槽2204，如图72中所示。 The first lever 2202 is mounted along the midpoint of the shaft 2200, the first lever 2202 defines a first groove 2204, 72 as shown in FIG.安装在轴2200的相反端的是第二杆2212，所述第二杆2212与第一杆2202相似。 Mounted on the opposite end of shaft 2200 is a second lever 2212, the second lever 2212 and 2202 is similar to the first rod.第二杆2212限定第二槽2214。 The second lever 2212 defines a second groove 2214.第一销2206的第一端被构造成装配在第一槽2204中，销2206的第二端构造成装配在第二槽2214 中。 A first end of a first pin 2206 is configured to fit in the first groove 2204, a second end of the pin 2206 is configured to fit in the second groove 2214.当第一杆2202和第二杆2212对应于轮2001从浅的深度设置到深的深度设置的旋转而被旋转时，第一销2206沿着第一槽2204沿第一槽2204和第二槽2214跨接或者在第一槽2204和第二槽2214中滑动。 When the first lever and the second lever 2202 2212 2001 corresponding to the wheel from rotating shallow depth to a deep depth is provided is provided, which is rotated, the first pin along the first groove 2206 along the first groove 2204 and the second groove 2204 2214 slide across the first groove or the second groove 2204 and 2214.第一销2206的中间部分被构造成装配通过限定在中间臂2230中的第一开口2232。 The intermediate portion of the first pin 2206 is configured to fit through the first opening 2232 is defined in the intermediate arm 2230.第一杆2202和第二杆2212 —起工作或者作为一对工作，以控制第一销2206的位置，所述第一销2206设定深度设置为“浅的”或者“深的”穿刺。 A first lever and a second lever 2202 2212-- from work or work as a pair, to control the position of the first pin 2206, pin 2206 is set to the first depth to 'shallow' or 'deep' puncture.

[0104] 如图74中所示，中间臂2230包括限定第一开口2232的上半部分2236。 [0104] As shown in, FIG intermediate arm 742,230 includes a first opening defining upper half 2232 2236.中间臂2230也包括下半部分2238，所述下半部分2238包括第二销2082，所述第二销2082装配在翻倾连杆2074的槽2080中并在所述槽2080中滑动，如下所述。 Intermediate arm 2230 also includes a lower half of 2238, a lower half 2238 comprises a second pin 2082, a second pin 2082 fitted in the sliding groove 2080 and the groove 2080 in the tilting of the link 2074, as follows above.

[0105] 翻倾连杆2074安装在轴2200上。 [0105] tip up link 2074 is mounted on the shaft 2200.翻倾连杆2074附接到与刀124中的每个接合的驱动器136。 Tip up link 2074 is attached to each of the knives 124 engage drive 136.翻倾连杆2074限定槽2080，所述槽2080被构造成接纳中间臂2230的第二销2082。 2074 defines a groove tip up link 2080, the groove 2080 is configured to receive an intermediate pin of the second arm of 20,822,230.

[0106] 计量器系统2000也具有与便携式计量器系统1000不同的致动系统。 [0106] Meter system 2000 also have different portable meter system 1000 actuation system.计量器系统2000包括与曲柄轴2070相似的曲柄轴2070。 Meter system 2000 includes a shaft 2070 similar to the crank of the crankshaft 2070.曲柄轴2070包括具有止动件2252的盘2250， 所述止动件2252被构造成接触处在所使用的刀的最终位置中的曲柄臂2072，如图75、图78 中所示。 Crankshaft 2070 includes a disc stopper of 22502252, the stopper member 2252 is configured to contact with the knife used in the final position of crank arm 2072, 75, 78 shown in FIG.曲柄臂2072与曲柄臂1072相似，但是曲柄臂2072的第一端可旋转地安装到盘2250上。 Crank arm and the crank arm 2072 is similar to 1072, but the first end 2072 of the crank arm is rotatably mounted to the plate 2250.曲柄臂2072的第二端可枢转地附接到中间臂2230。 The second end of the crank arm 2072 is pivotally attached to the intermediate arm 2230.曲柄轴2070具有阻尼器止动突起2200，如图80中所示。 2070 crankshaft damper having a locking protrusion 2200, 80 as shown in FIG.中间臂2230的第二销2082在翻倾连杆2074的槽2080中滑动，以让翻倾连杆2074和对应的驱动器136旋转。 A second intermediate arm 2082 in the pin tip up link slot in sliding 20802074 2230, 136 to allow rotation of tip up link 2074 and corresponding drive.曲柄轴2070、曲柄臂2072、中间臂2230 和翻倾连杆2074的相互作用将在下面进行详细说明。 2070 crankshaft, crank arm 2072, and 2230 interact intermediate arm tip up link 2074 will be described in detail below.

[0107] 计量器系统2000具有引动齿轮2044，所述引动齿轮2044与第四齿轮2042和第五齿轮2046连接，如图73中所示。 [0107] Meter system 2000 has a gear 2044 primer, the primer gear 2044 connected to the fourth gear and fifth gear 2042 2046, 73 as shown in FIG.第四齿轮2042、引动齿轮2044和第五齿轮2046与计量器系统1000的第四齿轮1042、引动齿轮1044和第五齿轮1046相似。 Fourth gear 2042, gear 2044 and primer 2046 and the fifth gear meter system of the fourth gear 10421000, priming gear 1044 and 1046 similar to the fifth gear.

[0108] 计量器系统2000包括如图82、图83、图84和图85中所示的电子触发系统。 [0108] FIG meter system 2000 includes a 82, 83, shown in FIGS. 84 and electron 85 trigger system.具有捕获器2282的触发器凸轮2280被安装到引动齿轮2044。 The cam has a trigger catcher 2282 2280 is mounted to gear 2044 primer.捕获器释放的枢转轴2047跨在捕获器2282的内部。 Capture release of 2047 across the pivot shaft inside the trap 2282.捕获器释放枢的转轴2047具有引导件或者从动销2284。 Release catcher pivot shaft 2047 has a guide member or follower pin 2284.从动销2284 沿着齿轮2044中的凸轮槽2286行进。 22842286 follower pin 2044 travels along the cam groove gear.

[0109] 便携式计量器系统2000包括驱动第四齿轮2042的马达2040。 [0109] The portable meter system 2000 includes a drive gear 2042 of the motor 2040 of the fourth.与马达1040相似， 马达2040依赖于齿轮2042、2044和2046的旋转方向具有至少两个功能。 1040 is similar to the motor, depending on the rotation direction of the motor 2040 and 2046 2042,2044 gear having at least two functions.当马达2040打开时，马达2040转3/4转，然后马达2040停止。 When the motor 2040 is opened, the motor 2040 turns 3/4 of a turn, and the motor 2040 is stopped.当在开口2015上检测到指力时，电动机2040 再次启动并且发射刀124。 When the opening force to the finger 2015 is detected, the motor 2040 to start transmitting again and the knife 124.

[0110] 计量器系统2000也可以关于刀124的用于浅的穿刺深度设置或者深的穿刺深度设置来进行调节，如下面将描述地。 [0110] Meter system 2000 may be shallow or deep penetration depth disposed about the penetration depth for the blade 124 is provided to be adjusted, as will be described below.如图73中所示，定位在第一槽2204、第一开口2232和第二槽2214 (未示出）中的销2206处于浅的穿刺深度设置的初始位置中。 As shown in FIG. 73, positioned in the first groove 2204, a first opening 2232 in the pin 2206 and the second groove 2214 (not shown) in an initial position shallower penetration depth settings.如果如图76中所示，需要刀124中起作用的一个的深的穿刺深度，那么轮2001旋转，这导致被附接的轴2200旋转且第一杆2202和第二杆2212 (未示出）枢转，这转而又导致第一槽2204、第一开口2232和第二槽2214 (未示出）中的销2206向下或者朝向曲柄臂2072移动。 As shown in FIG. 76, if required deep penetration depth knife 124 in a function, then wheel 2001 to rotate, which results in the shaft 2200 is attached and the rotation of the first lever and the second lever 2202 2212 (not shown ) pivot, which in turn causes the first groove 2204, a first opening and a second groove 2232 2206 2214 pin (not shown) in a downward or crank arm 2072 moves.在轮2001 旋转到深的穿刺深度设置时，销2206被定位以让翻倾连杆2074和驱动器136旋转更大的距离，并由此对刀124中起作用的一个施力以移动更大距离，从而形成更深的切口。 When rotated to the deep penetration depth of the wheel 2001 is provided, the pin 2206 is positioned to allow a greater distance tilting link 2074 and the driver 136 is rotated, and thereby the knife 124 functions in a greater force moving distance , thereby forming a deeper incision.

[0111] 图73、图74和图75显示了通过便携式计量器系统2000致动刀IM中起作用的一个，其中计量器系统2000处于浅的穿刺深度设置中，第一销2206定位在中间臂2230的第一开口2232的顶部处。 [0111] FIG. 73, FIG. 74 and FIG. 75 shows a system 2000 by a portable meter to function in the IM blade actuator, wherein the meter system 2000 is disposed in a shallow depth of puncturing, a first pin positioned intermediate arm 2206 a first opening 2232 at the top of 2230.曲柄轴2070、曲柄臂2072、中间臂2230、翻倾连杆2074、驱动器136 和刀IM处于初始位置中，如图73中所示。 2070 crankshaft, crank arm 2072, the intermediate arm 2230, tip up link 2074, IM driver 136 and the knife in an initial position, as shown in FIG 73.在图73中，曲柄臂2072处于0度位置或者切口形成前位置中。 In FIG 73, the crank arm is in the 0 degree position 2072 or incision forming position.用户打开马达2040以让马达2040旋转一转的3/4然后停止。 The user opens the motor 2040 to make one rotation of the motor 2040 3/4 then stop.用户将手指靠着开口2015放置。 User places a finger against the opening 2015 is placed.电传感器感测手指力，且马达2040再次启动。 Electrical sensing finger force sensor, and the motor 2040 to start again.通过马达2040、第四齿轮2042和引动齿轮2044的相互作用，弹簧2050旋转一转。 By the motor 2040, gear 2042 and the fourth gear 2044 primer interaction, springs 2050 makes one rotation.然后，捕获器释放的枢转轴2047被启用，以释放发条驱动装置2050以驱动曲柄轴2070和曲柄臂2072。 Then, the released catcher pivot shaft 2047 is activated to release the spring motor 2050 for driving the crank shaft and the crank arm 2070 2072.

[0112] 如图74中所示，曲柄轴2070从曲柄臂2072的初始位置逆时针方向旋转曲柄臂2072大致90度。 [0112] As shown in FIG. 74, the crank shaft 2070 is rotated counterclockwise approximately 90 degrees crank arm 2072 from the initial position of the crank arm 2072.曲柄臂2072对应地顺时针方向旋转或者枢转中间臂230和翻倾连杆2074。 2072 corresponding to clockwise rotation of the crank arm or pivot arm 230 and the intermediate link 2074 tilting.中间臂2230的第二销2082处于翻倾连杆2074的槽2080的顶部位置中，以让翻倾连杆2074 和对应的驱动器136朝向开口2015旋转驱动器136。 20822230 second intermediate arm pin is in the tilting position of the top of the link 2074 in a groove 2080, 2074 to allow tilting rod 136 and the corresponding drive 2015 toward the opening 136 of the rotary drive.曲柄臂2072现在处于90度位置或者切口形成位置。 2072 crank arm 90 is now in position or incision forming position.随着翻倾连杆2074旋转，驱动器136也顺时针旋转，以将刀尖146旋转通过开口2015，从而在皮肤中形成切口和收集体液试样。 With the tip up link 2074 is rotated, the drive 136 also rotates clockwise, the rotation to the tip 146 through the opening 2015, thereby forming the collected body fluid sample and incision in the skin.刀尖146在几毫秒之内被升举到用户的手指中。 Lifting the cutting edge 146 is the user's finger in a few milliseconds.在一个实施例中，刀尖146可以在大约3-5毫秒之内被升举到手指中。 In one embodiment, the tip 146 may be lifting the finger within about 3-5 milliseconds.与计量器系统1000的曲柄轴1070相似，曲柄轴2070的运动导致“快速进入（fast-in)”位置。 The metering system similar 10701000 crankshaft, the movement of the crank shaft 2070 results in 'quick access (fast-in)' position.

[0113] 如图75中所示，曲柄轴2070从曲柄臂2072的切口形成位置继续沿着逆时针方向旋转曲柄臂2072以大约180度。 [0113] As shown in FIG. 75, the crank shaft 2070 is formed from the incision position of crank arm 2072 continues to rotate counterclockwise along the crank arm 2072 to approximately 180 degrees.止动件2252接触曲柄臂2072，且阻尼器止动突起2200接合框架2100 (未示出），以缓慢地使刀IM返回到其最终位置，其中刀IM接触测试段124。 2252 contacts the stopper 2072 crank arm and the damper stop projections 2200 engage the frame 2100 (not shown), so that the knife IM to slowly return to its final position, wherein the contact blade IM test section 124.这导致与计量器系统1000相似的“慢出（slow-out)”位置。 This results in the meter system 1000 similar to the 'slow the (slow-out)' position.在一个实施例中，刀尖146形成切口所需的时间是刀146返回到其最终位置所需的时间的2倍快。 In one embodiment, the time required to form the cutting edge 146 of knife 146 is returned to the cut-2 times faster than the time required for its final position.曲柄臂2072现在处于离曲柄臂2072的初始位置270度的位置处。 2072 crank arm is now in a position away from the initial position of the crank arm 270 to 2072 degrees.在该最终位置处，体液试样从刀尖传输到多个测试段1¾中的对应一个。 At the end position, body fluid sample from the tip to a plurality of test sections 1¾ corresponding one.如图75中所示，中间臂2230的第二销2082处于翻倾连杆2074 的槽2080的底部中，以让翻倾连杆2074和对应的驱动器136在刀框架130之下旋转驱动器136，使得驱动器136已经清除刀框架130，用于将刀框架130旋转到未使用的刀IM和后续的测试事件。 As shown in FIG. 75, a second intermediate arm pin 20822230 tilting link at the bottom of the groove 2080 in 2074, 2074 to allow tilting links 136 and a corresponding drive rotary drive 136 under the knife frame 130, 136 has been removed so that the driver blade frame 130, frame 130 for rotating the knife blade and a subsequent IM unused test event.

[0114] 曲柄轴2070反向以从体液传输位置沿着顺时针方向旋转曲柄臂2072大约270度到达初始位置，用于随后的切缝、取样和测试事件。 [0114] In the reverse rotation of the crankshaft 2070 from a crank arm body fluid transferring position 2072 in the clockwise direction approximately 270 degrees reaches the initial position for subsequent lancing, sampling and testing events.

