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Clinical Neuroanatomy: A Neurobehavioral Approach
John E. Mendoza, Ph.D. Anne L. Foundas, M.D.
Clinical Neuroanatomy: A Neurobehavioral Approach
John E. Mendoza SE Louisiana Veterans Healthcare System New Orleans, LA, USA Tulane Medical School Dept. Psychiatry & Neurology LSU Medical School Dept. of Psychiatry [email protected]
Anne L. Foundas Tulane Medical School Health Sciences Center, Dept. Psychiatry & Neurology New Orleans, LA, USA [email protected]
Library of Congress Control Number: 2007923170
ISBN-13 978-0-387-36600-5
e-ISBN-13 978-0-387-36601-2
Printed on acid-free paper. © 2008 Springer Science+Business Media, Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, Inc, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. 987654321 springer.com
DEDICATION
To the memory of Dr. James C. Young, a brilliant clinician and a good friend. To our students who inspire us to grow, and from whom we often learn as much as we teach.
v
PREFACE
A major focus of clinical neuropsychology and cognitive-behavioral neurology is the assessment and management of cognitive and behavioral changes that result from brain injury or disease. In most instances, the task of the neuropsychologist can be divided into one of two general categories. Perhaps the most common is where patients are known to be suffering from identified neurological insults, such as completed strokes, neoplasms, major head traumas or other disease processes, and the clinician is asked to assess the impact of the resulting brain damage on behavior. The second involves differential diagnosis in cases of questionable insults to the central nervous system. Examples of the latter might be milder forms of head trauma, anoxia and dementia or suspected vascular compromise. In either instance, understanding the underlying pathology and its consequences depends in large part on an analysis of cognitive and behavioral changes, as well as obtaining a good personal and medical history. The clinical investigation will typically include assessing problems or changes in personality, social and environmental adaptations, affect, cognition, perception, as well as sensorimotor skills. Regardless of whether one approaches these questions having prior independent confirmation of the pathology versus only a suspicion of pathology, a fairly comprehensive knowledge of functional neuroanatomy is considered critical to this process. Unfortunately as neuropsychologists we too frequently adopt a corticocentric view of neurological deficits. We recognize changes in personality, memory, or problem solving capacity as suggestive of possible cerebral compromise. We have been trained to think of motor speech problems as being correlated with the left anterior cortices, asymmetries in sensory or motor skills as a likely sign of contralateral hemispheric dysfunction, and visual perceptual deficits as being associated with the posterior lobes of the brain. At the same time there should be an awareness that multiple and diverse behavioral deficits can frequently result from strategically placed focal lesions, and that many such deficits might reflect lesions involving subcortical structures, the cerebellum, brainstem, spinal cord, or even peripheral or cranial nerves. As first noted by Hughlings Jackson in the 19th century, while the cortex is clearly central to all complex human behavior, most cortical activities begin and end with the peripheral nervous system, from sensory input to motor expression. This current work was an outgrowth of seminars given by the principal author (JEM) at the request of neuropsychology interns and residents at the VA to broaden their clinical appreciation and application of functional neuroanatomy. In working closely with neurologists and neurosurgeons, these students also recognized the advantage of being able converse knowledgeably about patients with subtentorial deficits. While all the intricate details of the nervous system may be beyond the immediate needs of most clinicians, a general appreciation of its gross structural makeup and functional relationships is viewed as essential in working with neurological populations. To this end, the book begins with a brief review of the gross anatomy, functional correlates, and behavioral syndromes of the spinal cord and peripheral nervous system. From there, the text carries one rostrally, looking at these same features in the cerebellum, brainstem and cranial nerves. Where this volume deviates from most textbooks of functional neuroanatomy is in its expanded treatment of supratentorial structures, particularly the cerebral cortex itself, which more directly impacts on those aspects of behavior and cognition that often represent the primary focus or interests of neuropsychologists and behavioral neurologists. vii
viii
Preface