[0115] 图76、图77和图78图示了通过便携式计量器系统2000对刀124的致动，计量器系统2000处于深的穿刺深度设置中。 [0115] FIGS. 76, 77 and 78 illustrate a portable meter system 2000 by actuation of knife 124, the meter system 2000 in a deep penetration depth settings.轮2001被旋转以将第一销2206降低到中间臂2230 的第一开口2232的底部，从而对翻倾连杆2074和驱动器136施加力，以比浅的深度设置更进一步旋转，从而导致刀124中起作用的一个的更深的穿刺深度。 Wheel 2001 is rotated to the first pin 2206 is reduced to a bottom of the first opening 2232 of the intermediate arm 2230, to apply a force to the tip up link 2074 and a driver 136, a depth shallower than the set rotating further, thereby causing the knife 124 It plays a role in a deeper penetration depth.曲柄轴2070、曲柄臂2072、中间臂2230、翻倾连杆2074、驱动器136和刀IM如前参照图73、图74和图75所描述操作。 2070 crankshaft, crank arm 2072, the intermediate arm 2230, tip up link 2074, IM driver 136 and the knife as previously described with reference to FIG 73, FIG 74 and FIG 75 described operation.

[0116] 尽管本发明已经参照了附图和前述说明书进行了详细的图示和说明，但是这本质上只是说明性的而不是限制性的，要理解的是，只显示和描述了优选实施例，但是期望落入由所附权利要求限定的本发明的精神之内的所有变型、等同物和修改都得到保护。 [0116] While the invention has been described with reference to the accompanying drawings and foregoing description, a detailed illustration and description, but this is merely illustrative in nature and not restrictive, to be understood that only the preferred embodiments shown and described embodiment , it is desirable to embrace all modifications within the spirit of the invention as defined by the appended claims, modifications and equivalents are protected.说明书中所引用的所有的出版物、专利、专利申请在此都通过引用并入，正如每个单独的出版物、 专利或者专利申请被特别地和单独地指明以通过引用并入并且在文本中完全陈述的那样。 All publications, patents and patent applications cited herein are incorporated by reference as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated by reference and in the text fully set forth above.

Claims (38)

Translated from Chinese
1. 一种设备，包括：集成的盒，所述集成的盒具有嵌入组装的部件，包括：刀轮，所述刀轮具有刀缘，所述刀缘具有从其径向向内延伸的多个刀，所述刀中的每一个都具有腿部和大体上横向于所述腿部延伸的刀尖；以及框架，所述框架具有装蛋箱形状，所述框架具有多个室，以方便将所述刀轮嵌入组装到所述框架上。 1. An apparatus, comprising: an integrated cartridge, said cartridge having an embedded integrated assembling member, comprising: a cutter wheel, said wheel having a cutter blade edge, the blade edge having a plurality of radially inwardly extending therefrom a knife, each of the lancets having a cutting edge and a leg portion extending generally transverse to the legs of the; and a frame, said frame having an egg crate shape, said frame having a plurality of chambers to facilitate the cutter wheel fitted to the frame assembly.
2.根据权利要求1所述的设备，进一步包括：测试环，所述测试环具有化学物的连续条，所述测试环能够分成多个测试段；以及其中所述多个室被构造成将所述测试环分成所述多个测试段，并且所述刀中的每一个与一个测试段紧邻地定位。 2. The apparatus according to claim 1, further comprising: a test loop, the loop having a continuous strip test chemicals, the test ring can be divided into a plurality of test sections; wherein said plurality of chambers and is configured to the test ring is divided into the plurality of test sections, and each of said knife is positioned in close proximity to a test section.
3.根据权利要求2所述的设备，其中所述刀中的每一个都具有接触部分，以接触测试段和将体液试样沉积到所述测试段上，并且所述腿部是弹性的，以在所述刀尖形成切口的第一位置和所述接触部分接触所述测试段的第二位置之间移动。 3. The apparatus according to claim 2, wherein each of the lancets having a contact portion for contacting a test section and a body fluid sample deposited on the test section, and the leg portion is resilient, to form an incision between a first position and in said second position of said tip portion contacts the contacting movement of the test section.
4.根据权利要求3所述的设备，进一步包括：其中所述框架限定多个窗口，所述窗口的尺寸设定成接纳所述刀的接触部分；以及多个盖阻挡件，所述盖阻挡件定位在所述刀缘和所述测试环之间以覆盖所述多个窗口，所述盖阻挡件中的每一个限定槽，所述槽的尺寸设定成接纳所述刀的接触部分，所述多个盖阻挡件能够在第一位置和第二位置之间移动，当在所述第一位置中时，所述盖阻挡件覆盖所述窗口，当在所述第二位置中时，所述槽对齐在所述窗口之上，以暴露所述盖阻挡件之下的所述测试段，从而允许所述刀的接触部分接触所述测试段。 4. The apparatus of claim 3, further comprising: wherein said frame defines a plurality of windows, the window size is set to receive the blade contact portion; and a plurality of stopper cap member, said cap barrier member positioned between the knife edge and the test ring to cover the plurality of windows, said cover member blocking each defining a slot, the slot size is set to receive the blade contact portion, the plurality of lid stopper member is movable between a first position and a second position, when in the first position, the cover member covering the barrier window, when in the second position, the groove is aligned over the window to expose the test section below the lid stopper member, so as to allow the contact portion to contact the test section of the knife.
5.根据权利要求2所述的设备，进一步包括：第一无菌片，所述第一无菌片构造成覆盖所述多个室和所述多个刀尖；其中所述框架包括尺寸设定成接纳驱动器的多个开口；以及第二无菌片，所述第二无菌片构造成覆盖所述多个开口和所述多个室，其中所述测试环、所述第一无菌片以及所述第二无菌片保持未使用的刀的无菌以及未使用的测试段的湿度。 5. The apparatus according to claim 2, further comprising: a first sheet sterile, sterility of the first sheet configured to cover said plurality of chambers and a plurality of said tip; wherein said frame comprises a size setting to receive a plurality of predetermined drive opening; and a second sterile sheet, the second sterile sheet configured to cover the plurality of openings and said plurality of chambers, wherein the test loop, the first sterile sterile sheet and the second sheet holding unused sterile knife and humidity test sections unused.
6.根据权利要求1所述的设备，其中所述刀尖被构造成在皮肤中形成切口，并且所述刀尖包括构造成通过毛细作用收集所述体液试样的毛细槽。 6. The apparatus according to claim 1, wherein the tip is configured to form an incision in skin, and the tip comprises a capillary groove configured to collect the body fluid sample by capillary action.
7.根据权利要求1所述的设备，进一步包括：计量器，所述计量器具有存放在所述计量器中的集成的盒；以及驱动器，所述驱动器构造成接合所述刀的腿部以旋转所述刀，从而利用所述刀尖在皮肤中形成切口。 7. The apparatus according to claim 1, further comprising: a meter, the meter having an integrated cartridge stored in the meter; and a driver, said driver is configured to engage the leg portion of the blade to rotating the blade so that the tip is formed using an incision in the skin.
8.根据权利要求1所述的设备，进一步包括：多个楔形块，所述楔形块由干燥剂材料制成，其中在所述框架的每个室中定位所述楔形块中的一个。 8. The apparatus of claim 1, further comprising: a plurality of wedge-shaped blocks, the wedge block is made of a desiccant material, wherein each chamber of said positioning the frame in a wedge-shaped block.
9.根据权利要求1所述的设备，进一步包括：测试环，所述测试环具有化学物的连续条，所述测试环能够分成多个测试段；其中所述多个室被构造成将所述测试环分成所述多个测试段，并且所述刀中的每一个与一个测试段紧邻地定位；以及测试环框架，所述测试环框架限定多个窗口，所述多个窗口构造成接纳所述测试环，并且构造成便利于通过所述多个窗口对所述多个测试段的观察。 9. The apparatus according to claim 1, further comprising: a test loop, the loop having a continuous strip test chemicals, the test ring can be divided into a plurality of test sections; wherein said plurality of chambers are configured to said plurality of test test ring into the segments, and each of the knife and a section positioned proximate to the test; and a test ring frame, the ring frame defining a plurality of test windows, configured to receive a plurality of windows the test loop, and is configured to facilitate observation by the plurality of windows of the plurality of test sections.
10.根据权利要求9所述的设备，进一步包括：其中所述测试环框架限定了尺寸设定成接纳所述刀的刀尖的多个测试器开口； 第一无菌片，所述第一无菌片构造成覆盖所述多个测试器开口和所述多个刀尖；以及第二无菌片，所述第二无菌片构造成覆盖所述框架的所述多个室，其中所述测试环、所述第一无菌片和所述第二无菌片保持未使用的刀的无菌以及未使用的测试段的湿度。 10. The apparatus according to claim 9, further comprising: wherein said frame defines a test loop sized to receive the tip of the blade a plurality of test openings; a first sterility sheet, the first sterility sheet configured to cover said plurality of openings and said plurality of test tip; and a second sterile sheet, said cover sheet a plurality of said second sterile chamber frame configured, wherein testing said loop, said first sheet and said second sterile sterile sheet remains unused humidity sterile knife and unused test sections.
11.根据权利要求2所述的设备，其中所述刀中的每一个都具有接触测试段和将体液试样沉积在所述测试段上的刀尖，并且所述腿部是弹性的，以便在所述刀尖形成切口的第一位置和所述刀尖接触所述测试段的第二位置之间移动。 11. The apparatus according to claim 2, wherein each of the lancets having a test section and contacting a body fluid sample deposited on the test section of the tip, and the leg portion is resilient so that movement between an incision in the tip of the first and second positions in contact with the tip of the test section.
12.根据权利要求1所述的设备，其中所述框架包括多个板条；以及在所述多个室的每一个中定位所述多个板条中的一对，以在切缝事件之前和在所述切缝事件之后约束所述刀。 Before lancing event to positioning the plurality of slats and a pair of each of the plurality of chambers,; 12. The apparatus of claim 1, wherein said frame comprises a plurality of slats and restrain the blade after the lancing event.
13.根据权利要求1所述的设备，其中所述刀尖中的每一个都被构造成接触测试段和将体液试样沉积在所述测试段上。 13. The apparatus according to claim 1, wherein each of the tip are configured to contact a test section and a body fluid sample deposited on the test section.
14. 一种方法，包括：组装集成的一次性盒，其中所述组装包括：将刀轮嵌入到环形框架中，所述刀轮具有边缘，所述边缘具有多个径向向内延伸的刀， 所述框架具有限定多个室的多个轮辐；以及将所述刀中的每一个定位在所述室的一个中。 14. A method, comprising: assembling an integrated disposable cartridge, wherein said assembly comprises: a wheel fitted into the annular cutter frame, the cutter wheel having an edge, said edge having a plurality of radially inwardly extending blade a frame having a plurality of spokes defining a plurality of chambers; and each of said blade is positioned in one of said chambers.
15.根据权利要求14所述的方法，其中所述组装进一步包括： 将具有化学物的连续条的测试环附接到所述框架上；以及通过所述多个轮辐将所述测试环分成多个测试段，所述测试段中的每一个定位在所述刀中的一个之下。 15. The method according to claim 14, wherein said assembly further comprising: a continuous strip having the chemical test loop attachment thereof to the frame; and a plurality of spokes through the ring into a plurality of the test a test section, of the test sections each positioned in one of said blade below.
16.根据权利要求15所述的方法，其中所述组装进一步包括：将多个能够移动的盖阻挡件定位在所述多个刀和所述多个测试段之间，以消除所述刀和所述测试段之间的接触，直到所述刀和所述对应的盖阻挡件被致动时为止，其中所述盖阻挡件中的每一个限定窗口，以暴露用于由所述刀接触的所述测试段的一部分。 16. The method according to claim 15, wherein said assembly further comprises: a plurality of movable lid stopper member positioned between the plurality of blades and the plurality of test segments, and to remove the blade the contact between the test section, and up until the blade when the lid corresponding to the blocking member is actuated, wherein said cover member blocking each defining a window, to expose the blade for contacting the the part of the test section.
17.根据权利要求15所述的方法，进一步包括： 其中所述刀中的每一个都具有刀尖和弹性的腿部；利用所述刀尖中的一个在组织中形成切口，其中所述腿部处于第一位置中；以及将体液试样从所述刀尖传输到所述测试段，其中所述腿部处于第二位置中。 17. The method of claim 15, further comprising: wherein each said blade having a cutting edge and the elastic leg portion; a tip is formed using the incision in tissue, wherein said leg portion in the first position; and a body fluid sample from the tip to the test section, wherein the leg portion in the second position.
18.根据权利要求14所述的方法，进一步包括：将所述集成的一次性盒装载到计量器中，所述计量器被构造成致动所述多个刀。 18. The method of claim 14, further comprising: the integrated disposable cartridge loaded into the meter, the meter is configured to actuate the plurality of knives.
19.根据权利要求14所述的方法，进一步包括：将干燥剂的轮嵌入到所述环形框架中，所述干燥剂的轮具有带多个楔形块的边缘；以及将所述楔形块中的每一个定位在所述室中的一个内。 19. The method of claim 14, further comprising: a desiccant wheel fitted to the annular frame, the desiccant wheel having a rim with a plurality of wedge-shaped blocks; and said wedge block each positioned in the inner chamber a.
20. 一种方法，包括：提供集成的一次性盒，所述集成的一次性盒包括：框架；刀轮，所述刀轮具有从边缘径向向内延伸的多个刀；以及测试环，所述测试环具有多个测试段，其中所述多个刀接触所述多个测试段；通过将所述刀从所述多个测试段旋转离开来利用所述刀中的一个在组织中形成切口；利用所述刀上的毛细槽收集体液试样；通过朝向所述多个测试段旋转所述刀来使所述刀从所述组织中的切口退出；以及通过将所述测试段与所述刀接触以释放所述体液试样，从而将所述体液试样从所述刀上的毛细槽传输到所述测试段中的一个。 20. A method, comprising: providing an integrated disposable cartridge, the integrated disposable cartridge comprising: a frame; cutter wheel, said wheel having a plurality of cutter blade extending radially inwardly from an edge; and a test ring, the test ring has a plurality of test sections, wherein said plurality of blade contacts said plurality of test sections; by rotation of the blade away from the use of a plurality of test sections to the blade is formed in the tissue incision; capillary groove by the blade on the collected body fluid sample; to the blade by a plurality of said test sections toward the rotary cutter exits from the incision in tissue; and by the test section with the contacting said blade to release the body fluid sample, such that the body fluid sample from the capillary grooves on said one blade into the test section.
21.根据权利要求20所述的方法，进一步包括：其中将所述刀从所述多个测试段旋转离开的步骤包括：相对于所述框架沿着水平方向朝向所述刀移动驱动器以接触所述刀；以及其中朝向所述多个测试段旋转所述刀的步骤包括：相对于所述框架沿着水平方向使所述驱动器从所述刀移动离开。 21. The method of claim 20, further comprising: wherein the step of said blade from said plurality of test sections rotated away comprises: relative to the frame along a horizontal direction toward the blade to contact the driver moves the said knife; and wherein the step of said plurality of test sections toward said rotary cutter comprising: a frame with respect to the said drive along a horizontal direction away from the knife movement.
22.根据权利要求20所述的方法，进一步包括：在将所述毛细槽中的体液试样传输到所述测试段之后，将所述框架调配到未使用的刀。 22. The method of claim 20, further comprising: transmitting in a sample body fluid after said tank to said capillary test section, the formulations to the tool frame unused.
23.根据权利要求20所述的方法，进一步包括：利用所述刀在皮肤中形成第二切口，以获得足够量的体液试样。 23. The method according to claim 20, further comprising: a blade formed with the second cut in the skin, in order to obtain a sufficient amount of body fluid sample.
24. 一种设备，包括： 微取样器轮，包括：基部、多个刀和多个肋，其中所述多个肋和所述多个刀从所述基部径向向外延伸，并且所述多个肋和所述多个刀彼此交替；所述刀中的每一个都具有弯曲的刀尖，所述刀尖构造成在皮肤中形成切口； 所述刀中的每一个构造成在形成所述切口时绕所述基部旋转，所述刀的旋转曲率与所述刀尖的曲率相似；以及所述多个肋中的每一个都定位成参考表面，所述刀尖的穿刺深度从所述参考表面来确定。 24. An apparatus, comprising: microsampler wheel, comprising: a base, a plurality of ribs and a plurality of knives, wherein the plurality of ribs and a plurality of said blade extending radially outwardly from said base portion, and said a plurality of ribs and said plurality of knives alternate with each other; each of said blade having a curved tip, the tip configured to form an incision in skin; each of said blade configured to form the when the base portion about said rotation notch, a curvature similar to the curvature of the rotation of the blade cutting edge; and said plurality of ribs each positioned reference surface, the penetration depth from said cutting edge determining a reference surface.
25.根据权利要求M所述的设备，进一步包括：其中所述多个刀中的每一个都包括腿部、第一腿构件和第二腿构件； 所述腿部附接到所述基部，所述腿部从所述基部延伸到所述第一腿构件，并且所述腿部与所述基部形成第一角，所述第一角度为锐角；所述第一腿构件跨在所述腿部和所述第二腿构件之间，所述第一腿构件与所述腿部形成第二角，所述第二角为钝角；所述第二腿部件跨在所述第一腿构件和所述刀尖之间，其中所述刀尖限定毛细槽；以及多个测试段，所述测试段中的每一个定位成与所述刀中的一个相邻。 25. The apparatus as claimed M claim, further comprising: wherein each of the plurality of lancets comprises a leg portion, a first leg member and the second leg member; said legs attached to said base portion, the leg portion extending from said base to said first leg member, said leg portions and forming a first angle with the base, said first acute angle; across the first leg of the leg member and a portion between the second leg member, said first leg member and said second leg portion forming an angle, the second angle is obtuse; across the second leg member in the first leg member and between said tip, wherein the tip defines a capillary channel; and a plurality of test sections, each positioned adjacent to one of said test section of said blade.
26.根据权利要求25所述的设备，其中：所述毛细槽位于所述刀尖的前面上，并且延伸到所述第二腿构件中；以及所述测试段中的每一个定位成相邻于所述第二腿构件。 26. The apparatus according to claim 25, wherein: said capillary slot is located on the front of the blade edge, and extends into the second leg member; and in each of the test sections positioned adjacent said second leg member.
27.根据权利要求25所述的设备，其中： 所述毛细槽位于在所述刀尖的后面上；以及所述测试段中的每一个定位成相邻于所述刀尖的后面。 27. The apparatus according to claim 25, wherein: the capillary groove is located on the rear of said tip; and in each of the test sections positioned adjacent to the rear of the tip.
28.根据权利要求25所述的设备，其中： 所述毛细槽位于所述刀尖的后面上；第二毛细槽位于所述刀尖上，所述第二毛细槽从所述刀尖的后面延伸到所述刀尖的前面，以将所述体液试样从所述后面传输到所述刀尖的前面；以及所述测试段中的每一个定位成相邻于所述刀尖的前面。 28. The apparatus according to claim 25, wherein: said capillary slot is located on the rear face of said tip; tip on the back of the second groove from the capillary tip of the second capillary groove located extending to the front of the blade edge, to the body fluid sample from the back to the front of the tip; and in each of the test sections positioned adjacent to the front of the blade edge.
29. 一种设备，包括：集成的盒，所述集成的盒具有嵌入组装的部件，包括：刀轮，所述刀轮具有刀缘，所述刀缘具有从其径向向内延伸的多个刀，所述刀中的每一个具有用于将体液试样传输到测试元件的装置；以及框架，所述框架具有用于方便将所述刀轮嵌入组装到所述框架上的装置。 29. An apparatus, comprising: an integrated cartridge, said cartridge having an embedded integrated assembling member, comprising: a cutter wheel, said wheel having a cutter blade edge, the blade edge having a plurality of radially inwardly extending therefrom a knife, the blade of each of the body fluid sample to the test element has means for; and a frame, said frame having means for facilitating embedding the cutter wheel is assembled onto said frame.
30.根据权利要求四所述的设备，其中用于传输所述体液试样的装置包括这样的刀， 所述刀具有接触所述测试元件并且将所述体液试样沉积在所述测试元件上的接触部分。 30. The apparatus according to claim four, wherein said means for transmission comprises a body fluid sample such as a knife, the knife contact of the test element and the body fluid sample deposited on the test element the contact portion.
31.根据权利要求32所述的设备，其中用于传输所述体液试样的装置包括这样的刀， 所述刀具有接触所述测试元件并且将所述体液试样沉积在所述测试元件上的刀尖。 31. The apparatus according to claim 32, wherein said means for transmission comprises a body fluid sample such as a knife, the knife contact of the test element and the body fluid sample deposited on the test element nose.
32.根据权利要求四所述的设备，其中用于方便将所述刀轮嵌入组装到所述框架上的装置包括这样的框架，所述框架具有带多个室的装蛋箱形状。 32. The apparatus according to claim four, wherein said cutter wheel for facilitating assembly fitted to said frame means includes a frame, said frame having an egg crate shape with a plurality of chambers.
33.根据权利要求四所述的设备，其中所述框架包括多个壁架，并且所述多个壁架中的每一个限定了构造成接纳所述刀尖的缺口。 33. The apparatus according to claim four, wherein said frame comprises a plurality of ledges, and wherein each of the plurality of ledges defining a gap configured to receive said blade edge.
34.根据权利要求32所述的设备，其中所述框架包括多个板条，并且在所述多个室中的每一个中定位所述多个板条中的一对以约束所述多个刀中的一个。 34. The apparatus according to claim 32, wherein said frame comprises a plurality of slats, said plurality of slats and positioned in a pair of said plurality of constraints to said plurality of chambers in each of the in a knife.
35. 一种方法，包括：致动第一机构以绕基部构件旋转参考构件，以接触皮肤和形成参考表面，所述参考构件附接到所述基部构件，其中刀尖的穿刺深度相对于所述参考表面进行测量；以及致动第二机构以沿着所述参考构件和刀行进，以绕所述基部构件旋转所述刀，所述刀附接到所述基部构件，其中具有刀尖的所述刀在所述皮肤中形成切口。 35. A method, comprising: a first actuating mechanism to the base member about the rotating reference member to contact the skin and form a reference surface, the reference member is attached to the base member, wherein the penetration depth of the tool tip relative to said reference surface is measured; and a second actuating mechanism along said reference member and cutter travels to the base member about the rotating blade, the blade is attached to the base member, having a tip the blade is formed in an incision in the skin.
36.根据权利要求35所述的方法，进一步包括：所述致动所述第一机构的步骤包括将第一圆柱体挤压成靠着所述参考构件；以及所述致动所述第二机构的步骤包括沿着所述参考构件和所述刀来移动所述第二圆柱体。 36. The method according to claim 35, further comprising: said step of actuating said first means comprises a first cylindrical body extruded against the reference member; and wherein said second actuating step mechanism comprises along said reference member and said second blade to move the cylinder.
37.根据权利要求36所述的方法，其中挤压所述第一圆柱体的步骤包括旋转所述第一圆柱体以靠着所述皮肤来泵送所述参考构件，并且将体液挤出至所述皮肤中的切口。 37. The method according to claim 36, wherein the step of pressing said first cylindrical body comprises a first rotation of said cylinder to the skin to pump against the reference member, and the body fluid to the extrudate the incision in the skin.
38. 一种设备，包括：集成的盒，所述集成的盒具有嵌入组装的部件，包括：刀轮，所述刀轮具有多个刀，所述刀中的每一个都具有腿部和大体上横向于所述腿部延伸的刀尖；以及框架，所述框架具有多个室，以方便将所述刀轮嵌入组装到所述框架上； 测试环，所述测试环具有化学物的连续条，所述测试环能够分成多个测试段，其中所述多个室被构造成将所述测试环分成所述多个测试段，并且所述刀中的每一个与一个测试段紧邻地定位；以及其中所述刀尖中的每一个被构造成接触测试段和将体液试样沉积在所述测试段上，并且所述腿部是弹性的，以在所述刀尖形成切口的第一位置和所述刀尖接触所述测试段的第二位置之间移动。 38. An apparatus, comprising: an integrated cartridge, said cartridge having an embedded integrated assembling member, comprising: a cutter wheel, said wheel having a plurality of cutter knives, each of said blade having a leg portion and a generally continuous loop test, the test ring having chemicals; nose leg portion extending transversely to said upper; and a frame, said frame having a plurality of chambers, to facilitate embedding the cutter wheel is assembled onto said frame strip, the test ring can be divided into a plurality of test sections, wherein said plurality of chambers are configured to test the ring into a plurality of said test sections, and each of said blade in a test section and positioned immediately adjacent ; and wherein each of which is configured to contact a test section and the body fluid sample is deposited on the tip of the test section, and the leg is resilient, the first tip to an incision movable between a contact position and a second position of the test section of the tip.
CN201080042964.2A2009-09-282010-09-16Body fluid lancing, acquiring, and testing cartridge design CN102573631B (en)

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US12/568,009US8961431B2 (en)	2009-09-28	2009-09-28	Body fluid lancing, acquiring, and testing cartridge design
CN102573631AtrueCN102573631A (en)	2012-07-11
CN201080042964.2ACN102573631B (en)	2009-09-28	2010-09-16	Body fluid lancing, acquiring, and testing cartridge design

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EP (1)	EP2482723B1 (en)
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CA (1)	CA2772592C (en)
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    US6202004B1US09/247,213US24721399AUS6202004B1US 6202004 B1US6202004 B1US 6202004B1US 24721399 AUS24721399 AUS 24721399AUS 6202004 B1US6202004 B1US 6202004B1

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    Prior art keywords

    apparatus

    rotary actuator

    Fred M. Valerino, Sr.

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    Crate Gxt 212 Amp

    Criticalpatent/US5805454A/en

    Priority to US08/935,090prioritypatent/US6048086A/en

    Application filed by Fred M. Valerino, Sr.filedPriority to US09/247,213prioritypatent/US6202004B1/en

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    B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL

    B65G51/00—Conveying articles through pipes or tubes by fluid flow or pressure; Conveying articles over a flat surface, e.g. the base of a trough, by jets located in the surface

    B65G51/36—Other devices for indicating or controlling movements of carriers, e.g. for supervising individual tube sections, for counting carriers, for reporting jams or other operating difficulties

    B65G51/46—Automatically distributing the carriers to desired stations according to separate signal systems

• B—PERFORMING OPERATIONS; TRANSPORTING
• B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
• B65G51/04—Conveying the articles in carriers having a cross-section approximating that of the pipe or tube; Tube mail systems

BACKGROUND OF THE INVENTION

In many hospitals large numbers of doses of parenteral products have to be prepared daily, for example intravenous bags and other medications administered intravenously. These doses are usually prepared manually in what is an exacting but tedious responsibility for a highly skilled staff. It is, therefore, an object of this invention to provide an automated dispenser to simplify the manual operations necessary for preparing doses of parenteral products while maintaining the exacting standards set by medical regulatory bodies.

Further, prompt and reliable delivery of parenteral products to the patient is essential to the daily operations of a hospital. Manual delivery can be slow and unreliable, possibly resulting in harm to patients. Pneumatic tube transportation systems are currently used to transfer blood samples, medicines, intravenous bags, viral samples or other biological or chemical matter between locations within a hospital or laboratory quickly and reliably. Thus, it is an object of this invention to combine an automated pneumatic tube system with a robot device apparatus to provide a complete automated system for the efficient processing and delivery of parenteral products within a hospital. Other uses of the present invention include dietary, laboratory, and central supply systems, as well as to prepare and deliver intravenous bags.

Dramatic improvements in industrial productivity and quality have been achieved with the application of robotic technology. Spinoffs of this technology that will impact everyday life include home robots for housecleaning, lawn-mowing and fast food robots. Against this backdrop, hospitals and hospital laboratories across the country are beginning to consider the benefits of robotic automation. Health care traditionally has been a difficult marketplace for automation because of the complexity of the procedures and the potential health risks. Nevertheless, exciting medical applications such as the use of robots as assistants in surgical procedures have recently been described. Robots will have a significant impact on medical care by eliminating mundane chores, reducing the exposure of personnel to AIDS and other infectious diseases, and lowering labor costs.

In confronting increasing pressure to reduce the cost of providing analytical results, many laboratories have centralized their services to conserve resources. By consolidating services, expensive equipment has less idle time and labor is used more cost effectively. However, centralization may adversely affect the sample-to-result turnaround time by increasing the distance of the centralized laboratory from the origin of the specimen. Frequently, analytical results must be obtained in a short time to provide information for rapid assessment of a situation so that corrective actions may be taken. In medical care, for example, the clinical state of a critically ill patient must be assessed and corrected before a life threatening condition occurs. Similarly, in the outpatient clinic, providing results of blood analysis to physicians while the patients are still in the physicians' office is highly desirable because it obviates the need for a return appointment to discuss abnormal laboratory results. In industrial process control, real-time monitoring of the progress of chemical reactions by on-site analytical techniques prevents dangerous conditions or loss of products.

Until now, improvements in the turnaround of results have been obtained either by dedicated rapid specimen transportation systems or by simplifications of analytical techniques that make the specimen analysis faster. Pneumatic tube systems, mobile carts, and robotic messengers have been used with some success to transport specimens rapidly to the central laboratory, or from a central pharmacy to remote stations. The present invention provides a greatly improved delivery system, and is particularly directed to the use of an automated pneumatic tube or other automated system in the distribution and receiving step.