The final chapters are devoted to the vascular supply and neurochemical substrates of the brain and their clinical and pathological ramifications. In addition to simply reviewing structural neuroanatomy and providing the classically defined behavioral correlates of the major divisions of the CNS, a major focus of this work will be to attempt to integrate functional systems and provide the reader with at least a tentative conceptual model of brain organization and how this organization is important in the understanding of behavioral syndromes. For the neuropsychologist, of equal importance to an understanding of clinical neuroanatomy is an appreciation of neuropathology, i.e., the natural history, associated signs and symptoms and physiological and/or neurological correlates underlying specific disease states. While occasional references are made to these factors throughout the text, an adequate treatment of this subject is beyond the scope of this book and the reader is advised to supplement this information with other works that specifically address these latter topics. In going through the chapters the reader will notice some redundancy. This was purely intentional as a means of reinforcing certain key concepts and promoting their retention. Care was taken to try and resolve any discrepancies with regard to either structural or functional issues that appeared to be in dispute. However, our collective knowledge of the nervous system is still very incomplete and is often derived as much from clinical impressions and correlations as it is from definitive experimental paradigms. This is particularly true as we progress from peripheral pathways to central mechanisms in the brain. Part of the problem is the complexity of the nervous system itself and the technical (and ethical) limitations of carefully controlled studies, especially in man. Another problem is simply the startling limitations of our own knowledge. We are still far from being able to create a good working model of the brain. Thus, as we progress along the neural axis from the spinal cord to the brain, much of the data presented will be increasingly speculative. However, it is hoped that the sum total of this exercise will provide the reader not only with a broad overview of functional neuroanatomy, but will provide a beginning framework for trying to conceptualize brain-behavior relationships and the effects of focal lesions on behavior. Although this book was initially written for neuropsychologists, it provides a practical review of this subject for clinicians in other disciplines who work with the neurologically impaired, particularly neurologists and behavioral neurologists. Finally, a number of acknowledgements are in order. Throughout the text, it will be noted that a large number of the figures use photographs of the brain and other neural structures derived from the Interactive Brain Atlas (1994). These base images were provided courtesy of the University of Washington and proved invaluable in illustrating anatomical landmarks. Two additional points should be made in this regard. First, the labeling of these images was done by one of the authors (JEM), thus any errors that might be found are not the responsibility of the University of Washington. Second, while the monochrome images used here were preferred for our text, the University of Washington has an updated version of this interactive atlas, which is highly recommended for anyone interested in an easy and entertaining way to review basic neuroanatomy. Thanks are also in order to the University of Illinois Press, Western Psychological Services, and Dr. Kenneth Heilman for permission to use published materials, as well as to Dr. Jose Suros who provided several brain images and to Dr. Enrique Palacios who was kind enough to review the radiographic images. It also seems appropriate to mention Stephen Stahl whose works on psychopharmacology provided inspiration for much of the material contained in Chapter 11. A special acknowledgment is reserved for Mr. Eugene New, a medical illustrator from the LSU Health Sciences Center, who is responsible for all the artwork seen throughout the text.
CONTENTS
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii 1.
The Spinal Cord and Descending Tracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1
2.
The Somatosensory Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
23
3.
The Cerebellum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
4.
The Brainstem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5.
The Cranial Nerves . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
6.
The Basal Ganglia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
7.
The Thalamus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
8.
The Limbic System/Hypothalamus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 213
9.
The Cerebral Cortex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
77
10. The Cerebral Vascular System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 501 11. Neurochemical Transmission . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 545 Appendix . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 643 Glossary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 657 Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 689
ix
John E. Mendoza, Ph.D. Anne L. Foundas, M.D.
Clinical Neuroanatomy: A Neurobehavioral Approach
John E. Mendoza SE Louisiana Veterans Healthcare System New Orleans, LA, USA Tulane Medical School Dept. Psychiatry & Neurology LSU Medical School Dept. of Psychiatry [email protected]
Anne L. Foundas Tulane Medical School Health Sciences Center, Dept. Psychiatry & Neurology New Orleans, LA, USA [email protected]
Library of Congress Control Number: 2007923170
ISBN-13 978-0-387-36600-5
e-ISBN-13 978-0-387-36601-2
Printed on acid-free paper. © 2008 Springer Science+Business Media, Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, Inc, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. 987654321 springer.com
DEDICATION
To the memory of Dr. James C. Young, a brilliant clinician and a good friend. To our students who inspire us to grow, and from whom we often learn as much as we teach.