By definition, a robot is any machine that can be programmed to perform any task with human-like skill. Practically, the term robotics refers to programmable devices that can perform a variety of skilled actions by using a combination of mechanical and electronic components. Robots are often considered simply a mechanical extension of the computer. The greatest asset of a robot is that it can be configured to perform a multiplicity of tasks and therefore should wear out before it becomes outmoded. Devices designed for only one repetitive task are referred to as “hard automation,” e.g., auto-samplers, pipetters, and all other instrumentation with limited mechanical capabilities or restricted programmability.

Laboratory robots can take many forms, however, three basic configurations of robots are predominately used in the clinical laboratory environment, although many other robots are available that are suitable for the laboratory environment.

Cartesian robots are devices with three linear degrees of freedom. Items can be moved about in a three-dimensional (x,y,z) space, but not rotated. Cartesian robots are the basis for sampling devices in many automated analyzers. However, Cartesian robots have found more versatility in the clinical laboratory as pipetting stations, designed to perform many liquid-handling activities.

An example of a Cartesian robot would be the Biomek pipetting station (Beckman Instruments, Brea, Calif.) where the robot can be programmed to perform various liquid-handling protocols. Cartesian robot-pipetting stations allow placement of a pipette tip at any point in space, within approximately equal to 0.2 mm repeatability, with the capability of aliquoting and diluting specimens and dispensing reagents. Cartesian robot-pipetting stations have as their principal components microprocessor-controlled stepping motors that drive liquid-handling syringes, pipetting arms, and in some units movable sample trays.

The Biomek is a hybrid robot in that it has a series of interchangeable hands that allow it to vary its pipetting capabilities. However, the Biomek cannot mechanically manipulate test tubes. In addition, it comes equipped with a built-in spectrophotometer. The Biomek and other similar pipetting stations can be programmed to perform other useful liquid-handling chores such as washing an antibody-coated bead, or rinsing the wells in a microtiter plate.

Recently the Biomek has been configured to perform a monoclonal solid-phase immunoenzymatic assay for carcinoembryonic antigen (Hybritech Inc., San Diego, Calif.). Because of the Biomek's built-in spectrophotometer, the entire assay, including bead washing and data reduction, is handled automatically.

There are several examples in the clinical laboratory of the use of pipetting stations to perform analytical procedures. Brennan et al demonstrated the use of the Tecan Sampler 505 (Tecan AG, Hombrechtikon, Switzerland) in the screening test for anti. HTLV-III antibodies. The procedure required placing a patient's plasma sample in a rack, after which the pipetting station diluted the plasma 441-fold. A barcode reader and pipette washer were retrofitted to the device to positively identify patients and to eliminate carry-over, respectively. The system operated at approximately the same rate as a trained medical technologist but demonstrated better precision and allowed technologists to perform other tasks.

The cylindrical robot, exemplified by the Zymate robot (Zymark Corp., Boston, Mass.) works in a cylindrical performance envelope. The four degrees of freedom exhibited by cylindrical robots (base rotation, elevation, movement in and out of a plane, and wrist roll) are usually sufficient for most laboratory operations. The major limitation of these robots is the lack of wrist pitch, which would be useful for getting in and out of tight places. Additional flexibility in task performance is obtained by programming the robot to use a series of interchangeable hands (a feature patented by Zymark Inc.). Hand and finger orientation is determined by potentiometric servo motors that allow the robot to “sense” its orientation at all times. This arm is a popular choice for simple repetitive tasks and has been used successfully for many sample-preparation protocols, both in the clinical laboratory and in the pharmaceutical industry.

The use of a cylindrical robotic arm to produce an automated blood-typing system that would be affordable to most laboratories has been investigated. The system consists of an indexing rack for samples, which are identified by a barcode reader. After significant development over several years, the system was described again, with throughput increased from 40 to 104 samples per hour. The device was later commercialized by Microban (Dynatech Laboratories, Chantilly, Va.). The success of robotic applications in the blood bank is due to the production line nature of blood typing. Laboratory services that support blood banks require many repetitive analyses before the blood can be used for transfusion. It has been estimated that, in 1984, 12 million units of whole blood were collected in various medical centers, each unit of which required ABO and Rh typing. The blood-typing process has been automated by some manufacturers, but these units cost greater than $100,000 and so are not accessible to most regional hospitals with small transfusion volumes. Robotic arms not only are less expensive than a dedicated blood-typing instrument but also can be reprogrammed when the laboratory's needs change.

The cylindrical robot has been used in the clinical chemistry laboratory at the Cleveland Clinic Foundation to prepare samples for an HPLC method in a complex series of steps: sample extraction, separation of liquid phases, and injection. These investigators incorporated several Zymate robotic systems into a laboratory for the analysis of antidepressants. Medical technologists were needed to prepare the reagents, to place necessary supplies at the designated locations within reach of the robot, and to evaluate the quality of the final results. The robotic laboratory was placed under a fume hood to eliminate any toxic fumes originating from extracted samples during the evaporation process. The robot completed the drug extractions and made the sample injection into the chromatograph by using a specially designed injection hand. For several years these robots have been performing their repetitive tasks with only minor malfunctions.

The use of a robot to perform preparative immunologic precipitations, with final placement of the samples into a rotor for subsequent analysis has been recently reported. This robotic system, which consisted of a Zymate robot and a Cobas-Bio rotor (Roche Diagnostics, Nutley, N.J.), was the first reported system to combine a clinical analyzer and a laboratory robot. However, placing the rotor in the analyzer and transferring the data to the laboratory computer were performed manually.

The Vancouver General Hospital has automated a highly complex steroid-receptor analysis, using a Zymate robotic system. The estrogen receptor assay ordinarily is a manual procedure, involving many critical steps such as centrifugation, incubation, and subsequent placement of completed samples in scintillation vials. In the automated procedure, the incubation water bath, centrifuge, and supply and reagent stations are placed in a circular pattern around the robotic arm. The reagents, which are particularly labile in this assay, are kept cold in an ice bath. Finished samples are added to scintillation vials by the robotic arm. Because more than one rack of vials is produced in a single uninterrupted robotic procedure, the scintillation vial racks are placed in a tiered holder to allow the robot access to two racks.

A Zymate robot, fitted with exchangeable pipetter hands, has been used to dilute and transfer samples for blood grouping in the blood bank. The robot, configured as a pipetting device, was also used to orient samples for barcode reading. After the robot had performed the liquid handling, a human operator proceeded with additional manual aspects of the test. As discussed earlier, many blood-bank analytical methods are relatively simple and are used in sufficient numbers to warrant a dedicated analyzer.

The most versatile robot available to the clinical laboratory is the articulating robot in that it offers more degrees of freedom than either the Cartesian or the cylindrical robots. The articulating robot has shoulder, elbow, and wrist joints, rotating on a pivoting base. Furthermore, the robot has wrist pitch-and-roll, as well as wrist yaw maneuvers, that allow access to areas often difficult to reach on analytical instruments. Positional accuracy of 0.5 mm or better is obtained by using optically encoded discs that must be set by nesting to a home or zero location each time the robot is turned on. A recent example of a sophisticated articulating robot is from Cyberfluor Inc. (Toronto, Ontario, Canada). The Cyberfluor robot has a high degree of flexibility, with five degrees of freedom. Sample processing is currently the rate-limiting step in most clinical laboratories. Using a robot in conjunction with a clinical centrifuge allows processing of samples as they enter the laboratory. One advantage of an articulating robotic arm is its ability to reach over the rim and into a clinical centrifuge to retrieve samples. For a cylindrical robot to perform this task requires use of a custom-altered centrifuge or a custom-made robotic hand. A novel serial centrifuge has also been developed to separate sera or plasma from formed elements in the blood-collection tube. The single-tube centrifuge will eventually be incorporated into a robotic sample-handling system that should not only speed up laboratory productivity but also reduce risk of exposure to AIDS and hepatitis.

Articulating robots are also beginning to be used in the blood-bank laboratory. One manufacturer of blood-banking automation (Flow Laboratories, McLean, Va.) markets a robot interfaced to various microplate-handling devices (pipetters readers, washers, centrifuges). The entire device (the IROBAL) is enclosed in a protective hood, obviously designed to reduce operator exposure to contaminants.

Establishing control of robot motion to mimic the smooth movement of the human arm with a high degree of repositional precision is a difficult problem addressed by the science of kinematics. Kinematics are applied to the robot in three levels of complexity. First, trajectory planning determines position, velocity, and acceleration for each movement made by the robotic manipulators. Second, inverse kinematics are applied to translate the movements required in the coordinate system into the joint movements required by the particular geometry of the robot being developed. Finally, inverse dynamic equations are applied to establish how the robot moves in response to various applied torques and forces. Each movement of the robot is represented, therefore, by a set of remarkably complex equations, the implementation of which has fortunately been simplified through the use of high-level computer languages.

Robot locomotion is a general term applied to all types of robot movement in which the robot can venture away from a fixed point. Locomotion imparts another degree of freedom to the robot but also allows an increase in the variety of hardware with which a robot can interact. Robots can be made mobile by several methods. Robotic arms can be attached to linear tracks or to a mobile cart. In the case of a mobile cart, the portion of the robot imparts mobility is considered an “Automated Guided or Guidance Vehicle” (AGV). AGVs are either equipped with an automatic onboard guidance system or follow a path on the floor wall or ceiling. Guidance is provided through various sensors, e.g., infrared, video, magnetic, or simple light sensors for reflective tape paths. Equipping AGVs with a robotic component produces a mobile robot. Some robots are being designed to have human-or animal-like gait, so that they may climb stairs, for example. The study of bringing human-or animal-like gait to robotic machines is called bionics.

A recent improvement in robot locomotion is the use of linear tracks. The robotic arms can travel the length of a linear track, either upright or upside down, with positional precision of 0.5 mm. This concept has altered the evolution of laboratory design from circular tables with the fixed robot in the middle, back to the classic laboratory bench stretched along the perimeter of the room. Ergonometric laboratories are now possible, such that either technologists or robots can operate the instruments. Robots that can travel the length of a laboratory bench have performance envelopes (the areas in which the robot can perform useful work) that resemble an elongated hemisphere of a doughnut.

Several attempts at robot locomotion have been tried in the clinical setting. Computer-driven vehicles that move about the hospital corridors picking up specimens and delivering them to the main laboratory have been popularized. Similarly, robotic vehicles that move about the laboratory, returning empty specimen racks to the central specimen-receiving area of the lab have also been designed. Mobile robots that can negotiate the corridors of a hospital for specimen delivery have been investigated by Transitions Research Corp. (TRC, Danbury, Conn.) and Saurer Automation Systems, Inc. (Holland, Mich.). Unlike many mobile robots, the TRC Helpmate does not rely on a guide affixed to the floor. The TRC mobile robot is equipped with infrared, ultrasonic, and vision sensors to acquire information about the environment. With the aid of a preprogrammed knowledge base of the hospital layout, the robot arrives at its destination without colliding with patients or objects in its path. Saurer's AGV follows a fluorescent dye guidepath which may be placed directly onto carpeting.

The mechanical performance of the robot can be enhanced by adding sensor technology on the hands or joints of the robot. Various mechanical and electronic sensor systems may be used, e.g., computerized imaging systems to check for sample integrity and container position for access by a robot. Currently, video systems allow a robot the greatest degree of spatial resolution. Several investigators are looking at the feasibility of tactile sensing in the fingertips of robotic fingers. Tactile sensing approaching that of the human finger is in the foreseeable future.

The advantage of sensor technology is the ability of the robot to respond to changes in the analytical method. With proper sensor technology, closed-loop operation of robots becomes a possibility. Analytical data can be checked by the robot's host computer, which is equipped with an expert system, and corrective measures such as sample re-analysis can be initiated if necessary. Many of these enhancements to increase the intelligence of the robotic system have not been examined in the clinical laboratory setting. However, both the Zymate and Cyberfluor robots have fingers that can sense the presence of absence of objects in their grasp. This feature is helpful if test tubes or syringes are dropped inadvertently during a procedure.

Perhaps the single most important factor that has stimulated the introduction or robotics into the clinical laboratory has been the development of high-level robot programming languages with English language commands. For example, the simple command GOTO MIXER initiates an intricate sequence of steps to drive the robotic arm to the mixing device. Several interfaces away from the user's command, the software generates electronic signals to the robot's motion-control mechanism to coordinate a smooth movement arc that terminates at a precise location near the mixer. Complex algorithms involving robot kinematics translate computer machine-code into signals that control the acceleration after commencing the movement and the deceleration before the robotic arm stops at the mixer. Furthermore, to avoid spilling any liquid, the robotic fingers are held parallel to the work surface throughout the complex series of movements. Elaborate procedures can be developed by combining a series of simple commands, which are programmed and tested individually. The robot can be instructed to pause in a procedure, examine the status of a sensor or instrument, and then proceed through a choice of subsequent programs, depending on the outcome of the test. Programmed intelligence of this sort allows highly adaptive systems for performing many assays.

The integration of the various levels of programing language and the input and output ports of the robotic system are controlled by a high-level robot language. Future robotics software is being directed toward standardization and modularization of the basic operations performed in the clinical laboratory: sample manipulation, liquid handling, separation, conditioning, weighing, measuring, reporting, and storing by use of a modular approach. High-level robotic control languages will reduce the time necessary for assay automation. Intellibotics (Oxnard, Calif.) has used a computer graphics interface to simplify writing robot programs. The programs can be implemented graphically before being used to actually run the robot. Modular programming will allow rapid integration of several basic operation modules into a complete assay procedure with appropriate instrumental status checks. Standardization of interfaces with peripheral hardware (i.e., centrifuge, mixer, and pipetter) will be essential for the rapid incorporation of various sample manipulations in the development of robotically controlled assays.

The term user interface implies a software design that makes many of the complex codes for robotic motion control and data input/output transparent to the user. One should be able to use simple English language commands to train a robot to perform any task within its mechanical performance envelope. Perkin-Elmer Corp., Zymark, and Cyberfluor, Inc. have developed simple-to-use robotic-control languages accessible to most computer programmers. Unfortunately, no robot vendor has simplified all aspects of robotics software. In particular the programing associated with communication with other devices remains incomplete.

The use of digitized images (e.g., a picture of the robot and peripheral equipment on the touch screen computer monitor) should allow the user to point to destinations in the picture to which the robot will then physically move. Graphic image inter-faces should reduce the time needed to train laboratory technologists to implement new procedures. Training a laboratory robot to move to specific coordinates on the robotic work-surface can be effected through either a teaching pendant (a group of switches on a remote control) or directly through the robotic keyboard. The robot is positioned by the trainer to a certain location and then the coordinate is entered into the computer via a switch or press of a key on the keyboard. A second coordinate may then be entered in a similar manner. Using simple commands from the keyboard, one replays the coordinates and the robot will move as instructed. Because robots are inherently blind and without tactile senses, they will collide with any obstacles in the path between the two points. Thus trainers must include a third point in the robot program that will allow a collision-free trajectory. A recent innovation in robotic training is the “limp mode” used by the CRS robot marketed by Cyberfluor. In this mode a robot trainer can simply grasp the robot arm and move it to a location. A press of a button automatically enters the position into the robot software, where it will be repeated once the software routine is started. Some future prospects for robot training may couple hand movements with digitized images of the work surface. The monitor will display a picture of the robotic laboratory from a choice of perspectives (e.g., top or side view). A trainer then moves his or her hands on the computer monitor in the path the robot will take during the execution of a procedure. Imaginative methods to train robots will simplify and accelerate the programming of new procedures. Efficient robotic laboratories use procedures that are reduced to LUOs (laboratory unit operations); these are used repeatedly or recombined in a different order as laboratory procedures change. Creating new procedures is simplified by the modular design of the robotic laboratory. The most basic LUOs encompass the moving of items around the laboratory bench, or manipulation. A subcategory of this LUO is robotic interaction with a matrix. Many designers of robotic software have simplified the steps necessary to define and interact with a matrix, such as a test-tube rack, because retrieving samples is universal to almost all procedures. To be successful, implementation of laboratory robotics requires careful planning, attention to detail, and specialized training of staff and skilled support personnel.

According to the invention there is provided an automated system comprising processing, inspection, and transportation stations for the preparation and delivery of parenteral products to a plurality of stations within a hospital. The system comprises several methods which are currently in the market place. The automated processing of pharmaceutical products via robot devices is not new. Presently employed are robot devices having gripping means presentable to a plurality of stations, each station being adapted to cooperate with the robot device in a sequence of operations such as to produce a measured pharmaceutical dose from a supply of a pharmaceutically acceptable substances, and one of the stations comprising means for locating in parallel a plurality of medical hypodermic syringes for containing a said substance and for operating said syringe. The substance might comprise a medication to be administered to a patient, or a potentially biologically damaging substance, such as a radionuclide or a cytotoxin. The measured dose might be retained in a said syringe, or in a medical vial. Preferably, means are provided for controlling the apparatus in a predetermined sequence of operations.

Sterility is an essential characteristic of injectable and ophthalmic pharmaceutical products. This characteristic is imparted to the product by virtue of the type of manufacturing process. If during the process, all components, solutions and equipment are pre-sterilized and assembled aseptically, that is, using techniques which exclude microorganisms, the product is deemed an “aseptic fill”. Other injectable products, in addition to the aseptic processing, undergo sterilization when in the final container, typically using steam under pressure. This procedure, if properly designed and executed, results in a terminally sterilized product.

One solution to the problems incurred through human contamination is through automation of the processing procedure. A paper entitled, “A Robotics System for the Sterility Testing of Injectables,” Barbara J. Zlotnick and Michael L. Franklin, Pharmaceutical Technology, May 1987, describes a robotics system for sterility testing of vials. According to this paper a robot is used to perform sterility testing and minimize the manipulations performed by the analyst, thereby reducing the potential for technical contamination attributable to personnel. Since human intervention is minimized during testing, the environment of the test remains cleaner with respect to viable particulate matter. There is a lower level of human activity and less potential for contamination from shedding or from disruption of the laminarity of the air flow under the hood. A cleaner environment can then be-used for a greater proportion of the work day.

In general, robotics dispensing devices known in the art include a dispensing apparatus comprising a base, and a robot device on the base. A number of stations are located on the base which cooperate with the robot device in a sequence of operations such as to produce a measured pharmaceutical dose from a supply of pharmaceutically acceptable substances. Robotics dispensing apparatus systems are used for the rapid and efficient processing of a wide variety of pharmaceutical products, as well as perform various mechanical functions. Further, use of the robot device provides an efficient manner in which to maintain a sterile environment to produce the pharmaceutical products.

The transporting of articles via pneumatic tubes is old and well known. Basically, an object is placed within a container which is then transported by air under either positive or negative pressure from one destination to another. The transport is moved within a closed tube. The interior of the closed tube and the outer dimension of the carrier form a seal, so that the carrier can be propelled between the destinations by a vacuum. Pneumatic tube systems known in the art include a closed continuous passageway having a predetermined inner cross-sectional dimension where the passageway includes a plurality of curves or bends having a predetermined radius. A fluid, such as air, is controllably forced through the passageway in a loop to move a carrier through the passageway. In order for the carrier to move freely through the passageway, the dimensions, and in particular the length, of the carriers being used have been limited by the inner cross-sectional dimension and curvature radius of the passageway.

Pneumatic delivery systems are used extensively for the rapid and efficient transportation of a wide variety of articles. These delivery systems are used in a number of business operations, including banks, hospitals, office buildings, industrial plants, and truck terminals as a few examples.

One area of commerce which currently uses the pneumatic tube and the transporting of material via the pneumatic tube on a fairly regular basis is the hospital or biomedical research/manufacturing industry. One particular application of this technology is in the area of transporting blood samples, medicines, intravenous bags, viral samples or other biological or chemical matter between locations within a hospital or laboratory. In that environment, for example, test tubes or vials of liquids are placed within a tube carrier, and are typically secured by foam or clamps within the carrier. The purpose of securing the samples (which are often contained within glass test tubes with rubber stoppers) is to help prevent breakage. When glass breaks or stoppers become dislodged (as can happen when hospital workers fail to properly secure the stoppers in the first place), chemical or biological substances can leak into the interior of the carrier. In turn, said substances can leak out of the interior of the carrier, thereby contaminating the interior walls of the tube system.

The vials or vessels of liquids, solids or gases within the carrier can move or shift during transport, which can also lead to breakage. This problem is especially acute, as the carriers are often traveling at speeds in excess of 25 feet per second. Because of the rapid acceleration and deceleration of pneumatic tube carriers, the carrier contents can easily become dislodged, and can break within the carrier, if not for clamps, foam securing means, and the like. Nonetheless, accidents can happen, whereby despite the best efforts toward securing or protecting the interior vessels, they can break, or their stoppers can become dislodged. In fact, dislodged stoppers are a primary problem, due mainly to workers who may inadvertently fail to secure them properly.

Carriers for use in the present automated pneumatic tube system come in a wide range of sizes and shapes to accommodate the physical articles to be transported in the system. As an example, pneumatic carriers are provided for transporting cash, messages, stock transaction slips, letters, blueprints, electronic data processing cards, x-rays, pharmaceutical supplies, blood samples, narcotics, viral and bacteria cultures, and a variety of other small physical objects.

Various mechanisms have previously been utilized as closure devices for pneumatic tube carriers. For example, many such carriers include an end cap that is hinged with respect to a cylindrical hull on one side of the hull and which has a latch that fastens the end cap to the opposite side of the hull in a closed position. Such carriers employ a variety of fasteners, such as snap fasteners, elastic straps with holes that fit over hooks, or straps that may be secured to bendable posts.

Side opening pneumatic tube carriers are also well-known. One conventional form of such a carrier employs two generally semi-cylindrical sections that are hinged along one longitudinal edge. The hinged sections may be swung toward or away from each other to effectuate opening and closing of the carrier hull. Locking is achieved by virtue of the end caps, which may be twisted to effectuate threaded engagement of the caps onto the carrier hull ends when the hinged hull sections have been closed. That is, the end caps are rotated in such a fashion as to be drawn towards each other onto the ends of the hull, thereby immobilizing the hull sections relative to each other. Rotation of the end caps in the opposite direction releases the hull sections and allows them to be opened.

A particularly preferred configuration comprises a side opening carrier, wherein the two sides are hinged together, and the two sides are held together when the carrier is closed by use of a hook, or detent or indented type locking lip. Such carriers include latching mechanisms to prevent the door from coming ajar or opening during transit, which could cause the carrier to become lodged in the pneumatic tubes and would also allow the contents of the carrier to spill out into the tube system. In addition, the instructions for latching such side opening containers or carriers are simple to follow, so that the container can be easily placed within the tube system. Such hinging and locking mechanisms make waterproofing or sealing the carrier a particularly difficult task, as the hinges and locks are embedded within the mold of the carrier, which is generally formed of plastic.

In another type of side opening pneumatic carrier, the access to the carrier is gained by simultaneously pulling and twisting the ends of the carrier to allow the side opening door to be opened. The instructions for such a two-step process are often difficult for many users to follow, and the physical effort and manual dexterity needed to simultaneously pull and twist both ends of the carrier against a spring resistance is often troublesome for many hospital workers. The pneumatic carrier is preferably easily opened and have a supplemental sensor mechanism to indicate that abnormal interior conditions have developed.

SUMMARY OF THE INVENTION

The present invention relates to a fully automated system for the distribution and retrieval (through an automated pneumatic tube system) of pharmaceutical products to any of a variety of predetermined locations within a hospital, such as nurses' stations. As an alternative, the invention could be made to deliver the parenteral products directly to the patient's room. Specifically, this invention relates to a robotic interface for automatically retrieving products from a pick-up point and placing the products into an open pneumatic tube carrier for delivery to any of a plurality of destinations. A preferred embodiment of this robotic interface (shown in FIG. 13) comprises a gripping means, a dual rod cylinder, a connecting arm, a rotary actuator and a linear thruster, and is preferably located on a base (or table or workstation) being connected thereto by a support means (which can be a support of any known type, such as an aluminum extrusion support).

The system of the present invention will be further described for use with a four-step product preparation and transportation system including the automatic product distribution and receiving stations of the present invention. The four-step process comprises an input queue, a dispensing apparatus comprising a robot device and a plurality of stations from which the robot device works, an inspection station, and a transportation system comprising a pneumatic tube system and automatic distribution and receiving stations. A computer interface provides bi-directional communication between analytical instruments, robots, and peripheral devices and a computer. The robot employed by the system is responsive to computer commands and capable of performing mechanical functions including selection and retrieval of the necessary item (i.e., drug vial, syringe, etc.) and manipulation of retrieved items such that the desired product is prepared. The automatic product distribution station comprising three stages: a barcode application and automatic carrier opening stage; carrier docking stage for product placement into carrier; and a barcode verification, destination confirmation and automatic carrier closing stage. Similarly, the receiving station(s) comprise(s) three stages: an automatic carrier opening stage; carrier docking stage for product removal from carrier; and an automatic carrier closing stage.

The system described will receive its instructions from an interface established between the Parenteral Products Automation System (“PPAS”) described in co-pending Ser. No. 08/513,569 and the Pharmacy Information System present at the facility where the invention is in place. These instructions are communicated to the processing station comprising a robotics device and a plurality of work stations. The robotics device, utilizing weigh stations for quality control, retrieves a drug dosage vial, reconstitutes the powdered drug dosage of the drug, agitates it to effect a complete dissolving of the product in the added diluent, affixes a syringe tip-cap to the diluted product, and labels the final prepared product. The product is transported via a conveyor belt to an inspection station where all of the products are inspected to assure an accurately prepared product. Possible inspection method include manual inspection, gas chromatography, specific gravity testing, and/or barcode scanning. From the inspection station, via conveyor belt, the product enters a staging area for the pneumatic tube system, which determines the appropriate station to send the product based upon information provided on the label affixed to the syringe. There it is automatically loaded into a carrier, which is assigned a discreet identifier, inserted into the appropriate tube, and routed to the correct location. When the carrier is removed from the receiving station the production cycle is ended.

The PPAS control system database is capable of being searched to determine the status of any single parenteral product being prepared. The overall throughput of the system should be approximately 50 units per hour, with no more than 1 hour of downtime required per day for maintenance, supply replenishment, cleaning, etc.

Step one involves the inputs to the PPAS from the transfer of a file which is prepared within the Pharmacy Information System used in the facility being automated. Based on the patient information in the Pharmacy Information System, a computer automatically sends requests to the PPAS for the preparation and delivery of the proper parenteral product to the appropriate location at the time it is to be administered to the patient. These files are commonly used within the Pharmacy Information System to batch production requirements into a grouping of parenteral products required for a precise period of time. This time period can usually be defined by the facility and can be varied to meet its needs. The contents of this file might include the following database elements which may be used by PPAS:

1. Name, strength, and diluent of drug;

2. Name of patient for whom the product is intended;

3. Room number location of patient;

4. Label instructions and notes; and

5. Time the product is due for administration.

Barcodes could be used to provide any of the above mentioned information upon scanning, thus, enabling the control system database to be searched to determine the status of any product at any time during its preparation and transportation. Further, the system could allow for manual requests, input at any of a plurality of computer terminals within the hospital.

Step two of the invention comprises the product preparation which involves a series of manipulations performed by the robotics arm or arms resulting in the preparation of a single intravenous product unit based on the information provided in step one. The robotics arm or arms should be situated such that it can access any of the plurality of stations from which it performs the product preparation. The series of manipulations are as follows:

The drug specified is retrieved by a robotics arm from a gravity feed rack which was hand-fed prior to the initiation of the automated preparation. A sensor should be placed at the end of each column of drug storage to detect an empty rack and thus notify the operation system that the column needs to be replenished. As an alternative, inventory control software could manage the number of units present in the supply rack or column.

Upon retrieval of the correct drug vial by the robotics arm, the protective cap is removed by inserting the vial into a jig and snapping off the protective cap. The exposed rubber stopper of the vial is swabbed on an alcohol impregnated cotton pledget station. The pledget remains moist with isopropyl alcohol due to a wicking action. Prior to start up of the system, the alcohol container must be filled.

After cleaning the stopper with alcohol, the robotics arm is to set the vial down and retrieve from a syringe rack a standard syringe with a needle attached. The arm then removes the protective needle cover by sticking the cap in a jig and pulling straight up. This action exposes the needle, and the protective cap is discarded.

Next the robotics arm moves to another station and inserts the needle into the injection port of a bag of Sterile Water for Injection which is held inverted, and must be changed with every 100 units prepared. The system must notify the operator to change this unit at the appropriate time. For example, inventory control software could keep track of the units prepared. After insertion of the needle, the plunger on the syringe is extracted drawing water into the syringe.

The syringe and needle containing the water is extracted from the Sterile Water for Injection bag. The regular needle is discarded in a Sharps Waste Container at another station and a vented needle is retrieved from a rack and placed on the end of the syringe. The robotics arm returns to the drug vial where it inserts the syringe into the selected vial of drug. The plunger of the syringe is depressed, expelling the Sterile Water for Injection into the drug vial. Once completely emptied, the syringe and vented needle are removed, and the vial and diluent are placed on an agitation table for 60 seconds.

At this point the system should be able to start on the next drug while waiting for the current drug to complete the agitation step. This is important to maintain the productivity of the unit at a high level of output. Also, the agitation table can be divided into four zones, with each zone being designated within the operating system.