v
PREFACE
A major focus of clinical neuropsychology and cognitive-behavioral neurology is the assessment and management of cognitive and behavioral changes that result from brain injury or disease. In most instances, the task of the neuropsychologist can be divided into one of two general categories. Perhaps the most common is where patients are known to be suffering from identified neurological insults, such as completed strokes, neoplasms, major head traumas or other disease processes, and the clinician is asked to assess the impact of the resulting brain damage on behavior. The second involves differential diagnosis in cases of questionable insults to the central nervous system. Examples of the latter might be milder forms of head trauma, anoxia and dementia or suspected vascular compromise. In either instance, understanding the underlying pathology and its consequences depends in large part on an analysis of cognitive and behavioral changes, as well as obtaining a good personal and medical history. The clinical investigation will typically include assessing problems or changes in personality, social and environmental adaptations, affect, cognition, perception, as well as sensorimotor skills. Regardless of whether one approaches these questions having prior independent confirmation of the pathology versus only a suspicion of pathology, a fairly comprehensive knowledge of functional neuroanatomy is considered critical to this process. Unfortunately as neuropsychologists we too frequently adopt a corticocentric view of neurological deficits. We recognize changes in personality, memory, or problem solving capacity as suggestive of possible cerebral compromise. We have been trained to think of motor speech problems as being correlated with the left anterior cortices, asymmetries in sensory or motor skills as a likely sign of contralateral hemispheric dysfunction, and visual perceptual deficits as being associated with the posterior lobes of the brain. At the same time there should be an awareness that multiple and diverse behavioral deficits can frequently result from strategically placed focal lesions, and that many such deficits might reflect lesions involving subcortical structures, the cerebellum, brainstem, spinal cord, or even peripheral or cranial nerves. As first noted by Hughlings Jackson in the 19th century, while the cortex is clearly central to all complex human behavior, most cortical activities begin and end with the peripheral nervous system, from sensory input to motor expression. This current work was an outgrowth of seminars given by the principal author (JEM) at the request of neuropsychology interns and residents at the VA to broaden their clinical appreciation and application of functional neuroanatomy. In working closely with neurologists and neurosurgeons, these students also recognized the advantage of being able converse knowledgeably about patients with subtentorial deficits. While all the intricate details of the nervous system may be beyond the immediate needs of most clinicians, a general appreciation of its gross structural makeup and functional relationships is viewed as essential in working with neurological populations. To this end, the book begins with a brief review of the gross anatomy, functional correlates, and behavioral syndromes of the spinal cord and peripheral nervous system. From there, the text carries one rostrally, looking at these same features in the cerebellum, brainstem and cranial nerves. Where this volume deviates from most textbooks of functional neuroanatomy is in its expanded treatment of supratentorial structures, particularly the cerebral cortex itself, which more directly impacts on those aspects of behavior and cognition that often represent the primary focus or interests of neuropsychologists and behavioral neurologists. vii
viii
Preface
The final chapters are devoted to the vascular supply and neurochemical substrates of the brain and their clinical and pathological ramifications. In addition to simply reviewing structural neuroanatomy and providing the classically defined behavioral correlates of the major divisions of the CNS, a major focus of this work will be to attempt to integrate functional systems and provide the reader with at least a tentative conceptual model of brain organization and how this organization is important in the understanding of behavioral syndromes. For the neuropsychologist, of equal importance to an understanding of clinical neuroanatomy is an appreciation of neuropathology, i.e., the natural history, associated signs and symptoms and physiological and/or neurological correlates underlying specific disease states. While occasional references are made to these factors throughout the text, an adequate treatment of this subject is beyond the scope of this book and the reader is advised to supplement this information with other works that specifically address these latter topics. In going through the chapters the reader will notice some redundancy. This was purely intentional as a means of reinforcing certain key concepts and promoting their retention. Care was taken to try and resolve any discrepancies with regard to either structural or functional issues that appeared to be in dispute. However, our collective knowledge of the nervous system is still very incomplete and is often derived as much from clinical impressions and correlations as it is from definitive experimental paradigms. This is particularly true as we progress from peripheral pathways to central mechanisms in the brain. Part of the problem is the complexity of the nervous system itself and the technical (and ethical) limitations of carefully controlled studies, especially in man. Another problem is simply the startling limitations of our own knowledge. We are still far from being able to create a good working model of the brain. Thus, as we progress along the neural axis from the spinal cord to the brain, much of the data presented will be increasingly speculative. However, it is hoped that the sum total of this exercise will provide the reader not only with a broad overview of functional neuroanatomy, but will provide a beginning framework for trying to conceptualize brain-behavior relationships and the effects of focal lesions on behavior. Although this book was initially written for neuropsychologists, it provides a practical review of this subject for clinicians in other disciplines who work with the neurologically impaired, particularly neurologists and behavioral neurologists. Finally, a number of acknowledgements are in order. Throughout the text, it will be noted that a large number of the figures use photographs of the brain and other neural structures derived from the Interactive Brain Atlas (1994). These base images were provided courtesy of the University of Washington and proved invaluable in illustrating anatomical landmarks. Two additional points should be made in this regard. First, the labeling of these images was done by one of the authors (JEM), thus any errors that might be found are not the responsibility of the University of Washington. Second, while the monochrome images used here were preferred for our text, the University of Washington has an updated version of this interactive atlas, which is highly recommended for anyone interested in an easy and entertaining way to review basic neuroanatomy. Thanks are also in order to the University of Illinois Press, Western Psychological Services, and Dr. Kenneth Heilman for permission to use published materials, as well as to Dr. Jose Suros who provided several brain images and to Dr. Enrique Palacios who was kind enough to review the radiographic images. It also seems appropriate to mention Stephen Stahl whose works on psychopharmacology provided inspiration for much of the material contained in Chapter 11. A special acknowledgment is reserved for Mr. Eugene New, a medical illustrator from the LSU Health Sciences Center, who is responsible for all the artwork seen throughout the text.