Upon completion of agitation, the robotics arm removes the drug vial from its zone of the agitation table and places it upon a compounding counter. The arm then retrieves the appropriate syringe with vented needle, and inserts the needle into the vial of the drug in solution. The complete, attached system of drug vial, syringe and needle is inverted with the syringe pointing upward. The plunger is retracted, thereby withdrawing the entire contents of the drug vial back into the syringe. The syringe and vented needle are removed from the empty drug vial, and the empty vial is placed in a transport bin, which is gravity fed to a staging location adjacent to a conveyor belt.

The robotics arm removes the vented needle from the syringe. This needle is placed in a Sharps Waste Container. The syringe is inverted and a syringe tip cap is placed on its end. The reconstituted drug within the syringe is then labeled by rolling it over the labeling unit.

The syringe containing the reconstituted and labeled drug is then weighed to assure that the unit meets anticipated specifications for weight, assuring that all diluent was added and all of the drug extracted into the syringe. If accepted, the drug is placed in the same transport bin as the empty drug vial, and the transport bin is slid onto the conveyor belt which transporting the product to the inspection station.

In use of the dispenser, (e.g. for obtaining a dose of Technetium 99 m), syringes, needles, needle caps, vials, etc. are stored on racks with sensors to detect empty racks.

If dose dilution is required, saline solution may be withdrawn from an appropriate vial by use of the syringe, and then inserted into a required vial.

It will be understood that if desired the assembly may be modified to accept two, or more syringes, and may be operated in an alternative manner from that described above. For instance, the above described manipulations performed by the robot arm may alternatively be performed individually at each work station while a means is provided to move the product from one station to the next.

Step three represents the manual or automatic inspection procedure incorporated into this invention. It sits midway between the preparation station and the transportation station. In one method, the resultant drug product will be visually inspected for particular matter, proper labeling, and matching of the drug vial to the stated contents on the label. If everything is in order, the product will be initialed by the inspecting pharmacist, and placed back on the conveyor for transportation to the transportation system. The transport bin will be returned to the rack feeding the robotics arm, and the empty drug vial will be discarded.

In an alternate method, the resultant drug product will be automatically inspected. For this, a few alternatives are available: barcode scanning; specific gravity reading; and gas chromatography. Barcode scanning represents an automated method not unlike the manual inspection (i.e., reading and comparing the labels of the vial and product). Reading the specific gravity of the product allows the system to determine the constitution of the product, with which the system can determine whether it is correct or incorrect. Gas chromatography produces similar results as the specific gravity reading through detecting the prior contents of the empty vial and detecting the constitution of the syringe product.

Step four of the present invention relates to a computerized pneumatic tube transport system consisting of distribution and receiving stations, diverters, a blower package and a computer, all connected via single transmission tubing. It is an object of this invention to provide a traditional pneumatic system in conjunction with the automated preparation step to provide a completely automated pharmaceutical preparation and delivery system within a hospital. The conventional pneumatic tube systems are designed to accommodate carriers of conventional design with a length limited by the predetermined curvature radius of the passageways.

The automated pneumatic tube system could be divided into a four zone system with each zone having its own inbound and outbound tubes. Within each zone are a plurality of receiving stations which are all connected via a series of diverters. The diverters also connect the various zones, allowing inter-zone transportation.

The product is transported from the inspection station to the distribution station via conveyor belt or robotic arm. At stage one of the distribution station, the carrier is presented in a closed position where photo eyes verify that the carrier is the appropriate style carrier, that the carrier has an insert, and that the carrier insert is empty. If verified, the carrier is automatically opened. The conveyor then moves the carrier to stage two where the product is inserted into the empty carrier. Next, the carrier is moved to stage three where it is then closed and ready for delivery to the pneumatic tube transport system.

If in stage one the carrier is rejected, the carrier is not opened and is sent to a designated location for inspection, repair, and/or discard. The next carrier is then moved into place in stage one, ready to be checked by the photo eyes. This continues until a useful carrier is detected. Alternatively, the system could notify the control system of the reject status of the carrier. Also, the carriers could be numbered or otherwise labeled to avoid confusion and to simplify correction of problematic carriers.

Once the carrier is ready for delivery (i.e., the product is loaded into the carrier and the carrier closed), the loaded carrier is then sent to into the pneumatic tube transport system where a series of diverters present in the system allow the carrier to be delivered anywhere the system is designed to go. The series of diverters present in the system also allow inter-zone communication, thus allowing the pneumatic tube system to be used for station to station delivery.

Automatic receiving stations according to the present invention also comprise three stages: an automatic carrier opening stage; carrier docking stage for product removal from carrier; and an automatic carrier closing stage. These stations can be used in many applications, for example, automatically receiving lab specimens, automatically removing prepared parenteral products thereby eliminating any problems with sterility, etc.

Additionally, products and/or carriers may be marked in any of a number of ways and identified by any of a number of methods well-known in industry such as barcodes, CCD cameras, magnetic or other markings, etc. In this manner the present system may be maintained in its fully automated state, thereby eliminating the previously discussed problems associated with human interaction.

A carrier for use with the present invention may include two semi-cylindrical mating, elongated members. The two semi-cylindrical members include means for securing the members to each other to provide a closed elongated compartment, each of the members having an outer cross-sectional dimension which is smaller than the inner cross-sectional dimension of the passageway so that the elongated compartment can pass through the curves of the pneumatic system without engaging the inner surface of the passageway, and each of the members further including means for engaging the inner surface of the passageway to accelerate and stabilize the compartment within the passageway, the surface-engaging means having an outer cross-sectional dimension which is generally equal to the predetermined inner cross-sectional dimension of the passageway. A supplemental ring can be installed around the circumference of the carrier (that is, the two semi-cylindrical in their mated, closed position), to provide an enhanced pressure barrier, to help the carrier move throughout the tube system.

The exterior surfaces of the carrier may include one or more accelerator rings formed on the perimeter of both members. The accelerator rings have an outer cross-sectional dimension which allows it to engage the inner surface of the passageway to provide stability to the carrier and allow the carrier to be moved in response to the controlled air pressure within the passageway. Each of the accelerator rings has a small width in relationship to the overall length of the closed elongated compartment, and each is located in proximity to the ends of the first and second members.

The carrier should also be relatively easy to open and be incapable of insertion into the pneumatic tube delivery system in the partially opened condition. The pneumatic carrier will typically be constructed of plastic, and will contain means to secure articles within the carrier during travel. For example, if, as in the present invention, the carrier is used to transport biomedical or chemical materials, many of which could be dangerous, the carrier will contain either, preferably, a series of clips to retain syringes, or alternatively, a formed foam rubber insert, that can be slotted, egg crate shaped, formed with slits or other cavities in any shape or size, including being formed with holes which mate with syringes, circular openings, and so on, so that the materials contained within the carrier are secured to minimize breakage. In addition, the pneumatic carrier is designed to prevent opening of the carrier once it is in transit in the pneumatic tube delivery system. A securing means should be incorporated for that purpose.

Also, the carrier should include means for securing the shells in the closed position. A raised area on the external face of each of the internal closure pieces, and an indented area is formed in the internal face of the external closure pieces, such that the raised and reciprocal indented areas are aligned for engaging one another and securing the shells of the carrier in the closed position. A detent or indented lock or clip is used to secure the two halves of the carrier together.

Alternatively, the carrier could comprise two semi-cylindrical elongated members mated together, an opening at each end of the carrier, and an insert to secure the product in place. The openings allow for insertion of the product into the carrier without requiring removal of the carrier from the carousel.

A sensor (e.g., an electronic computer controlled sensor) may be included within the cavity formed between the two halves of the carrier. That sensor is capable of ascertaining the release of any materials from within the vessel(s) contained within the carrier. For example, the sensor could detect liquids or gasses that should not normally be present within the carrier. In accordance therewith, the sensor can activate a lock or warning light or signal, that alerts the carrier handler that something has been released within the water/air tight carrier, and that special care must be taken before opening the carrier. Alternatively, the control system could direct the defective carrier to a predetermined “safe” location.

While functionally equivalent to conventional steel, aluminum or cardboard carriers in most respects, plastic has the unique characteristic in that it has a certain “memory” for its original shape. That is, if twisted, struck or otherwise subjected to abuse, the plastic of the carrier of the present invention will tend to return to its original shape. In contrast, metal or cardboard carriers, when subjected to heavy use, are frequently permanently bent or distorted, thus detracting from their geometric symmetry and reducing their useful lives. Conventional carriers which are deformed in this way do not maintain a good air seal in the pneumatic line nearly as well as does the present invention. Also, conventional carriers which have been bent or distorted frequently open in the carrier line during use, thus necessitating the closure of the pneumatic tube system as aforesaid.

Numerous criteria are used in designing a carrier for pneumatic systems. It is preferable that the carrier be light, inexpensive and foolproof. Also, the carrier should be arranged so that it cannot be entered into a tube system when in an open position or open while in the tube. Such an arrangement ensures that the carrier is closed before it is entered into the system thereby limiting the possibilities that the carrier contents will be lost in the system and that the carrier will become lodged in the system. The carrier should preferably also be capable of carrying a maximum length of materials around given bends in the system and be capable of being locked in a closed position. A pair of ring seals (referred to also as accelerator, glide or travel rings, etc.) should be provided intermediate the ends of the carrier for guiding the carrier through a pneumatic tube system and for limiting air seepage past the carrier. End portions of the carrier should be tapered to terminate in bumpers and a pair of latches are coupled to the shells for retaining the carrier in a closed position. A lock should be provided for combining with the closed shells to prevent unauthorized opening of the carrier.

Although the present invention as described relates to an automated system for use in hospitals to supply parenteral products, it is not limited to such a use. Other expressions of its use include dietary, laboratory and central supply systems. Also, it may be used in the preparation and transportation of intravenous bags.

Crate Gxt 212 Manual Dexterity 2

It will be appreciated that although the above description is limited to a one directional process (i.e. from product preparation to product delivery to patient), it is obvious that the invention can also operate in the reverse. That is, a prepared product or sample can be sent from any receiving station of the pneumatic tube system back to the hospital pharmacy, or to any other location within the hospital.

BRIEF DESCRIPTION OF THE DRAWINGS

A further understanding of the present invention can be obtained by reference to a preferred embodiment set forth in the illustrations of the accompanying drawing. Although the illustrated embodiment is merely exemplary of systems for carrying out the present invention, both the organization and method of operation of the invention, in general, together with further objectives and advantages thereof, may be more easily understood by reference to the drawings and the following description. The drawing is not intended to limit the scope of this invention, which is set forth with particularity in the claims as appended or as subsequently amended, but merely to clarify and exemplify the invention.

For a more complete understanding of the present invention, reference is now made to the following drawings in which:

FIG. 1 shows an overall functional block diagram of the system of the present invention.

FIG. 2 shows a perspective diagrammatic representation of a selection, reconstitution, and dispensing apparatus.

FIG. 3 shows a perspective diagram of an inspection station.

FIG. 4A shows a perspective diagrammatic representation of an automatic distribution system for injectable products.

FIG. 4B shows a transparent view of the automatic distribution system of FIG. 4A.

FIG. 4C shows an enhanced perspective diagrammatic representation of the auto inspection/closure stage of the automatic distribution system of FIGS. 4A and 4B.

FIG. 5A shows a perspective diagrammatic representation of an automatic distribution system for oral/solid products.

FIG. 5B shows a transparent view of the automatic distribution system of FIG. 5A.

FIG. 5C shows an enhanced perspective diagrammatic representation of the automated oral/solid distributor shown in FIGS. 5A and 5B for an automated pharmacy distribution system.

FIG. 5D shows an enhanced perspective diagrammatic representation of the auto inspection/closure stage of the automatic distribution system of FIGS. 5A and 5B.

FIG. 6 shows an overall view of a carrier suitable for use with the present invention.

FIGS. 6A and 6B shows a cross-section of both the end and side views of a preferable carrier for this invention.

FIG. 7A shows a perspective diagrammatic representation of an automated specimen receiving station.

FIG. 7B shows a transparent view of the automated specimen receiving station of FIG. 7A.

FIG. 7C shows an enhanced perspective diagrammatic representation of the carrier opening stage of the automated specimen receiving station of FIGS. 7A and 7B.

FIG. 8 is a perspective diagrammatic representation of a multi-zone pneumatic tube system.

FIG. 9 shows a diagrammatic representation of a preferred embodiment of the automatic carrier handling system in accordance with the present invention.

FIG. 10 shows a diagrammatic representation of a preferred embodiment of the automatic carrier opening mechanism in accordance with the present invention.

FIG. 11A shows a side view of a diagrammatic representation of an alternate embodiment of the automatic dispatching apparatus (i.e., down-send carrier dispatch) according to the present invention.

FIG. 11B shows a top view of the automatic dispatching apparatus in FIG. 11A.

FIG. 11C shows a side view of an alternate embodiment of the automatic dispatching apparatus (i.e., up-send carrier dispatch) of FIGS. 11A & 11B.

FIG. 12 shows an end view of a down-send dispatch apparatus, demonstrating the automated clamping apparatus for automatically receiving carriers and loading them into a pneumatic tube system.

FIG. 13 shows a perspective diagrammatic representation of a preferred embodiment of an oral/solid robotic interface device according to the present invention for automatically retrieving products from a pick-up point and placing the products into an open pneumatic tube carrier for delivery to any of a plurality of destinations within the system.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

As required, a detailed illustrative embodiment of the present invention is disclosed herein. The present invention relates to a fully automated system for the distribution and retrieval (through an automated pneumatic tube system) of pharmaceutical products to any of a variety of predetermined locations. More specifically, the present invention discloses automatic product distribution and receiving stations. As stated above, the invention will be described in for use with a four-step process for the automatic preparation and transportation of pharmaceutical products comprising an input queue, a dispensing apparatus comprising a robot device and a plurality of stations from which the robot device works, an inspection station, and transportation step. This transportation step includes a pneumatic tube transport system and the automatic distribution and receiving stations of the present invention. Additionally, a computer interface provides bi-directional communication between the computer and analytical instruments, robots, and peripheral devices.

Referring now to FIG. 1, an overview of the present invention is demonstrated in a functional block diagram. It shows input queue step 2 (or task generation step), product preparation step 4, inspection step 6, and automatic distribution and receiving step 8.

Beginning with the product preparation step shown in FIG. 2, the present invention comprises a base 10 having thereon an industrial robot 12 which performs a series of manipulations resulting in the preparation of a single oral/solid or intravenous product unit based upon the information provided by the Pharmacy Information System. The robot 12 may have articulated arms, and gripping means in the form of jaw members having respective depending tangs at a rotatable wrist element of the arm.