CONTENTS
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii 1.
The Spinal Cord and Descending Tracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1
2.
The Somatosensory Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
23
3.
The Cerebellum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
4.
The Brainstem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5.
The Cranial Nerves . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
6.
The Basal Ganglia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
7.
The Thalamus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
8.
The Limbic System/Hypothalamus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 213
9.
The Cerebral Cortex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
77
10. The Cerebral Vascular System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 501 11. Neurochemical Transmission . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 545 Appendix . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 643 Glossary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 657 Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 689
ix
Neuroanatomy Pdf
<ul><li><p>Neurophysiology and Neuroanatomy 1452. ALTHER, E. (1970) Tissue reactions to ventriculocardial drainage of the cerebrospinal </p><p>fluid following the implantation of drainage systems. (German.) Mschr. Kinderheilk, 118, 585-591, </p><p>1453. ANCRI, D. (1971) Cerebral scintigraphy. (French.) Rev. Prat. (Paris), 12, 21 19-2135. 1454. ATANASSOV, K., LUNGWITZ, J. (1971) Relations between asymmetry of the basal EEG </p><p>activity and pneumoencephalographic findings in children. (German.) Psychiat. Neurol. med. Psychol., 23, 87-93. </p><p>1455. ATKINSON, W. J. (1971) Studies in the movement of isotopes R P S A and NaZ4 from ventricular CSF fluid. Develop. Med. Child Neurol., 13, 51-62. </p><p>1456. BARNET, A. B. (1971) Evoked potentials in handicapped children. Develop. Med. Child Neurol., 13, 3 13-320. </p><p>1457. BASS, N. H., NETSKY, M. G., YOUNG, E. (1970) Effects of malnutrition on developing cerebrum. I. Microchemical and histologic study of cellular differentiation in the rat. Arch. Neurol. (Chic.), 23, 289-302. </p><p>1458. BASS, N. H., NETSKY, M. G., YOUNG, E. (1970) Effects of malnutrition on developing cerebrum. 11. Microchemical and histologic study of myelin formation in the rat. Arch. Neurol. (Chic.), 23, 303-3 13. </p><p>1459. BENTSON, J. R., WILSON, G. H. (1971) Cerebral angiography: normal anatomy and variations in adults and children. Semin. Roentgenol., 6, 17-33. </p><p>1460. BILLEWICZ, O., BABIN, E. (1970) Pneumographic study of the fourth ventricle in children. Neuroradiology, 1, 220-222. </p><p>1461. BLAIR, A. W. (1971) Sensory examination using electrically induced somatosensory potentials. Develop. Med. Child Neurol., 13, 447-455. </p><p>1462. BRADAC, G. B., SIMONS, R. S . (1971) Pneumoencephalographic studies of the development of the brain stem and skull base in childhood. Neuroradiology, 2, 11 1-1 14. </p><p>1463. BUCHBERGER, J., NOVOZAMSKY, V. (1971) Motor excitability in trained and untrained children. Europ. Neurol., 5, 7-10. </p><p>1464. CHASE, H. P., DABIERE, C . S . , WELCH, N. N., OBRIEN, D. (1971) Intrauterine under- nutrition and brain development. Pediatrics, 47, 49 1-500. </p><p>1465. DAVSON, H., HOLLINGSWORTH, G., SEGAL, M. B. (1970) The mechanism of drainage of the cerebrospinal fluid. Brain, 93, 665-678. </p><p>1466. DERBY, B. M. (1970) The structural basis of the minims1 cerebral dysfunction syndrome. Electroenceph. clin. Neurophysiol., 29,4 12. (Summary.) </p><p>1467. DILL, R. (1 971) Normal echo-encephalographic values of the cerebral ventricular system and their development during childhood. (German.) Mschr. Kinderheilk., 119, </p><p>1468. DOBBING, J. (1970) Undernutrition and the developing brain. The relevance of animal </p><p>1469. DOBBING, J. (1970) The kinetics of growth. Lancet, ii, 1358. (Letter.) </p><p>496-502. </p><p>models to the human problem. Amer. J . Dis. 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