Robot 12 may be arranged to present the jaw members at a number of stations including: gravity fed drug rack 14, syringe rack 16, needle supply rack 18, pledget station 40, vial cap removal jig 38, needle cover removal jig 36, needle removal jig 34, diluents rack 28, multi-zone agitation table 30, labeling station 26, weigh station 24, waste outlet 32, and transport bin storage 22.

The drug specified is retrieved by robotics arm 12 from gravity feed rack 14. A sensor located at the end of each column of the drug storage rack will detect an empty rack and notify the operation system that the column needs to be replenished.

With respect to oral/solid drugs, upon retrieval of the correct drug vial by the robotics arm 12, the protective cap is removed at removal jig 38 by inserting the vial into a removal jig 38 and snapping off the protective cap. The robotics arm 12 then brings the vial to another station where the appropriate dosage of oral/solid drug can be determined, for example, at weigh station 24, etc. Such dosage is removed from the vial via the robotic arm and placed into a delivery container. The delivery container is then put in a transport bin selected from transport bin storage 22. The bin with the product is then placed onto conveyor 42 which sends it to the inspection area.

With respect to parenteral products, upon retrieval of the correct drug vial by the robotics arm 12, the protective cap is removed, and the exposed rubber stopper of the vial is swabbed on an alcohol impregnated cotton pledget station 40. The pledget remains moist with isopropyl alcohol due to a wicking action.

After cleaning the stopper with alcohol, robot 12 sets the vial down, retrieves a standard 20 cc syringe with needle attached from syringe rack 16, and removes the protective needle cover by inserting it in needle cover removal jig 36 and pulling straight up. This action exposes the needle, and the protective cap is discarded.

Next, robot 12 inserts the needle into the injection port of a bag of Sterile Water for Injection from diluents rack 28. After insertion of the needle, the plunger on the syringe is extracted to the 20 cc mark, drawing in 20 cc of water into the syringe.

The syringe and needle containing the 20 cc is extracted from the Sterile Water for Injection bag on diluents rack 28. The regular needle is discarded in Sharps Waste Container 32 and a vented needle is retrieved from vented needle rack 18 and placed on the end of the syringe. The syringe is inverted and inserted into the selected vial of drug. The plunger is depressed, expelling the 20 cc of Sterile Water for Injection into the drug vial. The syringe and vented needle are removed, and the vial containing the diluent and drug are placed on agitation table 30 for sixty seconds.

Robot 12 proceeds to start on the next product while waiting for the current drug to complete the agitation step. Agitation table 30 is divided into zones relating to the zones in the automated pneumatic tube system.

Upon completion of agitation, the drug is removed from its zone of agitation table 30 and placed upon a compounding counter. The robot 12 then retrieves the appropriate syringe from syringe rack 16 and vented needle from vented needle rack 18, inserts vented needle into syringe, and inserts the syringe with needle into the vial of the drug in solution. The complete, attached system of drug vial, syringe and needle is inverted, with the drug uppermost and the syringe pointed upward. The plunger is retracted, withdrawing the entire contents of the drug vial back into the syringe. The syringe and vented needle are removed from the empty drug vial, and the empty vial is placed in a transport bin retrieved from transport bin storage 22, which is then fed to a staging location adjacent to conveyor 42.

The vented needle is removed from the syringe while in an upright position. This needle is placed in Sharps Waste Container 32. The syringe is inverted and a syringe tip cap is placed on the end of the syringe. The syringe with the reconstituted drug is labeled by rolling it over labeling station 26.

The labeled syringe with the reconstituted drug is placed on weigh station 24 and weighed to assure that the prepared unit meets anticipated specifications for weight, assuring that all diluent was added, and all drug extracted into the syringe. If accepted, the drug is placed in the same transport bin as the empty drug vial, and the transport bin is slid onto conveyor 42 which transports the product to the inspection station.

Now turning to FIG. 3, the inspection station is shown which can be either manual (i.e., by a highly skilled person) or automatic (i.e., barcode scanning, gas chromatography, and/or specific gravity measuring), where the product is sent after the appropriate drug is prepared, either oral/solid or parenteral. FIG. 3 shows incoming conveyor 42, inspection table 46, and outgoing conveyor 44. The product enters the inspection station via conveyor 42, wherein product is stopped on inspection table 46 to be either manually or automatically inspected. If approved, the product is placed in a transport bin which is placed on conveyor 44 leading to the loading dock of the automatic distribution station.

FIG. 4A shows a preferred embodiment of the automatic accepting, loading, inspecting and distributing station according to the present invention where parenteral or injectable products are automatically loaded into pneumatic tube carrier and sent to their destinations through the pneumatic tube system. As shown, a preferred embodiment for the system of the present invention comprises: blower 52, diverters 54, conventional tubing 56 and AutoAcceptorTube 50. Conveyor 42 transports the products to AutoAcceptorTube 50 according to the present invention and then automatically loads the products into the carrier. Another embodiment may include robot system 43 (sown in FIG. 5A) to load the products into the carrier.

As depicted in FIG. 4A, a preferred embodiment of AutoAcceptorTube 50, the automated system of the invention, comprises carrier opening stage 36, carrier loading stage 38, inspection/closure stage 40 and conveyor 42. The empty carrier first enters opening stage 36, after being transported from an empty carrier storage and distribution system. The carrier is then opened by an automatic opening means in opening stage 36, while at the same time may be manually or automatically inspected for any defects or other problems. Also, the carrier may be barcoded in this stage and labeled with pertinent information, such as time, date, destination, system user, contents, patient, etc. Next, the carrier is moved to loading stage 38 where the appropriate product is automatically placed into the carrier, either via conveyor 42 or robot (not shown).

While the carrier is in opening stage 36, the product is transported to the carrier via incoming conveyor 42 from the product production and inspection stations (shown in FIGS. 2 & 3). In one embodiment, the product enters the carrier through an opening in the top of the system at shown at carrier loading station 38. Once the product is loaded into the carrier, the carrier, along with the product, is moved automatically to the inspection/closing stage 40, the final stage prior to being sent to the pneumatic tube system (see FIG. 4C for an enhanced view of inspection/closing stage 40). Here the product and carrier are inspected, either automatically or manually, and if approved, the carrier is closed securely by an automatic closing mechanism and moved to the pneumatic tube system for delivery to its destination.

Shown in FIG. 4B is a transparent view of the automated distribution system of FIG. 4A, showing its internal structure. Depicted is conventional tubing 56 for a typical pneumatic tube system connected to each end of AutoAcceptorTube 50, which appears as a “box”. Inside AutoAcceptorTube 50 or the “box”, prior to opening stage 36, conventional tubing 56 ends, thereby providing access to the carrier. The carrier is then moved through the three stages via a conveyor-like mechanism inside AutoAcceptorTube 50 where it enters the process described above. At the end of inspection/closing stage 40 conventional tubing 56 begins again, and the closed carrier can be delivered to its destination through the typical pneumatic tube system.

Like FIG. 4A, FIG. 5A shows another embodiment of AutoAcceptorTube 50 for the automatic accepting, loading, inspecting and distributing of oral/solid products to be loaded into a conventional pneumatic tube carrier and sent to their destinations through a conventional pneumatic tube system. Similarly, FIG. 5A shows an automated system comprising carrier opening stage 36, carrier loading stage 38, inspection/closure stage 40 and robot system 43. The empty carrier first enters opening stage 36, after being retrieved from the empty carrier storage and distribution system, and then is automatically opened. The carrier is then moved to loading stage 38 where the appropriate oral/solid product is automatically placed into the carrier by robot system 43. The oral/solid product is brought to the carrier via robot system 43 (an enhancement of robot system 43 is shown in FIG. 5C) which selects the appropriate oral/solid product from product storage station 44. Robot system 43 then inserts the oral/solid product into the carrier through an opening in the top of the system. Once the product is loaded into the carrier, the carrier is moved to the third stage where both the product and carrier are inspected (see FIG. 5D for an enhanced view of inspection/closing stage 40). If approved, the carrier is automatically closed securely by a closing mechanism and sent into the pneumatic tube system where it is delivered to the proper location.

Like FIG. 4B, FIG. 5B shows a transparent view of the automated distribution system of FIG. 5A, showing its internal structure. Depicted is conventional tubing 56 for a typical pneumatic tube system connected to each end of AutoAcceptorTube 50, which appears as a “box”. Inside AutoAcceptorTube 50 or the “box”, prior to opening stage 36, conventional tubing 56 ends, thereby providing access to the carrier. The carrier is then moved through the three stages via a conveyor-like mechanism where it enters the process described above. At the end of inspection/closing stage 40 conventional tubing 56 begins again, and the closed carrier can be delivered to its destination through the typical pneumatic tube system.

A preferred carrier for use with the present invention is shown in FIG. 6. Shown is carrier 60 consisting of first and second shells 62, 62′ which extend longitudinally and which are interconnected by hinges 64 and rod locking members 68. Members 68 lock the rod in place, so that hinges 64 can provide for the opening and closing of the carrier 60 halves 62 and 62′. The carrier 60 halves 62 and 62′ are formed of plastic, for example, and raised areas are formed along the exterior surface, around the transverse perimeter of the carrier, as shown as glide or travel or accelerator rings 66. Two accelerator or glide or travel rings 66 are use for each carrier 60, and may consist of Velcro® secured plastic or rubber strips. A suitable felt material or Neoprene® material may also be used to make the seals 66, which may also be cut from a sheet of the material such that moisture will tend to cause dimension changes substantially in the direction longitudinal with respect to the carrier, rather than radially. The seals 66 may be adhesively attached to the shells 62 and 62′ at respective raised portions. The purpose of the rings 66 is so that carrier 60 forms a tight, consistent and secure fit within the interior of the carrier tubes, so that the carrier 60 may travel effectively through the carrier tubes. As the carriers 60 often reach speeds in excess of 25 feet per second, the rings 66 serve to form an air barrier around the carrier 60, so that the carrier 60 does not jam. Also, by minimizing air leakage around the carrier, rings 66 can minimize the air required to propel carrier 60. Felt insert is provided, as well, so that the rings 66 appear as continuous concentric circles—and no air can escape the seal the rings 66 form in relation to the interior of the carrier tubes, even where the hinge assemblies 64 are concerned. Ends of the carrier are defined by respective resilient bumpers 72. Each of the bumpers 72 is preferably larger than half the diameter of the pneumatic tube to avoid possible jamming of one carrier 60 with a second carrier within the pneumatic tube. The shells 62 and 62′ are substantially identical in shape and are preferably molded in the same or a similar mold form from a suitable plastic material such as LEXAN® (a trade mark for a polycarbonate plastic sold by GE Plastics). Because the shells 62 and 62′ are substantially identical and can often be made from even the same mold, molding costs can be significantly reduced.

In order to simplify this description, parts of shell 62 will be described, but it should be understood that corresponding parts of shell 62′ also may exist, as desired. The shell 62 is generally semi-cylindrical over the major portion of its length, with the exception, for example, of the raised portions under rings 66. Those raised portions may also correspond to internally concaved zones, which may contribute to the overall structural integrity of the carrier 60.

The portions of carrier 60 that support the seals 66 are positioned intermediate the ends of the carrier 60 at positions which maximize the available length and diameter dimensions of the carrier. The shells 62 and 62′ further includes tapered or frusto-conical end portions 70.

Hinge assemblies 64 are preferably molded as a part of the shells 62 and 62′ and the pivot points of the hinges 64 are offset from mating edges of the shells 62 and 62′ to permit the ends of the rings 66 and shells 62 and 62′ to securely mate together when closed, without damage to the seal halves 66. The hinges 64 are preferably located so that they will not contact the interior of the carrier tube walls. Although the carrier tube walls are often made of steel, and the carriers 60 are often made of plastic, it is generally desirable to have only smooth, continuous surfaces contacting the interior of the carrier tube walls. For example, if a metallic hinge 64 were to scratch the interior of the carrier tube wall, ruts could result, which will facilitate air seepage, and a loss of system efficiency, as air passes through said ruts.

Referring now to FIGS. 7A, 7B & 7C, shown is yet another embodiment of the present invention for use an automatic receiving station. FIG. 7A shows AutoAcceptorTube 50 used as an automatic receiving station for receiving products sent in a carrier through a conventional pneumatic tube system. Like FIGS. 4A-B and 5A-B, FIGS. 7A-C show an automated system comprising three stages, carrier opening stage 92, carrier loading stage (here an unloading stage) 94, and carrier closing stage 96. The pneumatic tube carrier containing a product or products first enters opening stage 92 after being transported through the pneumatic tube system. At carrier opening stage 92, the carrier is automatically opened, while also being manually or automatically inspected for any defects or other problems. Via a conveyor-like device, the carrier is moved to carrier unloading stage 94 where the product or products are automatically removed from the carrier by a robot device. Once the product is removed from the carrier, the carrier is moved via the carrier-like device to carrier closing stage 96. Here, the carrier is inspected and automatically closed securely. The empty carrier is then sent back to the empty carrier storage piping (This is disclosed in a co-pending patent application).

Turning next to FIG. 9, shown is yet another alternate embodiment of the automatic carrier loading and distribution apparatus for use in conjunction with a pneumatic tube transport system according to the present invention. In this embodiment, carriers 60′ are introduced to the automatic loading and distributing apparatus from an empty carrier storage piping via clear tubing 100. When a product is ready to be delivered, slidegate 104 opens thereby releasing the next available empty carrier 60′ from clear tubing 100, while pin 102 keeps the remaining empty carriers 60′ in clear tubing 100 from be released as well. When slidegate 104 closes, pin 102 opens thereby releasing empty carriers 60′ such that the next empty carrier 60′ is ready to be released by slidegate 104. Slidegate 104 then opens and the empty carrier 60′ is released into tumbler 106. Tumbler 106 then rotates the carrier and feeds it into load cell 108. Load cell 108 is described in greater detail below in FIG. 10.

Turning next to FIG. 10, shown is carrier 60′ in load cell 108 which comprises rotary actuator 122, drive rolls 132, alignment means 144, drop door 142, and the necessary parts to control these essential elements (they are all described in more detail below). When carrier 60′ is first accepted by load cell 108, it may not be properly aligned for opening by rotary actuator 122. Therefore, carrier 60′ is initially positioned parallel to a pair of drive rolls 132. Drive roll cylinder 130 then moves drive rolls 132 toward carrier 60′ until both drive rolls 132 are adjacent to (i.e., actually touching) carrier 60′. Pivot 136 allows drive rolls 132 to pivot against drive roll cylinder 130, thereby allowing both drive rolls 132 to sit in contact with carrier 60′.

Once, carrier 60′ is situated adjacent to drive rolls 132, drive motor 128 initiates rotation of drive belt 134 which in turn rotates both drive rolls 132. As drive rolls 132 spin, carrier 60′ rotates while remaining in load cell 108. An alignment means 144 (such as photo eyes) detects when carrier 60′ is positioned correctly for opening by rotary actuator 122 (i.e., alignment means 144 may detect when carrier 60′ is positioned with latch hooks 120 in a particular position). As soon as this proper position is detected, instructions are transmitted to the drive motor 128 to stop rotating carrier 60′. However, drive roll cylinder 130 remains in position with drive rolls 132 firmly against carrier 60′ in order to hold carrier 60′ in place while being opened by rotary actuator 122.

A preferred embodiment of latch hook 120 opening means according to the present invention comprises at least the following: slide cylinder 126; double rod cylinder 124 and rotary actuator 122. Once the system detects, via alignment means 144, that latch hooks 120 are properly positioned for opening, the system instructs the opening means to proceed to disengage latch hooks 120. First, slide cylinder 126 moves double rod cylinder 124 and rotary actuator 122 toward latch hooks 120 until rotary actuator 122 contacts latch hooks 120. Second, double rod cylinder 124 initiates the rotation of rotary actuator 122 such that the tip of rotary actuator 122 disengages latch hooks 120 by rotating underneath each latch hook 120 as shown in FIG. 10.

Now that carrier 60′ is in the open position, the product to be transported may be automatically deposited (i.e., via robot, etc.) into carrier 60′. Once the product is loaded, carrier 60′ is automatically closed, barcoded and locked. After completion of the loading in load cell 108, drop door 142 is removed from underneath carrier 60′ by drop cylinder 140. Turning back to FIG. 9, carrier 60′ is then dropped into standing position 116 and moved into position 118 for delivery into the pneumatic tube system. Once carrier 60′ is in position 118 along with the removal of pin 112, blower 52 produces sufficient air flow through air plenum 110 to force carrier 60′ into tubing 100 of the pneumatic tube system. Carrier 60′ containing the loaded product is then on its way to its destination.

Turning next to FIGS. 11A-11C, shown is yet another embodiment of the present invention. FIGS. 11A & 11B show a down-send dispatch embodiment of the automatic dispatching apparatus according to the present invention, while FIG. 11C shows an up-send automatic dispatching apparatus. With both dispatching systems, the empty carrier retrieval unit 166 contains carriers 60 which have been inspected and are ready for loading. First, slidegate 162 opens so that the first carrier 60 drops out of carrier retrieval unit 166 into receiving chute 160. Pin 164 firmly holds the remaining carriers within carrier retrieval unit 166 until slidegate 162 closes, at which point pin 164 opens thereby releasing the next carrier 60 to slidegate 162.

Once carrier 60 reaches the end of receiving chute 160, an operator then manually opens carrier 60, using either the side or top opening mechanism, and manually loads carrier 60 with the product to be delivered. The operator then manually places the loaded carrier 60 onto conveyor 148. The operator may continue loading conveyor 148 until it is full. As conveyor 148 moves, loaded carriers 60 are brought to the automatic down-send dispatch mechanism. While on conveyor 148, carriers 60 are prevented from falling of by side rails 146. Once at the automatic down-send dispatch mechanism, sensors 150 detect the presence of a loaded carrier 60, which then trigger conveyor 148 to stop and trigger clamp 156 to rotate into position to receive carrier 60. When carrier 60 reaches clamp 156, clamp closes around carrier 60 and rotates with carrier 60 to position carrier 60 directly above bell mouth 154 of the pneumatic tubing which leads to the overall pneumatic tube system. Once carrier 60 is released by clamp 156 into bell mouth 154, clamp 156 rotates back to conveyor 148 to receive another carrier 60, and conveyor 148 starts again in order to deliver the next carrier 60 to clamp 156. FIG. 11B merely shows a top view of the down-send dispatch conveyor 148 containing carriers 60 and side rails 146 leading to clamp 156 and bell mouth 154.

Alternatively, an up-send dispatch apparatus as shown in FIG. 11C could be employed. In such an up-send dispatch apparatus, carrier 60 is retrieved, loaded, and brought to the dispatch mechanism in the same manner as described above for the down-send apparatus. However, once carrier 60 on conveyor 148′ reaches the end of conveyor 148′ and is detected by sensors 150′, conveyor 148′ stops and line actuator or air cylinder 152′ receive carrier 60 and force it upward into bell mouth 154′. In the up-send dispatch apparatus, there is no clamp used in transporting carrier 60 from conveyor 148′ to bell mouth 154′ as with the down-send dispatch described above. Again, once carrier 60 is loaded into bell mouth 154′, line actuator or air cylinder 152′ returns to its starting point to receive another carrier 60. Conveyor 148′ starts again which moves the next carrier 60 into line actuator or air cylinder 152′ and the process begins again.

Next, FIG. 12 shows an end view of a down-send dispatch apparatus, demonstrating the automatic clamping apparatus for automatically recieving carriers and loading them into a pneumatic tube system. Carriers 60 are again contained in empty carrier retrieval unit 166 until slidegate 162 opens. When slidegate 162 opens, pin 164 remains in place, holding the remaining carriers 60 inside carrier retrieval unit 166 so that only one carrier is processed at a time. Carrier 60 then drops into open clamp 170 at which point clamp 170 closes and rotates on axis 172 to a position directly above bell mouth 174. Carrier 60 is then released by clamp 170 and dropped into bell mouth 174 for transportation to its destination through a pneumatic tube system. Clamp 170 then returns to its starting position under slidegate 162 where it awaits another carrier 60. This process is then repeated.

Referring next to FIG. 13, shown is a perspective diagrammatic representation of the robotic interface 200 according to the present invention for automatically retrieving products from a pick-up point 202 and placing the products into an open pneumatic tube carrier located in carrier nest 220 for delivery to any of a plurality of destinations. A preferred embodiment of the robotic interface 200 of this invention comprises a gripper 204, a dual rod cylinder 206, a connecting arm 208, a rotary actuator 214 and a linear thruster 212, and is preferably located on a base (or table) (or workstation) 222 being connected thereto by a support means 218 (which can be a support of any known type, such as an aluminum extrusion support).

Preferably, linear thruster 212 is vertically mounted or affixed to support means 218 and comprises multiple expansion and compression cylinders (preferably 2) for vertically thrusting the attached rotary actuator 214. This provides additional flexibility for robotic interface 200 in that in allows for access a plurality of pick-up points 202 which may be stacked vertically. Next, rotary actuator 212, while in compression or expansion with linear thruster 212, is attached on its lower end to connecting arm 208 in a manner which allows for circular movement to at least 180 degrees to permit robotic interface 200 to access, for example, both pick-up point 202 and carrier nest 220 at opposite ends of base 222.

Attached to connecting arm 208 is dual rod cylinder 206 which, like linear thruster 212, comprises multiple expansion and compression cylinders 213 (preferably 2) for horizontally thrusting the attached gripper 204. Again, this provides additional flexibility for robotic interface 200 in that in allows for access to a plurality of pick-up points 202 which may be positioned at various distances from robotic interface 200. Optionally, dual rod cylinder 206 may comprise only a single rod cylinder in order that attached gripper 204 may rotate around the horizontal axis of said single rod cylinder. Once dual rod cylinder 206 is extended such that gripper 204 is able to retrieve the object from pick-up point 202, movable teeth 203 on gripper 204 come together to firmly secure retrieval of the object. Teeth 203 optionally comprise sensors to detect the presence or absence of an object.

Once gripper 204 has retrieved the object from pick-up point 202, a signal is sent to logic controller 210 (which is preferably connected to a computer interface for operation of robotic interface 200) indicating the presence of the retrieved object. Logic controller 210 then instructs robotic interface 200 to transport the object to the open pneumatic tube carrier located in carrier nest 220. This is done by rotary actuator 214 rotating connecting arm 208, dual rod cylinder 206, gripper 204, and the object 180 degrees all together as one unit until the object in teeth 203 of gripper 204 are positioned above the open carrier in carrier nest 220. If necessary, dual rod cylinders 206 will move gripper 204 horizontally until positioned directly above the open carrier in carrier nest 220.

Then, at the point gripper 204 and the object are correctly positioned above the carrier in carrier nest 220, logic controller 210 will instruct teeth 203 to move apart thereby releasing the object into the open carrier. A sensor located in carrier nest 220 is able to detect the presence of the object in the open carrier (e.g., via the change in weight of the carrier now having an object therein, etc.) and transmits a signal logic controller 210 to inform the system that the carrier is ready to be closed and sent to the pneumatic tube transport system for delivery. It is anticipated that the cycle from retrieval of the object to its placement into the carrier will take approximately 8 to 10 seconds, not including other preparation of the object for transportation (i.e., sealing, labeling, etc.).

Optionally, pick-up point 202 could comprise a proximity sensor (not shown) in the area where the object will be waiting to be retrieved by robotic interface 200. It is anticipated that such a sensor would send an electronic signal to logic controller 210 which would, in turn, instruct robotic interface 200 that the object is ready to be retrieved.

The present invention is described above for use with an automated pneumatic tube system. Such an automated pneumatic tube system is shown in FIG. 8. FIG. 8 shows a three-zone system comprising one blower package 84 per zone, pneumatic tubes 88, inter-zone diverters 86, computer 82, and receiving stations 90, all connected via single transmission tubing. Carriers move through the system shown in FIG. 8 under vacuum or pressure as supplied by blower package 84. As the carriers move through the system, the diverters 86 change position to change the direction of the carrier. Also, diverters 86 make inter-zone communications possible.

Although FIG. 8 demonstrates a three zone system with a limited number of receiving stations 90, a system with numerous zones and virtually unlimited stations 90 is possible.

It will be appreciated that although the above description is limited to a system for use in a hospital pharmacy, the invention is applicable for other similar purposes. For instance, the invention may be used with dietaries, laboratories, central supply areas, etc. While the foregoing embodiments of the invention have been set forth in considerable detail for the purposes of making a complete disclosure of the invention, it will be apparent to those skilled in the art that numerous changes may be made in such details without departing from the spirit and the principles of the invention.

Claims (20)

What is claimed is:
1. An apparatus for loading products into a pneumatic tube carrier, said apparatus comprising:
a linear thruster mounted to said support means;
a rotary actuator mounted to the lower end of said linear thruster;
a connecting arm mounted to the lower end of said rotary actuator;
a dual rod cylinder mounted to said connecting arm;
gripping means mounted to said dual rod cylinder; and
a logic controller for controlling and monitoring the loading of said products into said carrier;
wherein said linear thruster controls said rotary actuator;
wherein said rotary actuator controls said connecting arm;
wherein said connecting arm connects said dual rod cylinder to said rotary actuator; and
wherein said dual rod cylinder controls said gripping means.
2. An apparatus according to claim 1, wherein said gripping means further comprise sensors which indicate the presence or absence of said products.
3. An apparatus according to claim 1, wherein said apparatus further comprises an identification means for identifying the intended destination of said carriers.
4. An apparatus according to claim 2, wherein said identification means comprises barcode scanning.
5. An apparatus according to claim 1, wherein said apparatus further comprises an inspecting means for automatically verifying the contents of said carriers.
6. An apparatus according to claim 1, wherein said linear thruster provides vertical movement of said apparatus.
7. An apparatus according to claim 1, wherein said rotary actuator provides rotational movement of said apparatus to at least 180 degrees.
8. An apparatus according to claim 1, wherein said gripping means further comprise at least one pair of teeth.
9. An apparatus for automatically retrieving and loading products into a pneumatic tube carrier for delivery through a pneumatic tube transport system, said apparatus comprising:
a linear thruster;
a dual rod cylinder;
gripping means for retrieving said product; and
a logic controller for controlling and monitoring said apparatus;
wherein said linear thruster is mounted to said support means and controls the vertical movement of said rotary actuator;
wherein said rotary actuator is mounted to the lower end of said linear thruster and controls the rotational movement of said connecting arm;
wherein said connecting arm is mounted to the lower end of said rotary actuator and connects said dual rod cylinder to said rotary actuator; and
wherein said dual rod cylinder is mounted to said connecting arm and controls the lateral movement of said gripping means.
10. An apparatus according to claim 9, wherein said gripping means further comprise sensors which indicate the presence or absence of said products.
11. An apparatus according to claim 9, wherein said apparatus further comprises an identification means for identifying the intended destination of said carriers.
12. An apparatus according to claim 11, wherein said identification means comprises barcode scanning.

Crate Gx 212 Manual Dexterity Activities

13. An apparatus according to claim 9, wherein said apparatus further comprises an inspecting means for automatically verifying the contents of said carriers.
14. An apparatus according to claim 9, wherein said linear thruster provides vertical movement of said apparatus.
15. An apparatus according to claim 9, wherein said rotary actuator provides rotational movement of said apparatus to at least 180 degrees.
16. An apparatus according to claim 9, wherein said gripping means further comprise at least one pair of teeth.
17. An apparatus according to claim 9, wherein said carrier is generally cylindrical and disposed about a longitudinal axis and comprise a hinge means such that said carrier is side opening.
18. A method for automatically retrieving products from a pick-up point and automatically loading said products into a pneumatic tube carrier for delivery to any of a plurality of destinations by means of a pneumatic tube transport system, said method comprising the steps of:
positioning a gripping means at a product distributor;
moving said gripping means to said carrier; and
wherein said gripping means is supported and controlled by a dual rod cylinder which is supported and controlled by a connecting arm which is controlled by and supported at lower end of a rotary actuator which is controlled by and supported at a lower end of a linear thruster which is mounted to a support means; and wherein said positioning, retrieving, moving and loading are controlled by a logic controller.
19. A method according to claim 18, wherein said gripping means comprises movable teeth having sensors thereon for detecting the presence or absence of said product.
20. A method according to claim 18, wherein said method further comprises the step of:
identifying the intended destination of said product by means comprising barcode scanning.
US09/247,2131995-08-101999-02-09Autoacceptertube delivery system with a robotic interface Expired - LifetimeUS6202004B1 (en)

Priority Applications (5)

Crate Amps

Application Number	Priority Date	Filing Date	Title
US63202096Atrue	1996-04-15	1996-04-15
US09/128,592US6173212B1 (en)	1995-08-10	1998-08-03	Autoacceptertube delivery system
US09/247,213US6202004B1 (en)	1995-08-10	1999-02-09	Autoacceptertube delivery system with a robotic interface
US08/935,090Continuation-In-PartUS6048086A (en)	1995-08-10	1997-09-25	Parenteral products automatic system (PPAS) with an oral/solid interface
US09/394,366Continuation-In-PartUS6477442B1 (en)	1995-08-10	1999-09-10	Autoacceptertube delivery system with a robotic interface

Publications (1)

Publication Number	Publication Date
US09/247,213Expired - LifetimeUS6202004B1 (en)	1995-08-10	1999-02-09	Autoacceptertube delivery system with a robotic interface

Country Status (1)

Crate Gxt 212 Manual Dexterity Test

1999

Country	Link
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